ChemInform Abstract: Ligand-Free Palladium/Copper Co-Catalyzed Direct Arylation of Polyfluoroarenes with Aryl Iodides.

New reaction conditions for the direct arylation of polyfluoroarenes with aryl iodides have been developed. This reaction can be co-catalyzed by palladium=copper without ligands and exhibits excellent functional group compatibility.

Download Full-text

Ligand-Free Pd-Catalyzed and Copper-Assisted C–H Arylation of Quinazolin-4-ones with Aryl Iodides under Microwave Heating

Organic Letters ◽

10.1021/acs.orglett.5b00467 ◽

2015 ◽

Vol 17 (7) ◽

pp. 1700-1703 ◽

Cited By ~ 36

Author(s):

Sylvain Laclef ◽

Marine Harari ◽

Julien Godeau ◽

Isabelle Schmitz-Afonso ◽

Laurent Bischoff ◽

...

Keyword(s):

Microwave Heating ◽

Aryl Iodides ◽

Ligand Free

Download Full-text

A highly efficient copper and ligand free protocol for the room temperature Sonogashira reaction

RSC Advances ◽

10.1039/c4ra09630d ◽

2015 ◽

Vol 5 (1) ◽

pp. 16-19 ◽

Cited By ~ 16

Author(s):

Ankur Gogoi ◽

Anindita Dewan ◽

Utpal Bora

Keyword(s):

Catalytic System ◽

Room Temperature ◽

Sonogashira Reaction ◽

Highly Efficient ◽

Aryl Iodides ◽

Ligand Free

A mild and efficient catalytic system based on PdCl2 and Na2SO4 has been developed for the Sonogashira reaction of aryl iodides at room temperature.

Download Full-text

Ligand-free Cu-catalyzed O-arylation of aliphatic diols

RSC Advances ◽

10.1039/c5ra12529d ◽

2015 ◽

Vol 5 (81) ◽

pp. 66104-66108 ◽

Cited By ~ 5

Author(s):

Yufen Zheng ◽

Wenxing Zou ◽

Laichun Luo ◽

Jiabei Chen ◽

Songwen Lin ◽

...

Keyword(s):

Copper Catalyst ◽

Scale Up ◽

Coupling Reaction ◽

Aryl Iodides ◽

Ligand Free

Coupling reaction between aryl iodides with aliphatic diols was realized with a ligand-free copper catalyst. This method was successfully applied in the process of scale-up synthesis of medicinal candidate product EMB-3.

Download Full-text

Efficient ligand-free copper-catalyzed C–S cross-coupling of thiols with aryl iodides using KF/Al2O3 as base

Tetrahedron Letters ◽

10.1016/j.tetlet.2010.02.155 ◽

2010 ◽

Vol 51 (18) ◽

pp. 2489-2492 ◽

Cited By ~ 42

Author(s):

Yi-Si Feng ◽

Yuan-Yuan Li ◽

Lin Tang ◽

Wei Wu ◽

Hua-Jian Xu

Keyword(s):

Cross Coupling ◽

Aryl Iodides ◽

Ligand Free

Download Full-text

Ligand-Free CuI-Catalyzed Chemoselective S-Arylation of 2-Mercaptobenzimidazole with Aryl Iodides

Synlett ◽

10.1055/s-0037-1610655 ◽

2018 ◽

Vol 29 (15) ◽

pp. 2056-2060 ◽

Cited By ~ 4

Author(s):

Yong-Chua Teo ◽

Bryan Tan

Keyword(s):

Cross Coupling ◽

Efficient Strategy ◽

Aryl Iodides ◽

Ligand Free ◽

Optimized Conditions

A practical and efficient strategy for the chemoselective C–S cross-coupling of 2-mercaptobenzimidazole derivatives with a range of substituted aryl iodides is described. Under the optimized conditions of 5 mol% CuI and 100 °C, a variety of S-arylated products were obtained in good to excellent yields (up to 92 %) without the need for assisting ligands.

Download Full-text