Palladium-Catalyzed Construction of Amino Acid Derivatives Possessing Vicinal Chiral Quaternary and Tertiary Carbon Centers at the α and β Positions.

ChemInform ◽  
2006 ◽  
Vol 37 (2) ◽  
Author(s):  
Daiji Ikeda ◽  
Motoi Kawatsura ◽  
Junichi Uenishi
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Carbon Centers ◽  
Tertiary Carbon ◽  
Palladium Catalyzed

Palladium‐Catalyzed Allylic Alkylation of Aldimine Esters with Vinyl‐Cyclopropanes to Yield α,α‐Disubstituted α‐Amino Acid Derivatives

2019 ◽  
Vol 361 (22) ◽  
pp. 5105-5111 ◽  
Author(s):  
Jiahua Wang ◽  
Zonghao Dai ◽  
Cheng Xiong ◽  
Jin Zhu ◽  
Jinrong Lu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Allylic Alkylation ◽  
Palladium Catalyzed

Palladium-Catalyzed Intermolecular Aminocarbonylation of Alkenes: Efficient Access of β-Amino Acid Derivatives

2015 ◽  
Vol 137 (7) ◽  
pp. 2480-2483 ◽  
Author(s):  
Jiashun Cheng ◽  
Xiaoxu Qi ◽  
Ming Li ◽  
Pinhong Chen ◽  
Guosheng Liu
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Efficient Access ◽  
Palladium Catalyzed

scholarly journals Directed, Nickel-Catalyzed Umpolung 1,2-Carboamination of Alkenyl Carbonyl Compounds

2018 ◽  
Author(s):  
Vincent van der Puyl ◽  
Joseph Derosa ◽  
Keary Engle
Keyword(s):  
Amino Acid ◽  
Tertiary Amine ◽  
Carbonyl Compounds ◽  
Amino Acid Derivatives ◽  
Quaternary Carbon ◽  
Carbon Centers ◽  
Two Component ◽  
Directing Group

We report a regioselective, nickel-catalyzed <i>syn</i>-1,2-carboamination of non-conjugated alkenyl carbonyl compounds with <i>O</i>-benzoyl hydroxylamine (N–O) electrophiles and aryl/alkylzinc nucleophiles to afford β- and γ-amino acid derivatives. This method enables preparation of products containing structurally diverse tertiary amine motifs, including heterocycles, and can also be used to form quaternary carbon centers. The reaction takes advantage of a tethered 8-aminoquinoline directing group to control the regiochemical outcome and suppress two-component coupling between the N–O electrophile and organozinc nucleophile.

scholarly journals Palladium-Catalyzed Diastereo- and Enantioselective Allylic Alkylation of Oxazolones with 1,3-Dienes Under Base-Free Conditions

2020 ◽  
Author(s):  
Haijian Yang ◽  
Dong Xing
Keyword(s):  
Catalytic System ◽  
Allylic Alkylation ◽  
Chiral Ligand ◽  
Palladium Hydride ◽  
Carbon Centers ◽  
Tertiary Carbon ◽  
Palladium Catalyzed

<p>Herein, we report a highly diastereo- and enantioselective allylic alkylation of oxozolones with 1,3-dienes by palladium-hydride catalyst under base-free conditions. With DTBM-SEGPHOS as the chiral ligand, a series of enantioenriched oxazolones bearing tertiary carbon centers were synthesized from substituted 1,3-dienes via exclusive 1,2-addition with moderate to good diastereoselectivities and high enantioselectivities. When simple 1,3-butadiene was used as the allyl precursor under this base-free catalytic system, 1,4-addition products were obtained in good yields with high regioselectivities. </p>

Synthesis of Chiral β-Fluoroalkyl β-Amino Acid Derivatives via Palladium-Catalyzed Hydrogenation

2019 ◽  
Vol 84 (16) ◽  
pp. 10371-10379 ◽  
Author(s):  
Mu-Wang Chen ◽  
Qin Yang ◽  
Zhihong Deng ◽  
Qiuping Ding ◽  
Yiyuan Peng
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Palladium Catalyzed

Palladium-Catalyzed Decarbonylation of Amino Acid Derivatives via C–C Bond and C–N Bond Dual Activations

2021 ◽  
Author(s):  
Jiamin Wu ◽  
Jinli Zhang ◽  
Yongjuan Jiao ◽  
Gongtao Deng ◽  
Yingmei Li ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Palladium Catalyzed
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