ChemInform Abstract: 5-Aminouracil as a Building Block in Heterocyclic Synthesis. Part 2. One-Pot Synthesis of Pyrido[3,2-d:6,5-d′]dipyrimidines under Microwave Irradiation Without Catalyst.

An efficient and direct procedure for the synthesis of pyrido[3,2-d:6,5-dʹ]dipyrimidine derivatives under microwave-assisted conditions is been described. The structures of the products were characterized by elemental analyses, and their IR, 1H NMR, 13C NMR, and MS spectra.

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5-Aminouracil as a Building Block in Heterocyclic Synthesis: Part IV. One-pot Synthesis of 1H-Pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione Derivatives Using Controlled Microwave Heating

Zeitschrift für Naturforschung B ◽

10.1515/znb-2011-0810 ◽

2011 ◽

Vol 66 (8) ◽

pp. 843-849

Author(s):

Raafat M. Shaker ◽

Kamal U. Sadek ◽

Ebtisam A. Hafez ◽

Mohamed Abd Elrady

Keyword(s):

Microwave Heating ◽

Building Block ◽

Heterocyclic Synthesis ◽

One Pot ◽

H Nmr ◽

One Pot Synthesis ◽

Elemental Analyses ◽

C Nmr

An efficient and direct procedure for the synthesis of pyrrolo[2,3-d]pyrimidine-2,4-dione derivatives using controlled microwave heating has been described. The products were characterized by elemental analyses, IR, 1H NMR, 13C NMR and MS spectra.

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5-Aminouracil as a Building Block in Heterocyclic Synthesis: Part III. One-pot Synthesis of Novel Pyrimido[5,4-b]quinoline-2,4,9-triones and Pyrimido[5,4-c]isoquinolines

Zeitschrift für Naturforschung B ◽

10.1515/znb-2010-1212 ◽

2010 ◽

Vol 65 (12) ◽

pp. 1485-1490 ◽

Cited By ~ 3

Author(s):

Raafat M. Shaker ◽

Kamal U. Sadek ◽

Ebtisam A. Hafez ◽

Mohamed Abd Elrady

Keyword(s):

Building Block ◽

Heterocyclic Synthesis ◽

One Pot ◽

H Nmr ◽

One Pot Synthesis ◽

Elemental Analyses ◽

Isoquinoline Derivatives ◽

C Nmr

An efficient and direct procedure for the synthesis of pyrimido[5,4-b]quinoline-2,4,9-trione and pyrimido[5,4-c]isoquinoline derivatives has been described. The products were characterized by elemental analyses, IR, 1H NMR, 13C NMR and MS spectra.

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5-Aminouracil as a Building Block in Heterocyclic Synthesis: Part I. One-pot Synthesis of Pyrimido[5,4-b]quinolin-2,4,9-triones under Microwave Irradiation without Catalyst

Zeitschrift für Naturforschung B ◽

10.1515/znb-2008-1215 ◽

2008 ◽

Vol 63 (12) ◽

pp. 1431-1437 ◽

Cited By ~ 6

Author(s):

Raafat M. Shaker ◽

Mohamed Abd Elrady

Keyword(s):

Microwave Irradiation ◽

Potassium Carbonate ◽

Building Block ◽

Anhydrous Potassium Carbonate ◽

Nmr Spectra ◽

Heterocyclic Synthesis ◽

One Pot ◽

One Pot Condensation ◽

Elemental Analyses ◽

C Nmr

A series of 6,7,8,10-tetrahydropyrimido[5,4-b]quinolin-2,4,9-(1H,3H,5H)-triones 6 were synthesized through one-pot condensation of 5-aminouracil, aldehydes and dimedone in DMF under microwave irradiation without catalyst. The products 6a, d were oxidized to the 7,8-dihydro-pyrimido- [5,4-b]quinolin-2,4,9-(1H,3H,6H)-triones 11a, b. Treatment of 6a, d and/or 11a, b with ethyl iodide in the presence of anhydrous potassium carbonate gave the ethylated derivatives 12a, b and 13a, b, respectively. The structures of the products were confirmed by elemental analyses, IR, MS, 1H, and 13C NMR spectra.

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