Decision letter for "The influence of different intensity of treatment on hormonal markers of gonadal function in acute lymphoblastic leukemia survivors"

2019 ◽  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Gonadal Function ◽  
Intensity Of Treatment

The influence of different intensity of treatment on hormonal markers of gonadal function in acute lymphoblastic leukemia survivors

2019 ◽  
Vol 37 (5) ◽  
pp. 609-616
Author(s):  
Maryna Krawczuk‐Rybak ◽  
Marcin Płonowski ◽  
Elżbieta Leszczyńska ◽  
Eryk Latoch ◽  
Małgorzata Sawicka‐Żukowska ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Gonadal Function ◽  
Intensity Of Treatment

Cranial Irradiation Does Not Result in Pituitary-Gonadal Axis Dysfunction in Very Long-Term Male Survivors of Childhood Acute Lymphoblastic Leukemia.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 989-989
Author(s):  
Niels J. van Casteren ◽  
Rob Pieters ◽  
Gert Dohle ◽  
Manita van Baalen ◽  
Sebastian Neggers ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Conflicts Of Interest ◽  
Lymphoblastic Leukemia ◽  
Cranial Irradiation ◽  
Gonadal Function ◽  
Free T4 ◽  
Childhood All ◽  
Male Survivors ◽  
Igf I

Abstract Abstract 989 Poster Board I-11 Introduction: One of the risks of childhood cancer treatment is fertility impairment later in life. In the past a large proportion of children with acute lymphoblastic leukemia (ALL) has received cranial irradiation as part of their treatment. The aim of this study was to evaluate whether cranial irradiation negatively affects pituitary regulated gonadal function in male survivors of childhood ALL. Patients and Methods: We examined gonadal function, including Inhibin B, LH, FSH, testosterone, and pituitary axis function by measuring TSH, Free-T4 and IGF-I levels in 89 long-term male survivors of childhood ALL after a median follow-up time of 19 year (range 7-34 years). Results: Twenty-nine out of 89 male ALL survivors received cranial irradiation. Inhibin, FSH, LH, Testosterone, testicular volume as well as TSH and Free-T4 levels were not different in the cranial irradiated group as compared to the non-irradiated group (table 1). In contrast, IGF-I levels were significantly lower in the cranial irradiated group. Survivors treated with total body irradiation or testicular irradiation had significantly decreased gonadal function based on hormone levels. Conclusions: These data show that, in contrast to the negative influence on the growth hormone axis, cranial radiotherapy as part of ALL treatment does not have a deleterious long-term effect on the hypothalamic–pituitary-gonadal axis or pituitary-thyroid axis. Disclosures: No relevant conflicts of interest to declare.

Longitudinal gonadal function after bone marrow transplantation for acute lymphoblastic leukemia during childhood

1999 ◽  
Vol 3 (1) ◽  
pp. 38-44 ◽  
Author(s):  
E. I. E. Mayer ◽  
R. E. Dopfer ◽  
T. Klingebiel ◽  
H. Scheel‐walter ◽  
M. B. Ranke ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Lymphoblastic Leukemia ◽  
Gonadal Function

Evaluation of Gonadal Function Following Long-Term Treatment for Acute Lymphoblastic Leukemia in Girls

1987 ◽  
Vol 9 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Titania Pasqualini ◽  
María Eugenia Escobar ◽  
Horacio Domené ◽  
Federico Sackmann Muriel ◽  
Santiago Pavlovsky ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Term Treatment ◽  
Gonadal Function ◽  
Long Term Treatment
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