Utility of intraoperative digital scintigraphy in radioguided parathyroidectomy

Head & Neck ◽  
2021 ◽  
Author(s):  
Erin Weatherford Creighton ◽  
Quinn Dunlap ◽  
Merry M. Peckham ◽  
Christopher Elms ◽  
Deanne King ◽  
...  
Keyword(s):  
Radioguided Parathyroidectomy

Ex Vivo Radioactive Counts and Decay Rates of Tissues Resected During Radioguided Parathyroidectomy

2006 ◽  
Vol 136 (2) ◽  
pp. 187-191 ◽  
Author(s):  
Jordan Olson ◽  
Dan Repplinger ◽  
Jesus Bianco ◽  
Herbert Chen
Keyword(s):  
Ex Vivo ◽  
Decay Rates ◽  
Radioguided Parathyroidectomy

scholarly journals Radioguided Parathyroidectomy with Portable Mini Gamma-Camera for the Treatment of Primary Hyperparathyroidism

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Claudio Casella ◽  
Pierluigi Rossini ◽  
Carlo Cappelli ◽  
Chiara Nessi ◽  
Riccardo Nascimbeni ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Diagnostic Accuracy ◽  
Gamma Camera ◽  
Parathyroid Glands ◽  
Minimally Invasive Approach ◽  
Invasive Approach ◽  
Neck Ultrasound ◽  
Radioguided Parathyroidectomy ◽  
Correct Location ◽  
Preoperative Localisation

Background. A proper localisation of pathological parathyroid glands is essential for a minimally invasive approach in the surgical treatment of primary hyperparathyroidism (PHP). The recent introduction of portable mini gamma-cameras (pMGCs) enabled intraoperative scintigraphic scanning. The aim of our study is to evaluate the efficacy of this new method and compare it with the preoperative localisation surveys.Methods. 20 patients were studied; they were evaluated preoperatively by neck ultrasound andTc-sestaMIBI-scintigraphy and intraoperatively with the pMGC IP Guardian 2. The results obtained from the three evaluations were compared.Results. The pMGC presented a sensitivity of 95%, a specificity of 98.89%, and a diagnostic accuracy of 98.18%, which were higher than those of preoperative ultrasound (sensitivity 55%; specificity 95%; diagnostic accuracy 87%) and scintigraphy withTc-sestaMIBI (sensitivity 73.68%; specificity 96.05%; diagnostic accuracy 91.58%).Conclusions. The pMGC can be used effectively as an intraoperative method to find the correct location of the pathological parathyroid glands. The pMGC is more reliable than the currently used preoperative and intraoperative localisation techniques.

Radioguided Parathyroidectomy

2017 ◽  
pp. 3-15
Author(s):  
Herbert Chen
Keyword(s):  
Radioguided Parathyroidectomy

Diminished Dose Minimally Invasive Radioguided Parathyroidectomy: A Case for Radioguidance

2007 ◽  
Vol 73 (7) ◽  
pp. 669-672 ◽  
Author(s):  
Christopher J. You ◽  
John L. Zapas
Keyword(s):  
Parathyroid Hormone ◽  
Minimally Invasive ◽  
Frozen Section ◽  
Standard Dose ◽  
Intraoperative Mapping ◽  
Parathyroid Hormone Monitoring ◽  
Frozen Section Analysis ◽  
Radioguided Parathyroidectomy ◽  
Intraoperative Parathyroid Hormone ◽  
Section Analysis

Minimally invasive radioguided parathyroidectomy (MIRP) has been established as an alternative to bilateral neck exploration (BNE) for primary hyperparathyroidism. We investigate whether a diminished dose of technetium-99m sestamibi gives similar results to the standard dose. One hundred one patients were offered MIRP or diminished-dose MIRP (ddMIRP). Patients received intravenous Tc-99m sestamibi at a dose of either 25 mCi 1.5 hours or 5 mCi 1 hour preoperatively. The procedure was terminated when the 20 per cent rule was satisfied. All tissue was confirmed to be parathyroid tissue by frozen section analysis. In addition, intraoperative parathyroid hormone levels were measured in a majority of patients. Patients who failed IOM underwent BNE. Frozen section analysis and intraoperative parathyroid hormone monitoring were also performed in the BNEs. Postoperatively, serum calcium levels were measured at 1 week and 6 months. Fifteen per cent of patients were male and 85 per cent were female. The median age was 63 years (range, 25–89 years). The first 58 patients had the standard dose of 25 mCi, whereas 43 patients had ddMIRP. Six patients (10%) failed intraoperative mapping in the MIRP group and were found to have single-gland disease. Five patients (12%) failed intraoperative mapping in the ddMIRP group. However, two patients were identified to have multigland disease making the true failure rate of intraoperative mapping 7 per cent (three patients). Median operative times for MIRP, ddMIRP, and BNE were 40 minutes, 46 minutes, and 105 minutes, respectively. The 20 per cent rule was satisfied in 96 per cent of patients undergoing MIRP and 98 per cent of patients undergoing ddMIRP. Frozen section analysis and intraoperative parathyroid hormone monitoring did not result in a change in management. Median follow up was 193 days and serum calcium levels at 6 months were normal. Diminished-dose MIRP is a feasible alternative to standard-dose MIRP without compromising surgical outcomes.

scholarly journals Radioguided Parathyroidectomy Is Equally Effective for Both Adenomatous and Hyperplastic Glands

2003 ◽  
Vol 238 (3) ◽  
pp. 332-338 ◽  
Author(s):  
Herbert Chen ◽  
Eberhard Mack ◽  
James R. Starling
Keyword(s):  
Radioguided Parathyroidectomy

scholarly journals Feasibility and long-term results of focused radioguided parathyroidectomy using a "low" 37 MBq (1 mCi) 99mTc-sestamibi protocol

2006 ◽  
Vol 3 (1) ◽  
Author(s):  
Domenico Rubello ◽  
Adil Al-Nahhas ◽  
Giuliano Mariani ◽  
Milton D Gross ◽  
Lucia Rampin ◽  
...  
Keyword(s):  
Long Term Results ◽  
Radioguided Parathyroidectomy ◽  
99Mtc Sestamibi

Minimally Invasive Radioguided Parathyroidectomy

1999 ◽  
Vol 8 (3) ◽  
pp. 555-564 ◽  
Author(s):  
Damon Costello ◽  
James Norman
Keyword(s):  
Minimally Invasive ◽  
Radioguided Parathyroidectomy

CT-MIBI-SPECT Fusion Imaging Combined with Gamma Probe for Minimally Invasive Radioguided Parathyroidectomy (MIRP)

2010 ◽  
Vol 3 (4) ◽  
pp. 263-266
Author(s):  
Ashley L. Pistorio ◽  
David Goldenberg
Keyword(s):  
Minimally Invasive ◽  
Gamma Probe ◽  
Fusion Imaging ◽  
Radioguided Parathyroidectomy ◽  
Mibi Spect
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