ChemInform Abstract: C32-O-Imidazol-2-yl-methyl Ether Derivatives of the Immunosuppressant Ascomycin with Improved Therapeutic Potential.

ChemInform ◽  
2010 ◽  
Vol 29 (51) ◽  
pp. no-no
Author(s):  
M. T. GOULET ◽  
ET AL. ET AL.
Keyword(s):  
Methyl Ether ◽  
Therapeutic Potential ◽  
Derivatives Of

C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential

1998 ◽  
Vol 8 (16) ◽  
pp. 2253-2258 ◽  
Author(s):  
Mark T. Goulet ◽  
Shelli R. McAlpine ◽  
Mary Jo Staruch ◽  
Samuel Koprak ◽  
Francis J. Dumont ◽  
...  
Keyword(s):  
Methyl Ether ◽  
Therapeutic Potential ◽  
Derivatives Of

scholarly journals Therapeutic potential of pregnenolone and pregnenolone methyl ether on depressive and CDKL5 deficiency disorders: focus on microtubule targeting

2021 ◽  
Author(s):  
Isabella Barbiero ◽  
Massimiliano Bianchi ◽  
Charlotte Kilstrup‐Nielsen
Keyword(s):  
Methyl Ether ◽  
Therapeutic Potential

Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters [Bioorg. Med. Chem. Lett. 13 (2003) 2933]

2003 ◽  
Vol 13 (23) ◽  
pp. 4163 ◽  
Author(s):  
Casey C McComas ◽  
Brendan M Crowley ◽  
Inkyu Hwang ◽  
Dale L Boger
Keyword(s):  
Methyl Ether ◽  
Methyl Esters ◽  
Derivatives Of

scholarly journals Screening of Chloroquine, Hydroxychloroquine and Its Derivatives for Their Binding Affinity to Multiple SARS-CoV-2 Protein Drug Targets

2020 ◽  
Author(s):  
Mallikarjuna Nimgampalle ◽  
Vasudharani Devanthan ◽  
Ambrish Saxena
Keyword(s):  
Binding Affinity ◽  
In Silico ◽  
Drug Targets ◽  
Therapeutic Potential ◽  
Viral Proteins ◽  
Protein Drug ◽  
Potential Treatment ◽  
Health Authorities ◽  
Derivatives Of

Recently Chloroquine and its derivative Hydroxychloroquine have garnered enormous interest amongst the clinicians and health authorities’ world over as a potential treatment to contain COVID-19 pandemic. The present research aims at investigating the therapeutic potential of Chloroquine and its potent derivative Hydroxychloroquine against SARS-CoV-2 viral proteins. At the same time we have screened some chemically synthesized derivatives of Chloroquine and compared their binding efficacy with chemically synthesized Chloroquine derivatives through <i>in silico</i>approaches. For the purpose of the study, we have selected some essential viral proteins and enzymes implicated in SARS-CoV-2 replication and multiplication as putative drug targets.<br>

Synthesis of methyl ether derivatives of sucrose

1975 ◽  
Vol 43 (2) ◽  
pp. 360-365 ◽  
Author(s):  
Michael G. Lindley ◽  
Gordon G. Birch ◽  
Riaz Khan
Keyword(s):  
Methyl Ether ◽  
Derivatives Of

scholarly journals Pharmacological Advances of Chloroquine and Hydroxychloroquine: From Antimalarials to Investigative Therapies in COVID-19

2020 ◽  
Vol 15 (9) ◽  
pp. 1934578X2095364
Author(s):  
Yang Song ◽  
Elise Fields
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Adverse Effects ◽  
Viral Infection ◽  
Therapeutic Potential ◽  
Pharmacological Activities ◽  
Pharmaceutical Applications ◽  
Natural Alkaloid ◽  
Derivatives Of ◽  
Existing Chemicals

During the coronavirus disease 2019 (COVID-19) pandemic, numerous existing chemicals have been screened for antiviral potential against the emerging coronavirus severe acute respiratory syndrome coronavirus 2. Chloroquine and hydroxychloroquine, after exhibiting potent in vitro efficacy, have gained tremendous attention. Both therapeutics are derivatives of natural alkaloid quinine and were first synthesized to treat malaria. Thereafter, the pharmaceutical applications of the agents have expanded to many new areas. In this article, the medicinal history and pharmacological activities of chloroquine and hydroxychloroquine are summarized. Antimalarial, anti-inflammatory, antitumor, antiviral properties, and therapeutic potential in the emerging viral infection COVID-19 are discussed. Pharmacokinetics, adverse effects, and toxicities are reviewed.

Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters

2003 ◽  
Vol 13 (17) ◽  
pp. 2933-2936 ◽  
Author(s):  
Casey C. McComas ◽  
Brendan M. Crowley ◽  
Inkyu Hwang ◽  
Dale L. Boger
Keyword(s):  
Methyl Ether ◽  
Methyl Esters ◽  
Derivatives Of

scholarly journals Synthesis and Evaluation of Selected Key Methyl Ether Derivatives of Vancomycin Aglycon

2010 ◽  
Vol 53 (19) ◽  
pp. 7229-7235 ◽  
Author(s):  
Christine M. Crane ◽  
Joshua G. Pierce ◽  
Siegfried S. F. Leung ◽  
Julian Tirado-Rives ◽  
William L. Jorgensen ◽  
...  
Keyword(s):  
Methyl Ether ◽  
Derivatives Of ◽  
Vancomycin Aglycon
Sign in / Sign up

Export Citation Format

Share Document