Limitations in the use of tubulin polymerization assays as a screen for the identification of new antimitotic agents: The potent marine natural product curacin A as an example

1995 ◽  
Vol 34 (2) ◽  
pp. 110-120 ◽  
Author(s):  
Ernest Hamel ◽  
Andrei V. Blokhin ◽  
Dale G. Nagle ◽  
Hye-Dong Yoo ◽  
William H. Gerwick
Keyword(s):  
Natural Product ◽  
Marine Natural Product ◽  
Tubulin Polymerization ◽  
Curacin A

Synthesis and Biological Evaluation of a Focused Mixture Library of Analogues of the Antimitotic Marine Natural Product Curacin A

2000 ◽  
Vol 122 (39) ◽  
pp. 9391-9395 ◽  
Author(s):  
Peter Wipf ◽  
Jonathan T. Reeves ◽  
Raghavan Balachandran ◽  
Kenneth A. Giuliano ◽  
Ernest Hamel ◽  
...  
Keyword(s):  
Natural Product ◽  
Biological Evaluation ◽  
Marine Natural Product ◽  
Curacin A ◽  
Synthesis And Biological Evaluation

Progress Toward The Total Synthesis Of The Marine Natural Product Karlotoxin 5

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
M Albadry ◽  
Y Zou ◽  
Y Takahashi ◽  
A Waters ◽  
M Hossein ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Marine Natural Product

Actin-binding Comparisons of the Marine Natural Product Latrunculin B with Natural and Semi-synthetic Latrunculin B Analogs

Planta Medica ◽  
2008 ◽  
Vol 74 (03) ◽  
Author(s):  
JJ Bowling ◽  
PR Daga ◽  
S Odde ◽  
SA Ahmed ◽  
MK Mesbah ◽  
...  
Keyword(s):  
Natural Product ◽  
Marine Natural Product ◽  
Actin Binding ◽  
Latrunculin B

Synthesis and antibacterial activities of marine natural product Ianthelliformisamines and subereamine synthetic analogues

2021 ◽  
pp. 127883
Author(s):  
Shivaji Narayan Khadake ◽  
Shaik Karamathulla ◽  
Tapan Kumar Jena ◽  
Mohan Monisha ◽  
Nikhil Kumar Tuti ◽  
...  
Keyword(s):  
Natural Product ◽  
Antibacterial Activities ◽  
Marine Natural Product ◽  
Synthetic Analogues

Chirality Transfer from a Chiral Primary Alcohol Equivalent Through Allyl Cyanate-to-Isocyanate Rearrangement: Synthesis of (+)-Geranyllinaloisocyanide

Synthesis ◽  
2019 ◽  
Vol 51 (15) ◽  
pp. 2959-2964 ◽  
Author(s):  
Yoshiyasu Ichikawa ◽  
Hirofumi Morimoto ◽  
Toshiya Masuda
Keyword(s):  
Natural Product ◽  
Primary Alcohol ◽  
Marine Natural Product ◽  
Chirality Transfer ◽  
New Approach ◽  
Stereogenic Centers ◽  
Quaternary Stereogenic Centers

A new approach was developed to construct quaternary stereogenic centers bearing nitrogen substituents in an enantioselective manner. The strategy takes advantage of [1,3]-chirality transfer from a chiral primary alcohol equivalent through an allyl cyanate-to-isocyanate rearrangement. This approach was employed in an efficient eight-step synthesis of the marine natural product, (+)-geranyllinaloisocyanide, in 43% overall yield.

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