ChemInform Abstract: Protein Kinases CK1 and CK2 as New Targets for Neurodegenerative Diseases

ChemInform ◽  
2012 ◽  
Vol 43 (9) ◽  
pp. no-no
Author(s):  
Daniel I. Perez ◽  
Carmen Gil ◽  
Ana Martinez
Keyword(s):  
Neurodegenerative Diseases ◽  
Protein Kinases ◽  
New Targets

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases

2010 ◽  
Vol 31 (6) ◽  
pp. 924-954 ◽  
Author(s):  
Daniel I. Perez ◽  
Carmen Gil ◽  
Ana Martinez
Keyword(s):  
Neurodegenerative Diseases ◽  
Protein Kinases ◽  
New Targets

Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases

2015 ◽  
Vol 21 (25) ◽  
pp. 3570-3581 ◽  
Author(s):  
Charles Finsterwald ◽  
Pierre Magistretti ◽  
Sylvain Lengacher
Keyword(s):  
Neurodegenerative Diseases ◽  
New Targets

scholarly journals Atypical (RIO) protein kinases from Haemonchus contortus — Promise as new targets for nematocidal drugs

2011 ◽  
Vol 29 (3) ◽  
pp. 338-350 ◽  
Author(s):  
Bronwyn E. Campbell ◽  
Peter R. Boag ◽  
Andreas Hofmann ◽  
Cinzia Cantacessi ◽  
Conan K. Wang ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Haemonchus Contortus ◽  
New Targets

scholarly journals Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements.

2009 ◽  
Vol 56 (2) ◽  
Author(s):  
Joanna Szczepanowska
Keyword(s):  
Neurodegenerative Diseases ◽  
Protein Kinases ◽  
Small Gtpases ◽  
Cytoskeletal Reorganization ◽  
Cellular Processes ◽  
Cytoskeletal Structure ◽  
Binding Partners ◽  
Evolutionarily Conserved ◽  
Cytoskeletal Rearrangements

The p21-activated kinases (PAKs) are serine/threonine protein kinases interacting with small GTPases - Rac and Cdc42. PAKs are found in most eukaryotes and play an evolutionarily conserved role in many cellular processes. Six human PAKs have been identified, and based on homology, they can be classified into two groups. This review focuses specifically on the role of Rac/Cdc42 regulated PAKs in maintaining and remodeling cytoskeletal structure in various organisms. A list of PAKs substrates and binding partners implicated directly and indirectly in cytoskeletal reorganization is presented. Also perturbations of the Rac/Cdc42/PAK pathway leading to tumorigenesis and neurodegenerative diseases are reviewed.

Sign in / Sign up

Export Citation Format

Share Document