The Induction of Chromosomal Aberrations by Tetra Antibiotic in Bone Marrow Cells of Rats in Vivo

2004 ◽  
Vol 40 (8) ◽  
pp. 867-870
Author(s):  
T. Çakmak ◽  
M. Topakta ◽  
A. Kayraldiz
Keyword(s):  
Bone Marrow ◽  
Chromosomal Aberrations ◽  
Bone Marrow Cells ◽  
Marrow Cells

scholarly journals Genotoxic action of the sesquiterpene lactone glaucolide B on mammalian cells in vitro and in vivo

1999 ◽  
Vol 22 (3) ◽  
pp. 401-406 ◽  
Author(s):  
Regislaine V. Burim ◽  
Renata Canalle ◽  
João L. Callegari Lopes ◽  
Catarina S. Takahashi
Keyword(s):  
Bone Marrow ◽  
Sesquiterpene Lactone ◽  
Chromosomal Aberrations ◽  
Mammalian Cells ◽  
Culture Medium ◽  
Bone Marrow Cells ◽  
Proliferation Index ◽  
Marrow Cells

Glaucolide B is a sesquiterpene lactone isolated from Vernonia eremophila Mart. (Vernonieae, Asteraceae) and has schistosomicidal, antimicrobial and analgesic activities. This study examined the cytotoxic and clastogenic activities of glaucolide B in human cultured lymphocytes and in bone marrow cells from BALB/c mice. The mitotic index (MI) and chromosomal aberrations were analyzed in both of the above systems, whereas sister chromatid exchanges (SCE) and the proliferation index (PI) were determined only in vitro. In human cultured lymphocytes, glaucolide B concentrations greater than 15 µg/ml of culture medium completely inhibited cell growth. At 4 µg/ml and 8 µg/ml of culture medium, glaucolide B significantly increased the frequency of chromosomal aberrations in lymphocytes and was also cytotoxic at concentrations ³8 µg/ml; there was no increase in the frequency of SCE. Glaucolide B (160-640 mg/kg) did not significantly increase the frequency of chromosomal aberrations in mouse bone marrow cells nor did it affect cell division. Since glaucolide B showed no clastogenic action on mammalian cells in vivo but was cytotoxic and clastogenic in vitro, caution is needed in its medicinal use.

RADIOCYTOGENETIC EFFECTS ON BONE MARROW CELLS OF OPOSSUM IN VIVO

1973 ◽  
Vol 15 (1) ◽  
pp. 123-126 ◽  
Author(s):  
N. Prasad ◽  
S. C. Bushong ◽  
R. S. MacIntyre
Keyword(s):  
Bone Marrow ◽  
Radiation Dose ◽  
Chromosomal Aberrations ◽  
Bone Marrow Cells ◽  
Radiation Sensitivity ◽  
Didelphis Virginiana ◽  
Whole Body ◽  
Marrow Cells

Bone marrow cells of the opossum (Didelphis virginiana) were examined 24 hr following a whole-body 60Co radiation dose of 100, 300, 500 and 700 rads. Analysis of the number of chromosomes and the chromosomal aberrations resulted in a radiation sensitivity of 0.000605 aberrations/cell/rad and 0.59 × 10−6 aberrations/cell/rad2 for single-hit and multihit type damage respectively.

In vivo chromosomal aberrations in bone marrow cells of rats treated with Marshal

1996 ◽  
Vol 371 (3-4) ◽  
pp. 259-264 ◽  
Author(s):  
Mehmet Topaktaş ◽  
Eyyüp Rencüzoǧullari ◽  
Hasan Basri Idotla
Keyword(s):  
Bone Marrow ◽  
Chromosomal Aberrations ◽  
Bone Marrow Cells ◽  
Marrow Cells
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