GABA-A agonists and GABA uptake inhibitors: Structure-activity relationships

Drug Development Research ◽

10.1002/ddr.430210304 ◽

1990 ◽

Vol 21 (3) ◽

pp. 169-188 ◽

Author(s):

Erik Falch ◽

Orla M. Larsson ◽

Arne Schousboe ◽

Povl Krogsgaard-Larsen

Keyword(s):

Gaba Uptake ◽

Gaba A ◽

Structure Activity Relationships ◽

Structure Activity ◽

Uptake Inhibitors ◽

Gaba Uptake Inhibitors

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Structure-Activity Relationships of Selective GABA Uptake Inhibitors

Current Topics in Medicinal Chemistry ◽

10.2174/156802606778249801 ◽

2006 ◽

Vol 6 (17) ◽

pp. 1861-1882 ◽

Author(s):

Signe Hog ◽

Jeremy Greenwood ◽

Karsten Madsen ◽

Orla Larsson ◽

Bente Frolund ◽

...

Keyword(s):

Gaba Uptake ◽

Structure Activity Relationships ◽

Structure Activity ◽

Uptake Inhibitors ◽

Gaba Uptake Inhibitors

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GABA uptake inhibitors. Syntheses and structure—activity studies on GABA analogues containing diarylbutenyl and diarylmethoxyalkyl N-substituents

European Journal of Medicinal Chemistry ◽

10.1016/0223-5234(91)90214-8 ◽

1991 ◽

Vol 26 (1) ◽

pp. 69-77 ◽

Author(s):

E Falch ◽

P Korgsgaard-Larsen

Keyword(s):

Gaba Uptake ◽

Structure Activity ◽

Uptake Inhibitors ◽

Gaba Analogues ◽

Gaba Uptake Inhibitors

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The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (Tiagabine) as an anticonvulsant drug candidate

Journal of Medicinal Chemistry ◽

10.1021/jm00064a005 ◽

1993 ◽

Vol 36 (12) ◽

pp. 1716-1725 ◽

Author(s):

Knud Erik Andersen ◽

Claus Braestrup ◽

Frederik C. Groenwald ◽

Anker S. Joergensen ◽

Erik B. Nielsen ◽

...

Keyword(s):

Anticonvulsant Drug ◽

Drug Candidate ◽

Gaba Uptake ◽

Structure Activity ◽

Uptake Inhibitors ◽

Gaba Uptake Inhibitors

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Synthesis, biological evaluation and structure–activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.06.024 ◽

2014 ◽

Vol 83 ◽

pp. 256-273 ◽

Author(s):

Paula Kowalczyk ◽

Kinga Sałat ◽

Georg C. Höfner ◽

Marta Mucha ◽

Anna Rapacz ◽

...

Keyword(s):

Structure Activity Relationship ◽

Biological Evaluation ◽

Activity Relationship ◽

Gaba Uptake ◽

Structure Activity ◽

Uptake Inhibitors ◽

Relationship Of ◽

Derivatives Of ◽

Gaba Uptake Inhibitors

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Synthesis of Novel γ-Aminobutyric Acid (GABA) Uptake Inhibitors. 5.1Preparation and Structure−Activity Studies of Tricyclic Analogues of Known GABA Uptake Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm990513k ◽

2001 ◽

Vol 44 (13) ◽

pp. 2152-2163 ◽

Author(s):

Knud Erik Andersen ◽

Jan L. Sørensen ◽

Jesper Lau ◽

Behrend F. Lundt ◽

Hans Petersen ◽

...

Keyword(s):

Aminobutyric Acid ◽

Gaba Uptake ◽

Structure Activity ◽

Uptake Inhibitors ◽

Gaba Uptake Inhibitors

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ChemInform Abstract: Synthesis of Novel γ-Aminobutyric Acid (GABA) Uptake Inhibitors. Part 5. Preparation and Structure-Activity Studies of Tricyclic Analogues of Known GABA Uptake Inhibitors.

10.1002/chin.200141187 ◽

2010 ◽

Vol 32 (41) ◽

pp. no-no

Author(s):

Knud Erik Andersen ◽

Jan L. Soerensen ◽

Jesper Lau ◽

Behrend F. Lundt ◽

Hans Petersen ◽

...

Keyword(s):

Aminobutyric Acid ◽

Gaba Uptake ◽

Structure Activity ◽

Uptake Inhibitors ◽

Gaba Uptake Inhibitors

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The Role of Structure Activity Relationship Studies in the Search for New GABA Uptake Inhibitors

Mini-Reviews in Medicinal Chemistry ◽

10.2174/138955708786141070 ◽

2008 ◽

Vol 8 (12) ◽

pp. 1214-1223 ◽

Author(s):

Katarzyna Kulig ◽

Marta Szwaczkiewicz

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Gaba Uptake ◽

Structure Activity ◽

Uptake Inhibitors ◽

Gaba Uptake Inhibitors

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Structure activity relationship of selective GABA uptake inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.03.060 ◽

2015 ◽

Vol 23 (10) ◽

pp. 2480-2488 ◽

Author(s):

Stine B. Vogensen ◽

Lars Jørgensen ◽

Karsten K. Madsen ◽

Andreas Jurik ◽

Nrupa Borkar ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Gaba Uptake ◽

Structure Activity ◽

Uptake Inhibitors ◽

Relationship Of ◽

Gaba Uptake Inhibitors

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Synthesis and Biochemical Studies of Spirocyclic Amino Acid Esters, Part 3 Activity of 2-Azaspiro[4.5]decane-6-carboxylates as GABA-Uptake Inhibitors

Archiv der Pharmazie ◽

10.1002/ardp.19963290307 ◽

1996 ◽

Vol 329 (3) ◽

pp. 149-154 ◽

Author(s):

Wilhelm Fleischhacker ◽

Silvia Lauritz ◽

Ernst Urban ◽

Peter Baumann ◽

Helmut Bittiger

Keyword(s):

Gaba Uptake ◽

Amino Acid Esters ◽

Uptake Inhibitors ◽

Biochemical Studies ◽

Gaba Uptake Inhibitors ◽

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ChemInform Abstract: Design, Synthesis and Evaluation of Substituted Triarylnipecotic Acid Derivatives as GABA Uptake Inhibitors: Identification of a Ligand with Moderate Affinity and Selectivity for the Cloned Human GABA Transporter GAT-3.

10.1002/chin.199451176 ◽

2010 ◽

Vol 25 (51) ◽

pp. no-no

Author(s):

T. G. M. DHAR ◽

L. A. BORDEN ◽

S. TYAGARAJAN ◽

K. E. SMITH ◽

T. A. BRANCHEK ◽

...

Keyword(s):

Gaba Uptake ◽

Gaba Transporter ◽

Design Synthesis ◽

Uptake Inhibitors ◽

Gaba Uptake Inhibitors

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