ChemInform Abstract: SELF-SENSITIZED PHOTOOXIDATION OF PROTOPORPHYRIN IX AND RELATED FREE-BASE PORPHYRINS IN NATURAL AND MODEL MEMBRANE SYSTEMS. EVIDENCE FOR NOVEL PHOTOOXIDATION PATHWAYS INVOLVING AMINO ACIDS

1984 ◽  
Vol 15 (31) ◽  
Author(s):  
M. KRIEG ◽  
D. G. WHITTEN
Keyword(s):  
Amino Acids ◽  
Protoporphyrin Ix ◽  
Model Membrane ◽  
Free Base ◽  
Membrane Systems

How does Amphotericin B Work?: Studies on Model Membrane Systems

1993 ◽  
Vol 3 (3) ◽  
pp. 377-408 ◽  
Author(s):  
Scott C. Hartsel ◽  
Christopher Hatch ◽  
Woubeshet Ayenew
Keyword(s):  
Amphotericin B ◽  
Model Membrane ◽  
Membrane Systems

Transition Metal‐Free, Base‐Induced Arylation of Amino Acids: Synthesis of N ‐( para ‐Substituted phenyl)amino‐2‐carboxylic acids

2020 ◽  
Vol 5 (28) ◽  
pp. 8644-8648 ◽  
Author(s):  
Adejoke D. Osinubi ◽  
Josephat U. Izunobi ◽  
Olayinka T. Asekun ◽  
Oluwole B. Familoni ◽  
Xiaoguang Bao
Keyword(s):  
Amino Acids ◽  
Transition Metal ◽  
Carboxylic Acids ◽  
Free Base ◽  
Metal Free

scholarly journals Determination of the structure of an N-substituted protoporphyrin isolated from the livers of griseofulvin-fed mice

1995 ◽  
Vol 307 (2) ◽  
pp. 505-512 ◽  
Author(s):  
R M A Bellingham ◽  
A H Gibbs ◽  
F de Matteis ◽  
L Y Lian ◽  
G C K Roberts
Keyword(s):  
Zinc Complex ◽  
Pyrrole Ring ◽  
Protoporphyrin Ix ◽  
Free Base ◽  
Mechanism Of Formation ◽  
Ring Nitrogen ◽  
Green Pigments ◽  
Anti Fungal ◽  
Pyrrole Nitrogen

Feeding mice with griseofulvin, a widely used anti-fungal agent which induces protoporphyria as a side-effect, leads to the formation in the liver of two green pigments which have been shown to be porphyrin adducts. In this work, the major porphyrin adduct isolated from the livers of griseofulvin-fed mice has been characterized structurally using one- and two-dimensional NMR spectroscopy. The adduct was shown to be an N-alkylated protoporphyrin IX in which the whole of griseofulvin (less a hydrogen atom) is attached to a pyrrole ring nitrogen of the porphyrin. It was shown that the drug-to-porphyrin linkage is an an -O-CH2-Npyrrole = linkage, to either the 4- or 6-position of ring a of griseofulvin. In an attempt to identify which pyrrole nitrogen is involved in this linkage, the 1H spectra of the free base and zinc complex of the adduct were compared with the corresponding spectra of the four regioisomers of N-methylprotoporphyrin. These comparisons indicated that the adduct isolated from the livers of griseofulvin-fed mice is either the NC or the ND regioisomer, although a clear distinction between these two could not be made on the available evidence. The mechanism of formation of the adduct and its relation to griseofulvin-induced protoporphyria are discussed.

scholarly journals Iron Mediated Interaction of Alpha Synuclein with Lipid Rafts in Model Membrane Systems

2018 ◽  
Vol 114 (3) ◽  
pp. 244a
Author(s):  
Loredana Casalis ◽  
Fabio Perissinotto ◽  
Denis Scaini
Keyword(s):  
Lipid Rafts ◽  
Alpha Synuclein ◽  
Model Membrane ◽  
Membrane Systems
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