scholarly journals Rationally Designed Polypharmacology: α‐Helix Mimetics as Dual Inhibitors of the Oncoproteins Mcl‐1 and HDM2

ChemMedChem ◽  
2020 ◽  
Vol 15 (18) ◽  
pp. 1691-1698 ◽  
Author(s):  
Ivie L. Conlon ◽  
Brandon Drennen ◽  
Maryanna E. Lanning ◽  
Samuel Hughes ◽  
Rebecca Rothhaas ◽  
...  
Keyword(s):  
Dual Inhibitors ◽  
Helix Mimetics ◽  
Α Helix

Synthesis of Pyridazine-Based Scaffolds as α-Helix Mimetics

2007 ◽  
Vol 9 (19) ◽  
pp. 3733-3736 ◽  
Author(s):  
Alessandro Volonterio ◽  
Lionel Moisan ◽  
Julius Rebek
Keyword(s):  
Helix Mimetics ◽  
Α Helix

Expedient route to functionalized and water soluble 5-6-5 imidazole-phenyl-thiazole based α-helix mimetics

Tetrahedron ◽  
2013 ◽  
Vol 69 (5) ◽  
pp. 1663-1668 ◽  
Author(s):  
Christopher G. Cummings ◽  
Andrew D. Hamilton
Keyword(s):  
Water Soluble ◽  
Helix Mimetics ◽  
Α Helix

scholarly journals Design, Synthesis, and Conformational Analysis of Oligobenzanilides as Multifacial α-Helix Mimetics

2019 ◽  
Vol 21 (12) ◽  
pp. 4433-4438 ◽  
Author(s):  
Theo Flack ◽  
Charles Romain ◽  
Andrew J. P. White ◽  
Peter R. Haycock ◽  
Anna Barnard
Keyword(s):  
Conformational Analysis ◽  
Design Synthesis ◽  
Helix Mimetics ◽  
Α Helix

Synthesis of α-helix mimetics with four side-chains

2008 ◽  
Vol 18 (22) ◽  
pp. 5909-5911 ◽  
Author(s):  
Per Restorp ◽  
Julius Rebek
Keyword(s):  
Side Chains ◽  
Helix Mimetics ◽  
Α Helix

scholarly journals Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

2009 ◽  
Vol 49 (4) ◽  
pp. 736-739 ◽  
Author(s):  
Ishu Saraogi ◽  
James A. Hebda ◽  
Jorge Becerril ◽  
Lara A. Estroff ◽  
Andrew D. Miranker ◽  
...  
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Islet Amyloid ◽  
Helix Mimetics ◽  
Α Helix

scholarly journals Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold

2015 ◽  
Vol 13 (32) ◽  
pp. 8642-8646 ◽  
Author(s):  
M. E. Lanning ◽  
P. T. Wilder ◽  
H. Bailey ◽  
B. Drennen ◽  
M. Cavalier ◽  
...  
Keyword(s):  
Helix Mimetics ◽  
Α Helix ◽  
Key Residues

Key residues on opposing faces of the Bak-BH3 α-helix were recapitulated by the 2,6,9-tri-substitution of a purine scaffold.

scholarly journals In silico exploration of small-molecule α-helix mimetics as inhibitors of SARS-COV-2 attachment to ACE2

2020 ◽  
pp. 1-12
Author(s):  
Mohammed Hakmi ◽  
E L Mehdi Bouricha ◽  
Jihane Akachar ◽  
Badreddine Lmimouni ◽  
Jaouad El Harti ◽  
...  
Keyword(s):  
Small Molecule ◽  
In Silico ◽  
Helix Mimetics ◽  
Α Helix

scholarly journals Design and Synthesis of Oligoamide-Based Double α-Helix Mimetics

2013 ◽  
Vol 2013 (17) ◽  
pp. 3433-3445 ◽  
Author(s):  
Oleg V. Kulikov ◽  
Sam Thompson ◽  
Hai Xu ◽  
Christopher D. Incarvito ◽  
Richard T. W. Scott ◽  
...  
Keyword(s):  
Design And Synthesis ◽  
Helix Mimetics ◽  
Α Helix

Controlling Curvature in a Family of Oligoamide α-Helix Mimetics

2008 ◽  
Vol 47 (50) ◽  
pp. 9691-9694 ◽  
Author(s):  
Ishu Saraogi ◽  
Christopher D. Incarvito ◽  
Andrew D. Hamilton
Keyword(s):  
Helix Mimetics ◽  
Α Helix
Sign in / Sign up

Export Citation Format

Share Document