Three Polyoxygenated Steroids from the South China Sea Gorgonian Coral Subergorgia reticulata

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2011 ◽  
Vol 66 (6) ◽  
pp. 635-640
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Li-Si Huang ◽  
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...  

Four new steroidal glycosides and a new steriod linked with a 4-hydroxyphenylmethylene group, namely muricellasteroids A- E (1 - 5), together with one known steroidal glycoside analog, 22α,2ʹ,3ʹ,4ʹ-O-tetraacetyl-27-O-[β -D-arabino-pyranosyl-oxy]-20β -hydroxy-cholest-4- ene-3-one (6), were isolated from the EtOH/CH2Cl2 extracts of the South China Sea gorgonian coral Muricella flexuosa. The structures of 1 - 5 were established by means of 1D- and 2D-NMR and other spectroscopic analyses. Compounds 1 - 3 and 5 - 6 showed moderate cytotoxicity against A375, K562, and A549 cancer cell lines.


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