Synthesis and Biological Evaluation of a Focused Mixture Library of Analogues of the Antimitotic Marine Natural Product Curacin A

2000 ◽  
Vol 122 (39) ◽  
pp. 9391-9395 ◽  
Author(s):  
Peter Wipf ◽  
Jonathan T. Reeves ◽  
Raghavan Balachandran ◽  
Kenneth A. Giuliano ◽  
Ernest Hamel ◽  
...  
Keyword(s):  
Natural Product ◽  
Biological Evaluation ◽  
Marine Natural Product ◽  
Curacin A ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of the ascidian blood-pigment halocyamine A

2017 ◽  
Vol 15 (29) ◽  
pp. 6194-6204 ◽  
Author(s):  
Hugo K. H. Fong ◽  
Jean Michel Brunel ◽  
Arlette Longeon ◽  
Marie-Lise Bourguet-Kondracki ◽  
David Barker ◽  
...  
Keyword(s):  
Natural Product ◽  
Biological Evaluation ◽  
Marine Natural Product ◽  
Synthesis And Biological Evaluation ◽  
Blood Pigment

The first synthesis of the (Z)-indolic enamide-containing antibacterial marine natural product halocyamine A is reported.

Synthesis and Biological Evaluation of Structurally Highly Modified Analogues of the Antimitotic Natural Product Curacin A

2002 ◽  
Vol 45 (9) ◽  
pp. 1901-1917 ◽  
Author(s):  
Peter Wipf ◽  
Jonathan T. Reeves ◽  
Raghavan Balachandran ◽  
Billy W. Day
Keyword(s):  
Natural Product ◽  
Biological Evaluation ◽  
Curacin A ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

Synthesis and biological evaluation of acylated oligorhamnoside derivatives structurally related to mezzettiaside-6 with cytotoxic activity

2016 ◽  
Vol 14 (28) ◽  
pp. 6691-6702 ◽  
Author(s):  
Gaopeng Song ◽  
Sumei Li ◽  
Zhiwei Lei ◽  
Yibin Li ◽  
Junhua Li ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Natural Product ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Two partially acylated oligorhamnoside derivatives 1 and 2 structurally related to the natural product mezzettiaside-6 were synthesized via a ‘2 + 1 + 1’ convergent strategy.

Sign in / Sign up

Export Citation Format

Share Document