ChemInform Abstract: Total Synthesis of Brevetoxin A. Part 3. Construction of GHIJ and BCDE Ring Systems.

ChemInform ◽  
2010 ◽  
Vol 30 (23) ◽  
pp. no-no
Author(s):  
K. C. Nicolaou ◽  
et al. et al.
Keyword(s):  
Total Synthesis ◽  
Ring Systems ◽  
Brevetoxin A

Total Synthesis of Brevetoxin A: Part 3: Construction of GHIJ and BCDE Ring Systems

1999 ◽  
Vol 5 (2) ◽  
pp. 628-645 ◽  
Author(s):  
K. C. Nicolaou ◽  
Guo-qiang Shi ◽  
Janet L. Gunzner ◽  
Peter Gärtner ◽  
Paul A. Wallace ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Ring Systems ◽  
Brevetoxin A

ChemInform Abstract: Total Synthesis of Brevetoxin A. Part 1. First Generation Strategy and Construction of BCD Ring System.

ChemInform ◽  
2010 ◽  
Vol 30 (23) ◽  
pp. no-no
Author(s):  
K. C. Nicolaou ◽  
Mark E. Bunnage ◽  
Daniel G. McGarry ◽  
Shuhao Shi ◽  
Patricia K. Somers ◽  
...  
Keyword(s):  
Total Synthesis ◽  
First Generation ◽  
Ring System ◽  
Brevetoxin A

Total Synthesis of (–)-Alstofolinine A: Selected Furan Oxidation/ Cyclization Cascade

Synlett ◽  
2019 ◽  
Vol 31 (01) ◽  
pp. 7-12 ◽  
Author(s):  
Ye Zhang ◽  
Lei Zhang ◽  
Xiangbing Qi
Keyword(s):  
Total Synthesis ◽  
Common Core ◽  
Nucleophilic Addition ◽  
Addition Reaction ◽  
Indole Alkaloids ◽  
Indole Alkaloid ◽  
Asymmetric Total Synthesis ◽  
Ring Systems ◽  
Synthetic Strategy ◽  
Nucleophilic Addition Reaction

Indole-fused tetracyclic ring systems containing nitrogen atoms are common core skeletons of many indole alkaloids such as sarpagine, macroline, and ajmaline. Efficient and stereoselective construction of these ring systems can promote the development of the corresponding alkaloid syntheses. In this article, we briefly summarize our current progress toward the application of the aza-Achmatowicz reaction and indole nucleophilic addition reaction cascade for the first asymmetric total synthesis of the macroline-type indole alkaloid (–)-Alstofolinine A. Our synthetic strategy is based on furan oxidation/rearrangement and proceeds from easily accessible materials such as indole and furan derivatives.

scholarly journals Synthetic Approaches to Tetracyclic Pyrrole Imidazole Marine Alkaloids

2013 ◽  
Vol 8 (7) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Takuya Imaoka ◽  
Makoto Iwata ◽  
Takafumi Akimoto ◽  
Kazuo Nagasawa
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Anticancer Activity ◽  
Biological Activities ◽  
Structural Complexity ◽  
Marine Alkaloids ◽  
Ring Systems ◽  
Agonistic Activity ◽  
Synthetic Approaches

Oroidin derived pyrrole imidazole marine alkaloids (PIAs) are attractive targets for synthetic organic chemists because of their structural complexity and diversity as well as their interesting biological activities. A number of efforts have been carried out to develop strategies for the synthesis of these natural products. Members of PIAs ( eg., 2-7) which contain tetracyclic ring systems possessing characteristic cyclic guanidine or urea moieties show significant biological activities including anticancer activity and agonistic activity against the adrenoceptor. In this review investigations of the total synthesis of the representative tetracyclic PIAs dibromophakellin (2) and dibromophakellstatin (3) are described.

Total Synthesis of Brevetoxin A: Part 2: Second Generation Strategy and Construction of EFGH Model System

1999 ◽  
Vol 5 (2) ◽  
pp. 618-627 ◽  
Author(s):  
K. C. Nicolaou ◽  
Paul A. Wallace ◽  
Shuhao Shi ◽  
Michael A. Ouellette ◽  
Mark E. Bunnage ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Second Generation ◽  
Model System ◽  
Brevetoxin A

Diastereoselective Total Synthesis of (±)-Schindilactone A, Part 1: Construction of the ABC and FGH Ring Systems and Initial Attempts to Construct the CDEF Ring System

2012 ◽  
Vol 7 (10) ◽  
pp. 2321-2333 ◽  
Author(s):  
Tian-Wen Sun ◽  
Wei-Wu Ren ◽  
Qing Xiao ◽  
Ye-Feng Tang ◽  
Yan-Dong Zhang ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Ring System ◽  
Ring Systems

scholarly journals Condensed heteroaromatic ring systems. IX Total synthesis of aaptamine.

1986 ◽  
Vol 34 (7) ◽  
pp. 2760-2765 ◽  
Author(s):  
TAKAO SAKAMOTO ◽  
NORIO MIURA ◽  
YOSHINORI KONDO ◽  
HIROSHI YAMANAKA
Keyword(s):  
Total Synthesis ◽  
Ring Systems ◽  
Heteroaromatic Ring

Studies on the Total Synthesis of Lactonamycin:  Construction of Model ABCD Ring Systems

2006 ◽  
Vol 71 (6) ◽  
pp. 2434-2444 ◽  
Author(s):  
David A. Henderson ◽  
Philip N. Collier ◽  
Gregoire Pavé ◽  
Paula Rzepa ◽  
Andrew J. P. White ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Ring Systems

ChemInform Abstract: Enantioselective Total Synthesis of Brevetoxin A: Convergent Coupling Strategy and Completion.

ChemInform ◽  
2009 ◽  
Vol 40 (46) ◽  
Author(s):  
Michael T. Crimmins ◽  
J. Lucas Zuccarello ◽  
Patrick J. McDougall ◽  
J. Michael Ellis
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis ◽  
Brevetoxin A ◽  
Coupling Strategy
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