ChemInform Abstract: An Efficient One-Pot Synthesis of Pyrimido[2,1-b][1,3]oxazine Derivatives via the Reaction of Isocyanides with Dialkyl Acetylenedicarboxylates in the Presence of 5-Substituted Uracils.
The highly reactive 1:1 intermediate produced in the reaction between tert-butyl isocyanide and dialkyl acetylenedicarboxylates is trapped by dialkyl 2-bromomalonates to yield the title compounds in fairly high yields.
A new and efficient one-pot synthesis of polysubstituted pyrrole derivatives by three-component reaction between dialkyl acetylenedicarboxylates, triphenylphosphine, 2-aminopyridin derivatives in the presence of arylglyoxals is described. The reactions were performed in dichloromethane at room temperature and neutral conditions and afforded high yields of products.
A New and Efficient One-pot Synthesis of Trialkyl 6-tert-Butylamino-2H-pyran-2-one-3,4,5-tricarboxylates