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This review highlights the application of biopolymers of natural α-amino acids and its derived wild type
peptides employed as an organocatalysis for the asymmetric synthesis published by researchers across the globe is
described. The α-amino acids with L-stereochemistry are available commercial in pure form are played crucial role in
enantioselective chiral molecule synthesis. Out of twenty natural amino acids, only one secondary amine containing
proline amino acid exhibited revolution in the field of orgnocatalysis, because of its rigid structure and formation of an
imine like transition state during the reaction lead more stereoselectivity. Hence, it is referred to as a simple enzyme in
organocatalyst. Further discussed chiral organic molecule synthesis by employing oligopeptides derived from the natural
amino acids as a robust biocatalyst replaced enzyme catalysts. The peptide includes di-, tri, tetra-, penta- and oligopeptide
derived demonstrated as a potential organocatalysts, whose reaction activity and mechanistic pathways are reviewed.
Several choice of families of these organocatalysts permit chemist to achieve facile and efficient stereoselective synthesis
of many complex natural products with optically pure isomer. Subsequently, researcher developed green and sustainable
heterogeneous catalytic system containing organocatalyst immobilized onto solid inorganic supports or porous materials,
and is responsible for accelerating the reaction through heterogeneous phase. The developed heterogeneous
organocatalysts-MOFs found to be used easier and employed for bulk production and flow reactor synthesis. This review
compiled many outstanding discoveries in organocatalysts derived amino acids and it’s heterogenized on to MOFs
together role of the organocatalysis in many organic transformations in academic and industrial applications are covered.
Homochirality Is Originated from Handedness of Helices
