scholarly journals Targeted delivery of a vaccine protein to Langerhans cells in the human skin via the C‐type lectin receptor Langerin

2021 ◽  
Author(s):  
Lydia Bellmann ◽  
Helen Strandt ◽  
Claudia Zelle‐Rieser ◽  
Daniela Ortner ◽  
Christoph H. Tripp ◽  
...  
Keyword(s):  
Human Skin ◽  
Targeted Delivery ◽  
Langerhans Cells ◽  
Lectin Receptor

scholarly journals A specific, glycomimetic Langerin ligand for human Langerhans cell targeting

2018 ◽  
Author(s):  
Eike-Christian Wamhoff ◽  
Jessica Schulze ◽  
Lydia Bellmann ◽  
Gunnar Bachem ◽  
Felix F. Fuchsberger ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Human Skin ◽  
Immune Regulation ◽  
Cancer Vaccines ◽  
Langerhans Cells ◽  
Design Strategy ◽  
T Cell Immunity ◽  
Lectin Receptor ◽  
Cell Immunity ◽  
Delivery Platform

AbstractLangerhans cells are a subset of dendritic cells residing in the epidermis of the human skin. As such, they are key mediators of immune regulation and have emerged as prime targets for novel transcutaneous cancer vaccines. Importantly, the induction of protective T cell immunity by these vaccines requires the efficient and specific delivery of both tumor-associated antigens and adjuvants. Langerhans cells uniquely express Langerin (CD207), an endocytic C-type lectin receptor. Here, we report the discovery of a specific, glycomimetic Langerin ligand employing a heparin-inspired design strategy that integrated NMR spectroscopy and molecular docking. The conjugation of these glycomimetics to liposomes enabled the specific and efficient targeting of Langerhans cells in the human skin. This delivery platform provides superior versatility and scalability over antibody-based approaches and thus addresses current limitations of dendritic cell-based immunotherapies.

scholarly journals Differential Distribution of Langerhans Cells in Organ Culture of Human Skin

1982 ◽  
Vol 79 (5) ◽  
pp. 340-345 ◽  
Author(s):  
Craig A. Elmets ◽  
Paul R. Bergstresser ◽  
J. Wayne Streilein
Keyword(s):  
Organ Culture ◽  
Human Skin ◽  
Langerhans Cells ◽  
Differential Distribution

scholarly journals Influenza virus-like particles coated onto microneedles can elicit stimulatory effects on Langerhans cells in human skin

Vaccine ◽  
2010 ◽  
Vol 28 (37) ◽  
pp. 6104-6113 ◽  
Author(s):  
Marc Pearton ◽  
Sang-Moo Kang ◽  
Jae-Min Song ◽  
Yeu-Chun Kim ◽  
Fu-Shi Quan ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Human Skin ◽  
Langerhans Cells ◽  
Virus Like Particles

Characterization of reconstructed human skin containing Langerhans cells to monitor molecular events in skin sensitization

2018 ◽  
Vol 46 ◽  
pp. 77-85 ◽  
Author(s):  
Stephanie Bock ◽  
André Said ◽  
Gerrit Müller ◽  
Monika Schäfer-Korting ◽  
Christian Zoschke ◽  
...  
Keyword(s):  
Human Skin ◽  
Langerhans Cells ◽  
Skin Sensitization ◽  
Molecular Events ◽  
Reconstructed Human Skin

Specificity of monoclonal antibody anti-T-6 for Langerhans' cells in normal human skin

1982 ◽  
Vol 106 (3) ◽  
pp. 287-289 ◽  
Author(s):  
L. DUBERTRET ◽  
O. PICARD ◽  
M. BAGOT ◽  
M. TULLIEZ ◽  
M. FOSSE ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Human Skin ◽  
Langerhans Cells ◽  
Normal Human Skin ◽  
Normal Human

Intradermally administered TLR4 agonist GLA-SE enhances the capacity of human skin DCs to activate T cells and promotes emigration of Langerhans cells

Vaccine ◽  
2012 ◽  
Vol 30 (28) ◽  
pp. 4216-4224 ◽  
Author(s):  
Laura P. Schneider ◽  
Antoinet J. Schoonderwoerd ◽  
Magdalini Moutaftsi ◽  
Randall F. Howard ◽  
Steven G. Reed ◽  
...  
Keyword(s):  
T Cells ◽  
Human Skin ◽  
Langerhans Cells ◽  
Tlr4 Agonist

Quantitative analysis of T6-positive Langerhans cells in human skin cancers

1986 ◽  
Vol 410 (1) ◽  
pp. 57-63 ◽  
Author(s):  
K. Meissner ◽  
M. Haftek ◽  
M. Arlot ◽  
G. Mauduit ◽  
J. Thivolet
Keyword(s):  
Quantitative Analysis ◽  
Human Skin ◽  
Langerhans Cells ◽  
Skin Cancers
Sign in / Sign up

Export Citation Format

Share Document