Synthesis, Labeling and Preclinical Evaluation of a Squaric Acid Containing PSMA Inhibitor Labeled with 68 Ga: A Comparison with PSMA‐11 and PSMA‐617

ChemMedChem ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. 695-704 ◽  
Author(s):  
Lukas Greifenstein ◽  
Nils Engelbogen ◽  
Hanane Lahnif ◽  
Jean‐Philippe Sinnes ◽  
Ralf Bergmann ◽  
...  
Keyword(s):  
Squaric Acid ◽  
Preclinical Evaluation ◽  
Psma Inhibitor

Preclinical Evaluation of a Tailor-Made DOTA-Conjugated PSMA Inhibitor with Optimized Linker Moiety for Imaging and Endoradiotherapy of Prostate Cancer

2015 ◽  
Vol 56 (6) ◽  
pp. 914-920 ◽  
Author(s):  
M. Bene ova ◽  
M. Schafer ◽  
U. Bauder-Wust ◽  
A. Afshar-Oromieh ◽  
C. Kratochwil ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Preclinical Evaluation ◽  
Psma Inhibitor

Synthesis and labeling of a squaric acid containing PSMA-inhibitor coupled to AAZTA5 for versatile labeling with 44Sc, 64Cu, 68Ga and 177Lu

2020 ◽  
Vol 156 ◽  
pp. 108867
Author(s):  
Lukas Greifenstein ◽  
Tilmann Grus ◽  
Johannes Nagel ◽  
Jean Phillip Sinnes ◽  
Frank Rösch
Keyword(s):  
Squaric Acid ◽  
Psma Inhibitor

Synthesis and preclinical evaluation of the 177Lu-DOTA-PSMA(inhibitor)-Lys3-bombesin heterodimer designed as a radiotheranostic probe for prostate cancer

2019 ◽  
Vol 40 (3) ◽  
pp. 278-286 ◽  
Author(s):  
Alondra Escudero-Castellanos ◽  
Blanca Ocampo-García ◽  
Guillermina Ferro-Flores ◽  
Clara Santos-Cuevas ◽  
Enrique Morales-Ávila ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Preclinical Evaluation ◽  
Psma Inhibitor

Contact immunotherapy with squaric acid dibutylester for the treatment of recalcitrant warts☆, ☆☆, ★

1999 ◽  
Vol 41 (4) ◽  
pp. 595-599 ◽  
Author(s):  
A LEE ◽  
S MALLORY
Keyword(s):  
Squaric Acid

Preclinical evaluation of red grapes seeds extract from Vitis vinifera, Burgund Mare, Recas, Romania as skin photochemoprotective agent

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
P Bolfa ◽  
F Sarac ◽  
A Filip ◽  
A Gal ◽  
M Taulescu ◽  
...  
Keyword(s):  
Vitis Vinifera ◽  
Red Grapes ◽  
Preclinical Evaluation

Preclinical evaluation of the PARP-inhibitor olaparib for the treatment of ovarian clear cell cancer

2011 ◽  
Vol 71 (08) ◽  
Author(s):  
KJ Dedes ◽  
P Wilkerson ◽  
D Wetterskog ◽  
MB Lambros ◽  
R Natrajan ◽  
...  
Keyword(s):  
Clear Cell ◽  
Parp Inhibitor ◽  
Cell Cancer ◽  
Preclinical Evaluation

Optical imaging probes and their potential contribution to radiotracer development

2016 ◽  
Vol 55 (02) ◽  
pp. 51-62 ◽  
Author(s):  
S. Hermann ◽  
M. Schäfers ◽  
C. Höltke ◽  
A. Faust
Keyword(s):  
Optical Imaging ◽  
Fluorescent Dyes ◽  
Great Influence ◽  
Potential Contribution ◽  
Preclinical Evaluation ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Imaging Probes ◽  
Unspecific Binding

SummaryOptical imaging has long been considered a method for histological or microscopic investigations. Over the last 15 years, however, this method was applied for preclinical molecular imaging and, just recently, was also able to show its principal potential for clinical applications (e.g. fluorescence-guided surgery). Reviewing the development and preclinical evaluation of new fluorescent dyes and target-specific dye conjugates, these often show characteristic patterns of their routes of excretion and biodistribution, which could also be interesting for the development and optimization of radiopharmaceuticals. Especially ionic charges show a great influence on biodistribution and netcharge and charge-distribution on a conjugate often determines unspecific binding or background signals in liver, kidney or intestine, and other organs.Learning from fluorescent probe behaviour in vivo and translating this knowledge to radio-pharmaceuticals might be useful to further optimize emerging and existing radiopharmaceuticals with respect to their biodistribution and thereby availability for binding to their targets.

Preclinical evaluation of F-18-PSMA PET in glioblastoma as a potential theranostic approach

2020 ◽  
Author(s):  
M Kirchner ◽  
A Holzgreve ◽  
M Brendel ◽  
V Ruf ◽  
D Pötter ◽  
...  
Keyword(s):  
Preclinical Evaluation ◽  
Psma Pet

Synthesis and Preclinical Evaluation of Ga-68-labeled Adnectin as a PET Agent for Imaging PD-L1 Expression

2020 ◽  
Author(s):  
S Robu ◽  
A Richter ◽  
D Gosmann ◽  
C Seidl ◽  
D Leung ◽  
...  
Keyword(s):  
Preclinical Evaluation

Topical Therapy of Alopecia with Squaric Acid Dibutylester.

1994 ◽  
Vol 56 (1) ◽  
pp. 105-108 ◽  
Author(s):  
Hiroshi HACHISUKA ◽  
Osamu MORI ◽  
Tomoyuki MAEDA ◽  
Yoichiro SASAI
Keyword(s):  
Topical Therapy ◽  
Squaric Acid
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