Synthetic Approaches to Tetracyclic Pyrrole Imidazole Marine Alkaloids
2013 ◽
Vol 8
(7)
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pp. 1934578X1300800
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Keyword(s):
Oroidin derived pyrrole imidazole marine alkaloids (PIAs) are attractive targets for synthetic organic chemists because of their structural complexity and diversity as well as their interesting biological activities. A number of efforts have been carried out to develop strategies for the synthesis of these natural products. Members of PIAs ( eg., 2-7) which contain tetracyclic ring systems possessing characteristic cyclic guanidine or urea moieties show significant biological activities including anticancer activity and agonistic activity against the adrenoceptor. In this review investigations of the total synthesis of the representative tetracyclic PIAs dibromophakellin (2) and dibromophakellstatin (3) are described.
2011 ◽
Vol 84
(6)
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pp. 1379-1390
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Keyword(s):
2021 ◽
Keyword(s):
2018 ◽
Vol 25
(10)
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pp. 1194-1240
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Keyword(s):
2018 ◽
Vol 14
◽
pp. 130-134
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Keyword(s):
2013 ◽
Vol 61
(8)
◽
pp. 781-798
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