ChemInform Abstract: DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

10.1002/chin.200946270 ◽

2009 ◽

Vol 40 (46) ◽

Author(s):

Yves Pommier

Keyword(s):

Topoisomerase I ◽

Dna Topoisomerase I ◽

Dna Topoisomerase ◽

Topoisomerase I Inhibitors

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Mode of inhibition of eukaryotic DNA topoisomerase I inhibitors.

Nippon Nōgeikagaku Kaishi ◽

10.1271/nogeikagaku1924.65.1008 ◽

1991 ◽

Vol 65 (6) ◽

pp. 1008-1010

Author(s):

Hiro-omi TAMURA ◽

Yoji IKEGAMI

Keyword(s):

Topoisomerase I ◽

Dna Topoisomerase I ◽

Dna Topoisomerase ◽

Topoisomerase I Inhibitors ◽

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ChemInform Abstract: Amphimic Acids, Novel Unsaturated C28 Fatty Acids as DNA Topoisomerase I Inhibitors from an Australian Sponge Amphimedon sp.

10.1002/chin.199743252 ◽

2010 ◽

Vol 28 (43) ◽

pp. no-no

Author(s):

T. NEMOTO ◽

M. OJIKA ◽

Y. SAKAGAMI

Keyword(s):

Fatty Acids ◽

Topoisomerase I ◽

Dna Topoisomerase I ◽

Dna Topoisomerase ◽

Topoisomerase I Inhibitors

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p16INK4Expression Is Associated with the Increased Sensitivity of Human Non-small Cell Lung Cancer Cells to DNA Topoisomerase I Inhibitors

Japanese Journal of Cancer Research ◽

10.1111/j.1349-7006.1997.tb00322.x ◽

1997 ◽

Vol 88 (10) ◽

pp. 1009-1016 ◽

Author(s):

Kazuya Fukuoka ◽

Jun-ichi Adachi ◽

Kazuto Nishio ◽

Hitoshi Arioka ◽

Hirokazu Kurokawa ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cancer Cells ◽

Topoisomerase I ◽

Dna Topoisomerase I ◽

Small Cell Lung ◽

Dna Topoisomerase ◽

Topoisomerase I Inhibitors ◽

Increased Sensitivity

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Synthesis and Pharmacological Evaluation of Novel Homocamptothecin-Dihydropyridine Derivative Conjugates as Potent Topoisomerase I Inhibitors

Australian Journal of Chemistry ◽

10.1071/ch11091 ◽

2011 ◽

Vol 64 (10) ◽

pp. 1390 ◽

Author(s):

Ling-Jian Zhu ◽

Chun-Lin Zhuang ◽

Ning Lei ◽

Chun-Quan Sheng ◽

Wei Guo ◽

...

Keyword(s):

Topoisomerase I ◽

Antitumour Activity ◽

Tumour Cell Line ◽

Dna Topoisomerase I ◽

Inhibition Activity ◽

Dna Topoisomerase ◽

Antitumour Agents ◽

Topoisomerase I Inhibitors ◽

Dihydropyridine Derivative ◽

Homocamptothecins (hCPT) represent a new generation of antitumour agents targeting DNA topoisomerase I. The expanded seven-membered lactone E-ring that characterizes hCPT enhances the plasma stability of the drug and reinforces the inhibition of topoisomerase I (Topo I) compared with conventional six-membered CPT. In an attempt to improve the antitumour activity of hCP, a series of novel hCPT derivatives conjugating with dihydropyridine derivates were designed and synthesized based on a synthetic route that couples 7-formylhomocamptothecin with different dihydropyridine derivates. Most of the synthesized compounds exhibited good cytotoxic activity on tumour cell line A549, MDA-MB-435, and HCT116. Furthermore, this class of compounds showed superior Topo I inhibition activity comparable to or higher than CPT.

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Hypersensitivity of NIH3T3 cells transformed by H-RAS gene to DNA-topoisomerase-I inhibitors

International Journal of Cancer ◽

10.1002/(sici)1097-0215(19960904)67:5<702::aid-ijc19>3.0.co;2-6 ◽

1996 ◽

Vol 67 (5) ◽

pp. 702-708 ◽

Author(s):

Tatsuo Ohira ◽

Kazuto Nishio ◽

Fumihiko Kanzawa ◽

Tomoyuki Ishida ◽

Yuichiro Ohe ◽

...

Keyword(s):

Topoisomerase I ◽

Dna Topoisomerase I ◽

Ras Gene ◽

Dna Topoisomerase ◽

Nih3t3 Cells ◽

Topoisomerase I Inhibitors

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ChemInform Abstract: Amphimic Acids and Related Long-Chain Fatty Acids as DNA Topoisomerase I Inhibitors from an Australian Sponge, Amphimedon sp.: Isolation, Structure, Synthesis, and Biological Evaluation.

10.1002/chin.199810250 ◽

2010 ◽

Vol 29 (10) ◽

pp. no-no

Author(s):

T. NEMOTO ◽

G. YOSHINO ◽

M. OJIKA ◽

Y. SAKAGAMI

Keyword(s):

Fatty Acids ◽

Topoisomerase I ◽

Biological Evaluation ◽

Dna Topoisomerase I ◽

Long Chain Fatty Acids ◽

Dna Topoisomerase ◽

Topoisomerase I Inhibitors ◽

Structure Synthesis ◽

Synthesis And Biological Evaluation ◽

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Amphimic acids, novel unsaturated C28 fatty acids as DNA topoisomerase I inhibitors from an Australian sponge Amphimedon sp.

Tetrahedron Letters ◽

10.1016/s0040-4039(97)01234-3 ◽

1997 ◽

Vol 38 (32) ◽

pp. 5667-5670 ◽

Author(s):

Takayuki Nemoto ◽

Makoto Ojika ◽

Youji Sakagami

Keyword(s):

Fatty Acids ◽

Topoisomerase I ◽

Dna Topoisomerase I ◽

Dna Topoisomerase ◽

Topoisomerase I Inhibitors

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Amphimic acids and related long-chain fatty acids as DNA topoisomerase I inhibitors from an Australian sponge, Amphimedon sp.: Isolation, structure, synthesis, and biological evaluation

Tetrahedron ◽

10.1016/s0040-4020(97)10099-0 ◽

1997 ◽

Vol 53 (49) ◽

pp. 16699-16710 ◽

Author(s):

Takayuki Nemoto ◽

Go Yoshino ◽

Makoto Ojika ◽

Youji Sakagami

Keyword(s):

Fatty Acids ◽

Topoisomerase I ◽

Biological Evaluation ◽

Dna Topoisomerase I ◽

Long Chain Fatty Acids ◽

Dna Topoisomerase ◽

Topoisomerase I Inhibitors ◽

Structure Synthesis ◽

Synthesis And Biological Evaluation ◽

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ChemInform Abstract: Synthesis of Topostins B567 and D654 (WB-3559D, Flavolipin), DNA Topoisomerase I Inhibitors of Bacterial Origin.

10.1002/chin.199918223 ◽

2010 ◽

Vol 30 (18) ◽

pp. no-no

Author(s):

Takayuki Shioiri ◽

Yoshihiro Terao ◽

Naoko Irako ◽

Toyohiko Aoyama

Keyword(s):

Topoisomerase I ◽

Dna Topoisomerase I ◽

Dna Topoisomerase ◽

Topoisomerase I Inhibitors ◽

Bacterial Origin

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Rigid Analogs of Camptothecin as DNA Topoisomerase I Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm00006a008 ◽

1995 ◽

Vol 38 (6) ◽

pp. 906-911 ◽

Author(s):

Karen Lackey ◽

Jeffrey M. Besterman ◽

Wade Fletcher ◽

Peter Leitner ◽

Bradley Morton ◽

...

Keyword(s):

Topoisomerase I ◽

Dna Topoisomerase I ◽

Dna Topoisomerase ◽

Topoisomerase I Inhibitors

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