Differentiation of glial cells and motor neurons during the formation of neuromuscular junctions in cocultures of rat spinal cord explant and human muscle

2001 ◽  
Vol 438 (2) ◽  
pp. 239-251 ◽  
Author(s):  
Tomaz Mars ◽  
Kevin J. Yu ◽  
Xue-Ming Tang ◽  
Armand F. Miranda ◽  
Zoran Grubic ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Glial Cells ◽  
Motor Neurons ◽  
Neuromuscular Junctions ◽  
Human Muscle ◽  
Rat Spinal Cord

scholarly journals Radial glial cells derived from the neonatal rat spinal cord: morphological and immunocytochemical characterization

2005 ◽  
Vol 68 (5) ◽  
pp. 361-369 ◽  
Author(s):  
Marjan Moreels ◽  
Frank Vandenabeele ◽  
Leen Deryck ◽  
Ivo Lambrichts
Keyword(s):  
Spinal Cord ◽  
Glial Cells ◽  
Neonatal Rat ◽  
Rat Spinal Cord ◽  
Radial Glial Cells ◽  
Radial Glial

Histoenzymatic profile of human muscle cultured in monolayer and innervated de novo by fetal rat spinal cord

1988 ◽  
Vol 11 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Giuseppe Vita ◽  
Valerie Askanas ◽  
Andrea Martinuzzi ◽  
W. King Engel
Keyword(s):  
Spinal Cord ◽  
De Novo ◽  
Human Muscle ◽  
Rat Spinal Cord ◽  
Fetal Rat

Neurotrophins increase motoneurons' ability to innervate skeletal muscle fibers in rat spinal cord-human muscle cocultures

1996 ◽  
Vol 136 (1-2) ◽  
pp. 17-23 ◽  
Author(s):  
Serge Braun ◽  
Bernard Croizat ◽  
Marie-Claude Lagrange ◽  
Jean-Marie Warter ◽  
Philippe Poindron
Keyword(s):  
Skeletal Muscle ◽  
Spinal Cord ◽  
Muscle Fibers ◽  
Human Muscle ◽  
Rat Spinal Cord ◽  
Skeletal Muscle Fibers

An optimized method for obtaining adult rat spinal cord motor neurons to be used for tissue culture

2016 ◽  
Vol 273 ◽  
pp. 128-137
Author(s):  
Malcolm Brinn ◽  
Katie O’Neill ◽  
Ian Musgrave ◽  
Brian J.C. Freeman ◽  
Maciej Henneberg ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Tissue Culture ◽  
Motor Neurons ◽  
Rat Spinal Cord ◽  
Adult Rat ◽  
Adult Rat Spinal Cord

scholarly journals Regeneration of spinal motor axons: Negative regulation by Celsr2 implicating Cdc42/Rac1 and JNK/c-Jun signaling

2021 ◽  
Author(s):  
Quan Wen ◽  
Huandi Weng ◽  
Tao Liu ◽  
Lingtai Yu ◽  
Tainyun Zhao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Motor Neurons ◽  
Axon Regeneration ◽  
Neuromuscular Junctions ◽  
Motor Axon ◽  
Neural Repair ◽  
Human Spinal Cord ◽  
Spinal Motor ◽  
Motor Neuron Survival ◽  
Injury Model

AbstractDuring development, cadherins Celsr2 and Celsr3 control axon navigation. Unlike Celsr3, Celsr2 remains expressed in the adult, suggesting unexplored roles in maintenance and repair. Here we show that Celsr2 knockdown promotes motor axon regeneration in mouse and human spinal cord explants and cultured motor neurons. Celsr2 downregulation is accompanied by increased levels of GTP-bound Rac1 and Cdc42, and of JNK and c-Jun proteins. Using a branchial plexus injury model, we show that forelimb functional recovery is improved in Celsr2 mutant versus control mice. Compared to controls, in mutant mice, reinnervated biceps muscles are less atrophic, contain more newly formed neuromuscular junctions, and generate larger electromyographic potentials, while motor neuron survival and axon regeneration are improved. GTP-bound Rac1 and Cdc42, JNK and c-Jun are upregulated in injured mutant versus control spinal cord. In conclusion, Celsr2 negatively regulates motor axon regeneration via Cdc42/Rac1/JNK/c-Jun signaling and is a target for neural repair.

Developmental study of the expression of dystrophin in cultured human muscle aneurally and innervated with fetal rat spinal cord

1991 ◽  
Vol 565 (2) ◽  
pp. 280-289 ◽  
Author(s):  
Yong Choo Park-Matsumoto ◽  
Noriyoshi Kameda ◽  
Takayoshi Kobayashi ◽  
Hiroshi Tsukagoshi
Keyword(s):  
Spinal Cord ◽  
Human Muscle ◽  
Developmental Study ◽  
Rat Spinal Cord ◽  
Fetal Rat
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