ChemInform Abstract: Benzotriazol-1-yl-acetone as a Building Block in Heterocyclic Chemistry: A Route to Benzotriazolylpyridazines, Benzotriazolylphthalazines and Benzotriazolylpyrazolo[5,1-c]-1,2,4-triazines.

ChemInform ◽  
2010 ◽  
Vol 31 (8) ◽  
pp. no-no
Author(s):  
Abdul Aziz Al-Naggar ◽  
Mervat Mohammed Abdel-Khalik ◽  
Mohammed Hilmy Elnagdi
Keyword(s):  
Building Block ◽  
Heterocyclic Chemistry

scholarly journals Benzotriazol-1-yl-Acetone as a Building Block in Heterocyclic Chemistry: A Route to Benzotriazolylpyridazines, Benzotriazolylphthalazines and Benzotriazolylpyrazolo[5,1-c]-1,2,4-triazines

1999 ◽  
Vol 23 (11) ◽  
pp. 648-649
Author(s):  
Abdul Aziz Al-Naggar ◽  
Mervat Mohammed Abdel-Khalik ◽  
Mohammed Hilmy Elnagdi
Keyword(s):  
Double Bond ◽  
Building Block ◽  
Ethyl Cyanoacetate ◽  
Diazonium Salts ◽  
Heterocyclic Chemistry

Benzotriazolylacetone is coupled with aromatic diazonium salts to yield arylhydrazones, which can be condensed with ethyl cyanoacetate yielding pyridazinones whose reactivity towards activated double bond systems is investigated.

scholarly journals Synthesis and Anticancer Perspective of Pyridopyrimidine Scaffold - An Overview

2021 ◽  
pp. 438-461
Author(s):  
Chaithra R. Shetty ◽  
C. S. Shastry
Keyword(s):  
Carboxylic Acid ◽  
Anticancer Activity ◽  
Building Block ◽  
Heterocyclic Chemistry ◽  
Active Compounds ◽  
Pyridine Carboxylic Acid ◽  
Anticancer Properties ◽  
The Core ◽  
Wide Range ◽  
Pyridine Carboxylic

The core pyridopyrimidines are gaining interest in organic and heterocyclic chemistry in recent days, as this scaffold acts as a building block because of its wide range of biological and pharmacological applications like anticancer, antimicrobial, fungicidal, antiviral, CNS, antibacterial, and anti-inflammatory properties. This review mainly emphasizes the evolution in anticancer properties of pyridopyrimidines since 2008 especially the method of synthesis and anticancer activity of synthesized compounds with reporting of active anticancer scaffolds. Important starting materials which are widely used for the synthesis are 2-thioxopyrimidine, ethyl 2-cyanoacetate, 2-amino-3-cyano-4-trifluoromethyl-6-phenyl-pyridine, 2-amino-4,6-disubstituted nicotinonitrile, 2-chloro-3-pyridine carboxylic acid, in which 2-thioxopyrimidine is found to be mostly employed in the synthesis. Pyridopyrimidines which are synthesized from different starting materials, in which the more active compounds are reported here which may help in further discovery/ development of novel molecules.

Sign in / Sign up

Export Citation Format

Share Document