5-Aminouracil as a Building Block in Heterocyclic Synthesis: Part IV. One-pot Synthesis of 1H-Pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione Derivatives Using Controlled Microwave Heating

2011 ◽  
Vol 66 (8) ◽  
pp. 843-849
Author(s):  
Raafat M. Shaker ◽  
Kamal U. Sadek ◽  
Ebtisam A. Hafez ◽  
Mohamed Abd Elrady
Keyword(s):  
Microwave Heating ◽  
Building Block ◽  
Heterocyclic Synthesis ◽  
One Pot ◽  
H Nmr ◽  
One Pot Synthesis ◽  
Elemental Analyses ◽  
C Nmr

An efficient and direct procedure for the synthesis of pyrrolo[2,3-d]pyrimidine-2,4-dione derivatives using controlled microwave heating has been described. The products were characterized by elemental analyses, IR, 1H NMR, 13C NMR and MS spectra.

scholarly journals 5-Aminouracil as a Building Block in Heterocyclic Synthesis: Part III. One-pot Synthesis of Novel Pyrimido[5,4-b]quinoline-2,4,9-triones and Pyrimido[5,4-c]isoquinolines

2010 ◽  
Vol 65 (12) ◽  
pp. 1485-1490 ◽  
Author(s):  
Raafat M. Shaker ◽  
Kamal U. Sadek ◽  
Ebtisam A. Hafez ◽  
Mohamed Abd Elrady
Keyword(s):  
Building Block ◽  
Heterocyclic Synthesis ◽  
One Pot ◽  
H Nmr ◽  
One Pot Synthesis ◽  
Elemental Analyses ◽  
Isoquinoline Derivatives ◽  
C Nmr

An efficient and direct procedure for the synthesis of pyrimido[5,4-b]quinoline-2,4,9-trione and pyrimido[5,4-c]isoquinoline derivatives has been described. The products were characterized by elemental analyses, IR, 1H NMR, 13C NMR and MS spectra.

5-Aminouracil as a Building Block in Heterocyclic Synthesis: Part I. One-pot Synthesis of Pyrimido[5,4-b]quinolin-2,4,9-triones under Microwave Irradiation without Catalyst

2008 ◽  
Vol 63 (12) ◽  
pp. 1431-1437 ◽  
Author(s):  
Raafat M. Shaker ◽  
Mohamed Abd Elrady
Keyword(s):  
Microwave Irradiation ◽  
Potassium Carbonate ◽  
Building Block ◽  
Anhydrous Potassium Carbonate ◽  
Nmr Spectra ◽  
Heterocyclic Synthesis ◽  
One Pot ◽  
One Pot Condensation ◽  
Elemental Analyses ◽  
C Nmr

A series of 6,7,8,10-tetrahydropyrimido[5,4-b]quinolin-2,4,9-(1H,3H,5H)-triones 6 were synthesized through one-pot condensation of 5-aminouracil, aldehydes and dimedone in DMF under microwave irradiation without catalyst. The products 6a, d were oxidized to the 7,8-dihydro-pyrimido- [5,4-b]quinolin-2,4,9-(1H,3H,6H)-triones 11a, b. Treatment of 6a, d and/or 11a, b with ethyl iodide in the presence of anhydrous potassium carbonate gave the ethylated derivatives 12a, b and 13a, b, respectively. The structures of the products were confirmed by elemental analyses, IR, MS, 1H, and 13C NMR spectra.

5-Aminouracil as a Building Block in Heterocyclic Synthesis, Part II. One-pot Synthesis of Pyrido[3,2-d:6,5-dʹ]dipyrimidines under Microwave Irradiation without Catalyst

2009 ◽  
Vol 64 (10) ◽  
pp. 1193-1198 ◽  
Author(s):  
Raafat M. Shaker ◽  
Mohamed A. Ameen ◽  
Afaf M. Abdel Hameed ◽  
Mohamed Abd Elrady
Keyword(s):  
Microwave Irradiation ◽  
1H Nmr ◽  
13C Nmr ◽  
Building Block ◽  
Heterocyclic Synthesis ◽  
One Pot ◽  
Microwave Assisted ◽  
One Pot Synthesis ◽  
Elemental Analyses

An efficient and direct procedure for the synthesis of pyrido[3,2-d:6,5-dʹ]dipyrimidine derivatives under microwave-assisted conditions is been described. The structures of the products were characterized by elemental analyses, and their IR, 1H NMR, 13C NMR, and MS spectra.

scholarly journals An Efficient One Pot Synthesis of some New 1,4-Dihydropyridine Derivatives Using Multicomponent Reaction

2015 ◽  
Vol 57 ◽  
pp. 45-50
Author(s):  
Devang R. Prajapati ◽  
Hardik K. Senjani ◽  
Yogesh T. Naliapara
Keyword(s):  
Nmr Spectroscopy ◽  
Multicomponent Reaction ◽  
Elemental Analysis ◽  
One Pot ◽  
H Nmr ◽  
One Pot Synthesis ◽  
Target Molecules ◽  
Dihydropyridine Derivatives ◽  
C Nmr

Synthesize target molecules, multicomponent reaction of 4-(4-aminophenyl) morpholin-3-one with various pyrazole aldehydes and ethylacetoacetate or methylacetoacetate afforded various 1,4-dihydropyridines derivatives. The newly synthesized compounds were characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis.

scholarly journals Simple and Efficient Three Component One-Pot Synthesis of Pyrazolo[1,5,a]Pyrimidines

2014 ◽  
Vol 41 ◽  
pp. 73-81
Author(s):  
Anil R. Morabia ◽  
Yogesh T. Naliapara
Keyword(s):  
Fourier Transform ◽  
Boric Acid ◽  
Elemental Analysis ◽  
One Pot ◽  
Aryl Aldehydes ◽  
H Nmr ◽  
Reaction Condition ◽  
One Pot Synthesis ◽  
C Nmr ◽  
Operational Simplicity

A series of novel 5-(2-bromophenyl)-N-cyclohexyl-2-(methylthio)-6-nitro-7-phenyl-4,7-dihydropyrazolo [1,5-a] pyrimidine-3-carboxamides were synthesized by a one-pot reaction of 5-amino-N-cyclohexyl-3-(methylthio)-1H-pyrazole-4-carboxamide, 1-(2-bromophenyl)-2-nitroethanone and aryl aldehydes in the presence of boric acid in water at refluxing temperature. Structures of compounds were demonstrated by Fourier transform infrared, 1H NMR, 13C NMR and elemental analysis. The advantages of this method are mild reaction condition, good yields, and operational simplicity.

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