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Wound healing is a process which starts with inflammatory response after damage occurrence. This process
happens by restoring the wound surface coating tissue, migrating fibroblasts to form the needed collagen, forming a
healing tissue and finally contortion and extraction of the wound. Today, various drugs are used to heal the wound.
However, the used drugs to repair wounds have some defects and side effects. In spite of all attempts to accelerate wound
healing definitely, no safe drug has been introduced for this purpose. Therefore, the necessity of identifying herbal plants
in ethnopharmacology and ethnobotany documents with healing effect is felt essential. In this article we tried to review
and present Iranian effective medicinal plants and herbal compounds used for wound healing. Searching was performed
on databases including ISI Web of Science, PubMed, PubMed Central, Scopus, ISC, SID, Magiran and some other
databases. The keywords used included wound healing, skin treatment, medicinal plants, ethnobotany, and phytotherapy.
In this regard, 139 effective medicinal plants on wound healing were identified based on ethnopharmacology and
ethnobotanical sources of Iran. Medicinal plants such as Salvia officinalis, Echium amoenum, Verbascum spp.,
G1ycyrrhiza glabra, Medicago sativa, Mentha pulegium, Datura stramonium L., Alhagi spp., Aloe vera, Hypericum
perforatum, Pistacia atlantica and Prosopis cineraria were the most important and effective medicinal plants on wound
healing in Iran. These native Iranian medicinal plants are full of antioxidants and biological compounds and might be used
for wound healing and preparation of new drugs.
