ChemInform Abstract: One-Step Synthesis of Reusable, Polymer-Supported Trialkyl Phosphine Ligands. Application in Suzuki-Miyaura and Alkoxycarbonylation Reactions.

ChemInform ◽  
2012 ◽  
Vol 43 (45) ◽  
pp. no-no
Author(s):  
Ehsan Ullah ◽  
James McNulty ◽  
Marcin Sliwinski ◽  
Al Robertson
Keyword(s):  
Phosphine Ligands ◽  
One Step ◽  
Polymer Supported

The polymer-supported sulfonic acid catalyzed one-step synthesis of diaminotriphenylmethanes

2008 ◽  
Vol 77 (2) ◽  
pp. 478-480 ◽  
Author(s):  
Li-Tao An ◽  
Fei-Qing Ding ◽  
Jian-Ping Zou
Keyword(s):  
Sulfonic Acid ◽  
One Step ◽  
Acid Catalyzed ◽  
Polymer Supported

scholarly journals Cu-Catalyzed Hydroboration of Benzylidenecyclopropanes: Reaction Optimization, (Hetero)Aryl Scope, and Origins of Pathway Selectivity

2019 ◽  
Author(s):  
Jose Medina ◽  
Taeho Kang ◽  
Tuğçe Erbay ◽  
Huiling Shao ◽  
Gary Gallego ◽  
...  
Keyword(s):  
Phosphine Ligands ◽  
Computational Studies ◽  
Reaction Conditions ◽  
Clinical Drug Development ◽  
Reaction Optimization ◽  
Relative Activation ◽  
One Step ◽  
Synthetic Intermediates ◽  
Insight Into ◽  
Clinical Drug

The copper-catalyzed hydroboration of benzylidenecyclopropanes, conveniently accessed in one step from readily available benzaldehydes, is reported. Under otherwise identical reaction conditions, two distinct phosphine ligands grant access to different products by either suppressing or promoting cyclopropane opening via β-carbon elimination. Computational studies provide insight into how the rigidity and steric environment of these different bis-phosphine ligands influence the relative activation energies of β-carbon elimination versus protodecupration from the key benzylcopper intermediate. The method tolerates a wide variety of heterocycles prevalent in clinical and pre-clinical drug development, giving access to valuable synthetic intermediates. The versatility of the tertiary cyclopropylboronic ester products is demonstrated through several derivatization reactions.

Soluble polymer-supported hindered phosphine ligands for palladium-catalyzed aryl amination

2015 ◽  
Vol 5 (4) ◽  
pp. 2378-2383 ◽  
Author(s):  
Tatyana V. Khamatnurova ◽  
Dongmei Zhang ◽  
Jakkrit Suriboot ◽  
Hassan S. Bazzi ◽  
David E. Bergbreiter
Keyword(s):  
Phosphine Ligands ◽  
Soluble Polymer ◽  
Soluble Polymers ◽  
Aryl Amination ◽  
Palladium Catalyzed ◽  
Polymer Supported

Two structurally different heptane soluble polymers – polyisobutylene and poly(4-alkylstyrene) – are shown to be good supports for hindered biaryldicyclohexyl phosphine Pd(0) aryl amination catalysts.

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