Nomogram for selecting thyroid nodules for ultrasound-guided fine-needle aspiration biopsy based on a quantification of risk of malignancy

ABSTRACT Aim To correlate selected clinical and ultrasonographic (US) characteristics with the final histopathological diagnosis in patients with atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS), and whether this information can be used in planning the surgical approach. Materials and methods It is a retrospective study including the operated cases of AUS/FLUS from 2011 to 2014 treated at one center. Results This cohort included 87 women and 28 men. To test for independence between categorical variables, the chi-square test was used. There was no significant correlation between age or US variables and final pathological diagnosis. However, final diagnosis of malignancy was higher in men compared with women (64.3 and 41.4% respectively; p = 0.035). Furthermore, a significant association between the diagnosis of repeated fine needle aspiration biopsy (FNAB) and the final pathological diagnosis was noted (benign vs malignant, p = 0.005). Conclusion The FNAB has a significant role in the assessment of thyroid nodules. Our results showed no correlation between age, US variables, and the risk of malignancy. Male gender is associated with higher risk of malignancy. Clinical significance Determining the risk of malignancy and prediction of surgical outcome may help triaging cases for repeat FNA or proceeding to surgery. How to cite this article Alqahtani S, Alsobhi S, Alsalloum RI, Najjar SN, Al-Hindi HN. Surgical Outcome of Thyroid Nodules with Atypia of Undetermined Significance and Follicular Lesion of Undetermined Significance in Fine Needle Aspiration Biopsy. World J Endoc Surg 2017;9(3):100-103.

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Comparison of Palpation-Guided Fine-Needle Aspiration Biopsy to Ultrasound-Guided Fine-Needle Aspiration Biopsy in the Evaluation of Thyroid Nodules

Thyroid ◽

10.1089/thy.2006.16.555 ◽

2006 ◽

Vol 16 (6) ◽

pp. 555-561 ◽

Cited By ~ 74

Author(s):

Mustafa Cesur ◽

Demet Corapcioglu ◽

Safak Bulut ◽

Alptekin Gursoy ◽

Arif Ender Yilmaz ◽

...

Keyword(s):

Fine Needle Aspiration ◽

Thyroid Nodules ◽

Fine Needle Aspiration Biopsy ◽

Needle Aspiration ◽

Aspiration Biopsy ◽

Ultrasound Guided ◽

Fine Needle ◽

Needle Aspiration Biopsy

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Experience of the Implementation of Rapid On-Site Evaluation in Ultrasound-Guided Fine-Needle Aspiration Biopsy of Thyroid Nodules

Current Problems in Diagnostic Radiology ◽

10.1067/j.cpradiol.2017.06.009 ◽

2018 ◽

Vol 47 (4) ◽

pp. 220-224 ◽

Cited By ~ 2

Author(s):

Flor Marina Medina Chamorro ◽

José Abella Calle ◽

Juliana Escobar Stein ◽

Lina Merchancano ◽

Andrés Mauricio Mendoza Briñez ◽

...

Keyword(s):

Fine Needle Aspiration ◽

Thyroid Nodules ◽

Fine Needle Aspiration Biopsy ◽

Needle Aspiration ◽

Aspiration Biopsy ◽

Ultrasound Guided ◽

Fine Needle ◽

Site Evaluation ◽

Needle Aspiration Biopsy

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Clinical relevance of non-palpable thyroid nodules as assessed by ultrasound-guided fine needle aspiration biopsy

Journal of Endocrinological Investigation ◽

10.1007/bf03345124 ◽

2003 ◽

Vol 26 (1) ◽

pp. 61-64 ◽

Cited By ~ 15

Author(s):

D. Nabriski ◽

R. Ness-Abramof ◽

T. Brosh ◽

O. Konen ◽

M. S. Shapiro ◽

...

Keyword(s):

Fine Needle Aspiration ◽

Clinical Relevance ◽

Thyroid Nodules ◽

Fine Needle Aspiration Biopsy ◽

Needle Aspiration ◽

Aspiration Biopsy ◽

Ultrasound Guided ◽

Fine Needle ◽

Needle Aspiration Biopsy

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The frequency of malignant disease in cytological group of suspected cancer (ultrasound-guided fine-needle aspiration biopsy of nonpalpable thyroid nodules)

Medicina ◽

10.3390/medicina44030024 ◽

2008 ◽

Vol 44 (3) ◽

pp. 189

Author(s):

Edita Mišeikytė-Kaubrienė ◽

Albertas Ulys ◽

Mantas Trakymas

Keyword(s):

Fine Needle Aspiration ◽

Thyroid Nodules ◽

Fine Needle Aspiration Biopsy ◽

Needle Aspiration ◽

Aspiration Biopsy ◽

Ultrasound Guided ◽

Fine Needle ◽

Cytological Features ◽

Malignant Lesions ◽

Needle Aspiration Biopsy

Background. Fine-needle aspiration biopsy is the most important procedure for differentiating benign thyroid nodules from malignant ones. Traditionally, findings of fine-needle aspiration biopsy are divided into four categories: nondiagnostic, benign lesions, suspected cancer, and malignant lesions. Group suspicious for cancer largely involves follicular neoplasms as well as lesions with cytological features of malignancy. Objective. The purpose of this study was to establish the value of ultrasound-guided fine-needle aspiration biopsy in the diagnosis of nonpalpable thyroid cancer and to assess the frequency of malignant disease in the group of suspected cancer. Patients and methods. A total of 184 patients with nonpalpable thyroid nodules (less than 1.5 cm in diameter) were examined by means of ultrasound-guided fine-needle aspiration biopsy. Patients were included in the study based on sonographic findings implicating possible malignant nature of nodules. Results. During 1997–2002, 204 ultrasound-guided fine-needle aspiration biopsies of thyroid nodules were performed; findings were nondiagnostic in 5.9% of cases. In 59.8% of cases, cytological examination revealed benign lesions; in 11.8%, suspected cancer; and in 22.5%, malignant lesions. Eighty-five patients underwent subsequent surgery with histological examination of specimens obtained. In 45 cases, cytological diagnosis of malignant or suspected thyroid cancer was confirmed by histological examination after surgery. Conclusion. We conclude that ultrasound-guided fine-needle aspiration biopsy has a high accuracy in the diagnostic evaluation of nonpalpable thyroid nodule with cytological features of malignancy. However, fineneedle aspiration biopsy is not effective diagnostic method for differentiating benign thyroid nodules from malignant ones in follicular neoplasm group.

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