ChemInform Abstract: SELECTIVE MONO-ALKYLATION AND ARYLATION OF AROMATIC DIHALIDES BY PALLADIUM-CATALYZED CROSS-COUPLING WITH THE GRIGNARD AND ORGANOZINC REAGENTS

1980 ◽  
Vol 11 (23) ◽  
Author(s):  
A. MINATO ◽  
K. TAMAO ◽  
T. HAYASHI ◽  
K. SUZUKI ◽  
M. KUMADA
Keyword(s):  
Cross Coupling ◽  
Palladium Catalyzed ◽  
Organozinc Reagents

Pd-Catalyzed Cross-Coupling Reaction of Sterically Hindered Vinyl Iodides and Organozinc Reagents. Synthesis of Vitamin D Analogues with an Aromatic Ring Attached at C-17

2002 ◽  
Vol 67 (11) ◽  
pp. 1658-1668 ◽  
Author(s):  
Agnieszka Przezdziecka ◽  
Alicja Kurek-Tyrlik ◽  
Jerzy Wicha
Keyword(s):  
Vitamin D ◽  
Butyl Ester ◽  
Acid Methyl Ester ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Building Blocks ◽  
Vitamin D Analogues ◽  
Aryl Bromides ◽  
Palladium Catalyzed ◽  
Organozinc Reagents

Palladium-catalyzed coupling of steroid 17-iodo-6β-methoxy-3α,5-cyclo-5α-androst-16-ene (4) 17-iodoandrosta-5,16-dien-3β-ol (5), and structurally similar (3aS,7R,7aR)-benzenesulfonyl-3-iodo-3a-methyl-3a,4,5,6,7,7a-hexahydro-1H-indene (6) with various arylzinc chlorides, which were generated from aryl bromides 8 [1-bromomethylbenzene (8a), O-(triethylsilyl-2-bromophenyl)propan-2-ol (8b), 2-(4-bromophenyl)propan-2-ol (8c), 4-bromobenzonitrile (8d), 4-bromobenzoic acid methyl ester (8e), 4-bromobenzoic acid tert-butyl ester (8f) and 3-bromopyridine (8g)] via aryllihium derivatives (the Negishi coupling) was examined. The respective cross-coupling products were obtained in good yields for all aryl bromides except of 8c and 8e. Building blocks for synthesis of certain vitamin D analogues have been prepared.

A Novel Palladium-Catalyzed Cross-Coupling of Thiomethylated Alkynes with Functionalized Organozinc Reagents

Synthesis ◽  
2010 ◽  
Vol 2010 (12) ◽  
pp. 2085-2091 ◽  
Author(s):  
Paul Knochel ◽  
Laurin Melzig ◽  
Jérémy Stemper
Keyword(s):  
Cross Coupling ◽  
Palladium Catalyzed ◽  
Organozinc Reagents

Selective mono-alkylation and arylation of aromatic dihalides by palladium-catalyzed cross-coupling with the Grignard and organozinc reagents

1980 ◽  
Vol 21 (9) ◽  
pp. 845-848 ◽  
Author(s):  
Akio Minato ◽  
Kohei Tamao ◽  
Tamio Hayashi ◽  
Keizo Suzuki ◽  
Makoto Kumada
Keyword(s):  
Cross Coupling ◽  
Palladium Catalyzed ◽  
Organozinc Reagents
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