The neural correlates of trauma‐related autobiographical memory in posttraumatic stress disorder: A meta‐analysis

2019 ◽  
Vol 37 (4) ◽  
pp. 321-345 ◽  
Author(s):  
Janine Thome ◽  
Braeden A. Terpou ◽  
Margaret C. McKinnon ◽  
Ruth A. Lanius
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Autobiographical Memory ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Meta Analysis ◽  
Neural Correlates

Neural signatures of conditioning, extinction learning, and extinction recall in posttraumatic stress disorder: a meta-analysis of functional magnetic resonance imaging studies

2019 ◽  
Vol 50 (9) ◽  
pp. 1442-1451 ◽  
Author(s):  
Benjamin Suarez-Jimenez ◽  
Anton Albajes-Eizagirre ◽  
Amit Lazarov ◽  
Xi Zhu ◽  
Ben J. Harrison ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Meta Analysis ◽  
Neural Correlates ◽  
Extinction Learning ◽  
Treatment Development ◽  
Novel Treatment ◽  
Conditioning Extinction ◽  
Neural Signatures

AbstractBackgroundEstablishing neurobiological markers of posttraumatic stress disorder (PTSD) is essential to aid in diagnosis and treatment development. Fear processing deficits are central to PTSD, and their neural signatures may be used as such markers.MethodsHere, we conducted a meta-analysis of seven Pavlovian fear conditioning fMRI studies comparing 156 patients with PTSD and 148 trauma-exposed healthy controls (TEHC) using seed-basedd-mapping, to contrast neural correlates of experimental phases, namely conditioning, extinction learning, and extinction recall.ResultsPatients with PTSD, as compared to TEHCs, exhibited increased activation in the anterior hippocampus (extending to the amygdala) and medial prefrontal cortex during conditioning; in the anterior hippocampus-amygdala regions during extinction learning; and in the anterior hippocampus-amygdala and medial prefrontal areas during extinction recall. Yet, patients with PTSD have shown an overall decreased activation in the thalamus during all phases in this meta-analysis.ConclusionFindings from this metanalysis suggest that PTSD is characterized by increased activation in areas related to salience and threat, and lower activation in the thalamus, a key relay hub between subcortical areas. If replicated, these fear network alterations may serve as objective diagnostic markers for PTSD, and potential targets for novel treatment development, including pharmacological and brain stimulation interventions. Future longitudinal studies are needed to examine whether these observed network alteration in PTSD are the cause or the consequence of PTSD.

Delayed Posttraumatic Stress Disorder: Systematic Review, Meta-Analysis, and Metaregression

2009 ◽  
Author(s):  
Geert Smid ◽  
Trudy Mooren ◽  
Roos Van der Mast ◽  
Berthold Gersens ◽  
Rolf Kleber
Keyword(s):  
Systematic Review ◽  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Meta Analysis

Meta-analysis links posttraumatic stress disorder to intimate partner problems

2011 ◽  
Author(s):  
C. T. Taft ◽  
L. E. Watkins ◽  
J. Stafford ◽  
A. E. Street ◽  
C. M. Monson
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Meta Analysis ◽  
Intimate Partner

Shame on the brain: Neural correlates of moral injury event recall in posttraumatic stress disorder

2020 ◽  
Author(s):  
Chantelle S. Lloyd ◽  
Andrew A. Nicholson ◽  
Maria Densmore ◽  
Jean Théberge ◽  
Richard W. J. Neufeld ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Neural Correlates ◽  
Moral Injury ◽  
Injury Event ◽  
Event Recall ◽  
The Brain

scholarly journals Impaired Autobiographical Memory Flexibility in Iranian Trauma Survivors With Posttraumatic Stress Disorder

2021 ◽  
Vol 9 (2) ◽  
pp. 294-301 ◽  
Author(s):  
Maryam Piltan ◽  
Ali Reza Moradi ◽  
Mohammad Hassan Choobin ◽  
Parviz Azadfallah ◽  
Sara Eskandari ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Autobiographical Memory ◽  
Posttraumatic Stress ◽  
Emotional Disturbance ◽  
Stress Disorder ◽  
Small Sample ◽  
Trauma Survivors ◽  
Community Control ◽  
Memory Specificity ◽  
Memory Flexibility

Reduced ability to retrieve specific autobiographical memories is a well-defined feature of posttraumatic stress disorder (PTSD), and science-driven interventions have emerged to improve memory specificity and thereby symptoms. However, research in depressed samples indicates that the ability to flexibly move between retrieval of specific and general memory types (i.e., memory flexibility) may more accurately conceptualize autobiographical memory deficits in emotional disturbance. In this study, we evaluated memory specificity and memory flexibility in Iranian trauma survivors ( N = 63) with and without PTSD relative to community control participants. Trauma-exposed participants had experienced a serious road-traffic accident. Results indicated that individuals with PTSD experienced reduced memory specificity and memory flexibility relative to trauma-exposed participants and community control participants. A small sample size limits the strength of conclusions, although good statistical power was obtained. Findings suggest that reduced memory flexibility may be a transdiagnostic marker of emotional disturbance and support further development of memory flexibility interventions for PTSD.

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