Increase in adenosine A1 receptor gene expression in the liver of streptozotocin-induced diabetic rats

2003 ◽  
Vol 19 (3) ◽  
pp. 209-215 ◽  
Author(s):  
I. M. Liu ◽  
T. F. Tzeng ◽  
C. C. Tsai ◽  
T. Y. Lai ◽  
C. T. Chang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Receptor Gene ◽  
Diabetic Rats ◽  
Adenosine A1 Receptor ◽  
Adenosine A1 ◽  
A1 Receptor ◽  
Receptor Gene Expression

Increase of adenosine A1 receptor gene expression in cerebral ischemia of Wistar rats

2005 ◽  
Vol 387 (2) ◽  
pp. 59-61 ◽  
Author(s):  
Dar-Ming Lai ◽  
Yong-Kwang Tu ◽  
I-Min Liu ◽  
Juei-Tang Cheng
Keyword(s):  
Gene Expression ◽  
Cerebral Ischemia ◽  
Wistar Rats ◽  
Receptor Gene ◽  
Adenosine A1 Receptor ◽  
Adenosine A1 ◽  
A1 Receptor ◽  
Receptor Gene Expression

MYOCARDIAL ADENOSINE A1-RECEPTOR GENE EXPRESSION IS INCREASED IN COMPENSATED PRESSURE-OVERLOAD HYPERTROPHY BUT IS DECREASED IN HEART FAILURE

2000 ◽  
Vol 18 ◽  
pp. S69
Author(s):  
S. Perlini ◽  
B. Arosio ◽  
P. Vandoni ◽  
D. Santambrogio ◽  
N. Gagliano ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Receptor Gene ◽  
Pressure Overload ◽  
Adenosine A1 Receptor ◽  
Adenosine A1 ◽  
A1 Receptor ◽  
Receptor Gene Expression

scholarly journals Effects of Levetiracetam in Acute and Kindling Model of Epilepsy Through Adenosinergic Pathway in Mice: Possible Involvement of Adenosine A1 Receptor

2021 ◽  
Author(s):  
Muhammad Jamal ◽  
Muhammad Azam ◽  
Shabana Usman Simjee
Keyword(s):  
Gene Expression ◽  
Receptor Antagonist ◽  
Adenosine A1 Receptor ◽  
Nucleoside Transporter ◽  
Signaling Systems ◽  
Kindling Model ◽  
Adenosine Receptor Antagonist ◽  
Adenosine A1 ◽  
A1 Receptor ◽  
The Brain

Abstract Objective: The present study aimed to explore the possible levetiracetam mechanisms of action in the adenosine signaling systems using the PTZ-induced acute seizure and the PTZ-induced kindling model of epileptogenesis.Method: In acute model, male mice received caffeine (non-specific adenosine receptor antagonist), or dipropylcyclopentylxanthine (DPCPX) (specific A1 receptor antagonist) prior to levetiracetam. After 30 minutes, a convulsant dose of PTZ (100 mg/kg) was administered to determine whether caffeine or DPCPX have any antagonistic effects on anti-seizure activity of levetiracetam by analyzing the onset of first myoclonic jerk (FMJ), generalized clonic seizures (GCS) and percent mortality.The chronic PTZ-induced kindling model was set to assess the gene expression changes in adenosine A1 receptor, inwardly-rectifying potassium channel (Kir3.2) and equilibrative nucleoside transporter-1 (ENT-1) through RT-qPCR. Data were analyzed using Origin statistical software version 8.5 and represented as Mean ± SEM.Results: In acute study, we found that caffeine (100 mg/kg) and DPCPX (25 mg/kg) reversed the anti-seizures effects of the levetiracetam significantly by reversing the percent protection and shortening the delay in the FMJ and onset of GCS in animals. In kindling model of epileptogenesis, it was found that levetiracetam increased the gene expression of adenosine A1 receptor andKir3.2 in the brain. Furthermore, levetiracetam significantly reduced the gene expression of ENT-1 in the brain that supposed to enhance the extracellular adenosine in the brain.Conclusion: Based on these results, it can be concluded that in addition to its action on SV2A vesicular protein, levetiracetam also prevent epileptogenesis by acting on the adenosine pathway in the CNS.

Relationship between the Level of Hippocampal Leptin Receptor Gene Expression and Learning Performance in Diabetic Rats

2014 ◽  
Vol 122 (10) ◽  
pp. 615-619 ◽  
Author(s):  
C. Demirel ◽  
S. Balcı ◽  
H. Korkmaz ◽  
E. Akarsu
Keyword(s):  
Gene Expression ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Diabetic Rats ◽  
Learning Performance ◽  
Receptor Gene Expression

scholarly journals Enhanced muscarinic M1 receptor gene expression in the corpus striatum of streptozotocin-induced diabetic rats

2009 ◽  
Vol 16 (1) ◽  
pp. 38 ◽  
Author(s):  
G Gireesh ◽  
T Peeyush Kumar ◽  
Jobin Mathew ◽  
CS Paulose
Keyword(s):  
Gene Expression ◽  
Corpus Striatum ◽  
Receptor Gene ◽  
Diabetic Rats ◽  
M1 Receptor ◽  
Receptor Gene Expression

Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats

2008 ◽  
Vol 441 (2) ◽  
pp. 201-204 ◽  
Author(s):  
Liang-Ming Lee ◽  
Cheng Kuei Chang ◽  
Kai-Chun Cheng ◽  
Dai-Huang Kou ◽  
I-Min Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Muscarinic Receptor ◽  
Receptor Gene ◽  
Diabetic Rats ◽  
M2 Muscarinic Receptor ◽  
Receptor Gene Expression ◽  
Type 2 Diabetic

Decreased muscarinic M1 receptor gene expression in the cerebral cortex of streptozotocin-induced diabetic rats and Aegle marmelose leaf extract's therapeutic function

2008 ◽  
Vol 116 (2) ◽  
pp. 296-304 ◽  
Author(s):  
Gangadharan Gireesh ◽  
S. Khan Reas ◽  
Mathew Jobin ◽  
Cheramadathikudiyil Skaria Paulose
Keyword(s):  
Gene Expression ◽  
Cerebral Cortex ◽  
Receptor Gene ◽  
Diabetic Rats ◽  
M1 Receptor ◽  
Therapeutic Function ◽  
Receptor Gene Expression

scholarly journals Association Analysis of the Adenosine A1 Receptor Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis

2011 ◽  
Vol 9 (1) ◽  
pp. 137-142 ◽  
Author(s):  
> Kobayashi ◽  
Hiroshi Ujike ◽  
Nakao Iwata ◽  
Toshiya Inada ◽  
Mitsuhiko Yamada ◽  
...  
Keyword(s):  
Association Analysis ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Adenosine A1 Receptor ◽  
Methamphetamine Dependence ◽  
Adenosine A1 ◽  
A1 Receptor ◽  
Receptor Gene Polymorphisms

Decreased muscarinic M1 receptor gene expression in the hypothalamus, brainstem, and pancreatic islets of streptozotocin-induced diabetic rats

2008 ◽  
Vol 86 (4) ◽  
pp. 947-953 ◽  
Author(s):  
G. Gireesh ◽  
S. Balarama Kaimal ◽  
T. Peeyush Kumar ◽  
C.S. Paulose
Keyword(s):  
Gene Expression ◽  
Pancreatic Islets ◽  
Receptor Gene ◽  
Diabetic Rats ◽  
M1 Receptor ◽  
Receptor Gene Expression
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