scholarly journals Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease

2018 ◽  
Vol 2 (6) ◽  
pp. 644-653 ◽  
Author(s):  
Laurence Britton ◽  
Kim Bridle ◽  
Janske Reiling ◽  
Nishreen Santrampurwala ◽  
Leesa Wockner ◽  
...  
Keyword(s):  
Liver Disease ◽  
Insulin Sensitivity ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Iron Concentration ◽  
Hepatic Iron ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Iron Concentration

Relationships between Parameters of Insulin Sensitivity, Obesity and Liver Aminotransferases in Patients with Nonalcoholic Fatty Liver Disease

2007 ◽  
Vol 1 (4) ◽  
pp. 537-545
Author(s):  
Emil Fraenkel ◽  
Ivica Lazúrová ◽  
Peter Jarčuška ◽  
János Fehér ◽  
József Hamvas
Keyword(s):  
Liver Disease ◽  
Insulin Sensitivity ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver

scholarly journals Short-term exercise reduces markers of hepatocyte apoptosis in nonalcoholic fatty liver disease

2012 ◽  
Vol 113 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Ciaran E. Fealy ◽  
Jacob M. Haus ◽  
Thomas P. J. Solomon ◽  
Mangesh Pagadala ◽  
Chris A. Flask ◽  
...  
Keyword(s):  
Liver Disease ◽  
Insulin Sensitivity ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Fat Oxidation ◽  
Whole Body ◽  
Hepatocyte Apoptosis ◽  
Short Term ◽  
Nonalcoholic Fatty Liver

Increased hepatocyte apoptosis is a hallmark of nonalcoholic fatty liver disease (NAFLD) and contributes to the profibrogenic state responsible for the progression to nonalcoholic steatohepatitis (NASH). Strategies aimed at reducing apoptosis may result in better outcomes for individuals with NAFLD. We therefore examined the effect of a short-term exercise program on markers of apoptosis—plasma cytokeratin 18 (CK18) fragments, alanine aminotransferase (ALT), aspartate aminotransferase (AST), soluble Fas (sFas), and sFas ligand (sFasL)—in 13 obese individuals with NAFLD [body mass index 35.2 ± 1.2 kg/m2, >5% intrahepatic lipid (IHL) assessed by 1H-MR spectroscopy]. Exercise consisted of treadmill walking for 60 min/day on 7 consecutive days at ∼85% of maximal heart rate. Additionally, subjects underwent an oral glucose tolerance test and a maximal oxygen consumption (V̇o2max) test before and after the exercise intervention. The Matsuda index was used to assess insulin sensitivity. We observed significant decreases in CK18 fragments (558.4 ± 106.8 vs. 323.4 ± 72.5 U/l, P < 0.01) and ALT (30.2 ± 5.1 vs. 24.3 ± 4.8 U/l, P < 0.05), and an increase in whole body fat oxidation (49.3 ± 6.1 vs. 69.4 ± 7.1 mg/min, P < 0.05), while decreases in circulating sFasL approached statistical significance (66.5 ± 6.0 vs. 63.0 ± 5.7 pg/ml, P = 0.06), as did the relationship between percent change in circulating CK18 fragments and ALT (r = 0.55, P = 0.05). We also observed a significant correlation between changes in fat oxidation and circulating sFasL (rho = −0.65, P < 0.05). There was no change in IHL following the intervention (18.2 ± 2.5 vs. 17.5 ± 2.1%, NS). We conclude that short-term exercise reduces a circulatory marker of hepatocyte apoptosis in obese individuals with NAFLD and propose that changes in the proapoptotic environment may be mediated through improved insulin sensitivity and increased oxidative capacity.

No effect of resveratrol on VLDL-TG kinetics and insulin sensitivity in obese men with nonalcoholic fatty liver disease

2018 ◽  
Vol 20 (10) ◽  
pp. 2504-2509 ◽  
Author(s):  
Marianne K. Poulsen ◽  
Birgitte Nellemann ◽  
Bo Martin Bibby ◽  
Hans Stødkilde-Jørgensen ◽  
Steen B. Pedersen ◽  
...  
Keyword(s):  
Liver Disease ◽  
Insulin Sensitivity ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver

scholarly journals The A736V TMPRSS6 Polymorphism Influences Hepatic Iron Overload in Nonalcoholic Fatty Liver Disease

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e48804 ◽  
Author(s):  
Luca Valenti ◽  
Raffaela Rametta ◽  
Paola Dongiovanni ◽  
Benedetta M. Motta ◽  
Elena Canavesi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Iron Overload ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Hepatic Iron ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Iron Overload

scholarly journals Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease

Hepatology ◽  
2012 ◽  
Vol 55 (4) ◽  
pp. 1083-1093 ◽  
Author(s):  
Lars P. Bechmann ◽  
Amalia Gastaldelli ◽  
Diana Vetter ◽  
Gillian L. Patman ◽  
Laura Pascoe ◽  
...  
Keyword(s):  
Liver Disease ◽  
Insulin Sensitivity ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Insulin Sensitivity
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