Gas chromatography-mass spectrometry of nortriptyline in body fluids of man

1971 ◽  
Vol 12 (3) ◽  
pp. 496-505 ◽  
Author(s):  
Carl-Gustaf Hammar ◽  
Balzar Alexanderson ◽  
Bo Holmstedt ◽  
Folke Sjôqvist
1995 ◽  
Vol 307 (2) ◽  
pp. 331-333 ◽  
Author(s):  
T Kumazawa ◽  
K Sato ◽  
H Seno ◽  
A Ishii ◽  
O Suzuki

The levels of free pyrroloquinoline quinone (PQQ) in various foods were examined by the use of gas chromatography-mass spectrometry. PQQ was extracted from the samples, after addition of [U-13C]PQQ as internal standard, with n-butanol and Sep-Pak C18 cartridges. After derivatization of PQQ with phenyltrimethylammonium hydroxide, molecular peaks at m/z 448 and 462 were used for detection of PQQ and [U-13C]PQQ respectively, by selected ion monitoring. Free PQQ could be detected in every sample in the range 3.7-61 ng/g or ng/ml. Since its levels in human tissues and body fluids are 5-10 times lower than those found in foods, it is probable that PQQ existing in human tissues is derived, at least partly, from the diet.


1986 ◽  
Vol 35 (3) ◽  
pp. 293-297
Author(s):  
Tomiharu ITO ◽  
Masahiro ABE ◽  
Fumihiko IMAMURA ◽  
Yasuhiko MATSUKI ◽  
Toshio NAMBARA

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