ChemInform Abstract: Zirconyl Chloride Promoted Highly Efficient Solid Phase Synthesis of Amide Derivatives.

ChemInform ◽  
2008 ◽  
Vol 39 (22) ◽  
Author(s):  
Cherkupally Sanjeeva Reddy ◽  
Adki Nagaraj ◽  
Pochampally Jalapathi
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Zirconyl Chloride ◽  
Phase Synthesis ◽  
Highly Efficient ◽  
Amide Derivatives

Zirconyl chloride promoted highly efficient solid phase synthesis of amide derivatives

2007 ◽  
Vol 18 (10) ◽  
pp. 1213-1217 ◽  
Author(s):  
Cherkupally Sanjeeva Reddy ◽  
Adki Nagaraj ◽  
Pochampally Jalapathi
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Zirconyl Chloride ◽  
Phase Synthesis ◽  
Highly Efficient ◽  
Amide Derivatives

scholarly journals Solid Phase Syntheses of Ferulic Acid Derivatives Acetyl Feruloyl Tyrosine and Acetyl Feruloyl Valyl Tyrosine

2015 ◽  
Vol 9 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Dongxin Zhao ◽  
Li Ma ◽  
Kui Lu ◽  
Juan He
Keyword(s):  
Ferulic Acid ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Acid Amide ◽  
Synthesis Method ◽  
Amide Bond ◽  
Peptide Transporter ◽  
Phase Synthesis ◽  
Amide Derivatives ◽  
Fmoc Solid Phase Synthesis

Ferulic acid was used as a common drug for cardia-cerebrovascular disease and leukopenia, but the application of ferulic acid was inhibited by the poor absorption and stability. The improvement of these defects can be realized by modifying ferulic acid by amino acids, because the amido bond can increase the bioavailability and therapeutic effect of some drugs based on the peptide transporter system of mammalian which can transport the peptidyl drugs. The peptidyl derivatives of ferulic acid, namely acetyl feruloyl tyrosine and acetyl feruloyl valyl tyrosine, were synthesized using Fmoc solid-phase synthesis method. The synthesized ferulic acid amide derivatives were purified by RP-HPLC, and characterized by IR, HNMR and ESI-MS. The results indicated that Fmoc solid phase synthesis was a convenient method for the amide bond modification of ferulic acid and the further property research on ferulic acid derivatives.

scholarly journals Synthesis of homo- and heteromultivalent carbohydrate-functionalized oligo(amidoamines) using novel glyco-building blocks

2013 ◽  
Vol 9 ◽  
pp. 2395-2403 ◽  
Author(s):  
Felix Wojcik ◽  
Sinaida Lel ◽  
Alexander G O’Brien ◽  
Peter H Seeberger ◽  
Laura Hartmann
Keyword(s):  
Double Bond ◽  
Building Block ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Building Blocks ◽  
Phase Synthesis ◽  
Highly Efficient ◽  
Monomer Sequence ◽  
Full Control ◽  
Block Approach

We present the solid phase synthesis of carbohydrate-functionalized oligo(amidoamines) with different functionalization patterns utilizing a novel alphabet of six differently glycosylated building blocks. Highly efficient in flow conjugation of thioglycosides to a double-bond presenting diethylentriamine precursor is the key step to prepare these building blocks suitable for fully automated solid-phase synthesis. Introduction of the sugar ligands via functionalized building blocks rather than postfunctionalization of the oligomeric backbone allows for the straightforward synthesis of multivalent glycoligands with full control over monomer sequence and functionalization pattern. We demonstrate the potential of this building-block approach by synthesizing oligomers with different numbers and spacing of carbohydrates and also show the feasibility of heteromultivalent glycosylation patterns by combining building blocks presenting different mono- and disaccharides.

A highly efficient in situ N-acetylation approach for solid phase synthesis

2014 ◽  
Vol 12 (12) ◽  
pp. 1879-1884 ◽  
Author(s):  
Koushik Chandra ◽  
Tapta Kanchan Roy ◽  
Johnny N. Naoum ◽  
Chaim Gilon ◽  
R. Benny Gerber ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Highly Efficient

In situ peptide acetylation.

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