scholarly journals Cobalt(diamine)-Catalyzed Cross-Coupling Reaction of Alkyl Halides with Arylmagnesium Reagents: Stereoselective Constructions of Arylated Asymmetric Carbons and Application to Total Synthesis of AH13205.

ChemInform ◽  
2006 ◽  
Vol 37 (24) ◽  
Author(s):  
Hirohisa Ohmiya ◽  
Hideki Yorimitsu ◽  
Koichiro Oshima
Keyword(s):  
Total Synthesis ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Cross Coupling Reaction

Total Synthesis of (±)-Cassumunins A–C and Curcumin Analogues

Synthesis ◽  
2020 ◽  
Vol 52 (10) ◽  
pp. 1561-1575 ◽  
Author(s):  
Faiz Ahmed Khan ◽  
Mulla Althafh Hussain
Keyword(s):  
Total Synthesis ◽  
Claisen Rearrangement ◽  
Aldol Condensation ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Full Account ◽  
Curcumin Analogues ◽  
Cross Coupling Reaction ◽  
Sigmatropic Shift ◽  
Novel Approaches

A full account of the total synthesis of (±)-cassumunins A–C – superior antioxidants and anti-inflammatory agents – is given. Two novel approaches were developed for synthesizing cassumunins. The total synthesis of cassumunins A and B was accomplished in five linear steps from a known aldehyde in good overall yields of 50 and 43%, respectively, featuring a cascade [3,3]-sigmatropic shift (the Claisen rearrangement) and Heck cross-coupling reaction. Consequently, the total synthesis of cassumunin C was accomplished in three linear steps from a known alcohol with an overall yield of 53%. The key features involved in this synthesis are tandem [3,3]-sigmatropic shift, SN2′ reaction, and aldol condensation. Moreover, a total of eighteen symmetrical and unsymmetrical curcumin analogues were synthesized.

Copper-Catalyzed Cross-Coupling Reaction of Grignard Reagents with Primary-Alkyl Halides: Remarkable Effect of 1-Phenylpropyne

2007 ◽  
Vol 119 (12) ◽  
pp. 2132-2135 ◽  
Author(s):  
Jun Terao ◽  
Hirohisa Todo ◽  
Shameem Ara Begum ◽  
Hitoshi Kuniyasu ◽  
Nobuaki Kambe
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Remarkable Effect ◽  
Cross Coupling Reaction
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