Urticaria Pigmentosa Due to Microsporum canis Infection in a Sphynx Cat – Case Report

A two- year-old Sphynx cat, an unneutered female with multiple erythematous papules with hyperpigmentation was presented. In skin biopsy, in the dermis, well differentiated monomorphic mast cells were found. Fungal culture was positive for Microsporum canis. Diagnosis of urticaria pigmentosa following M. canis infection was made. The animal was successfully treated with itraconazole orally and shampoo containing chlorhexidine and miconazole. To the authors’ knowledge, this is the first reported case of urticaria pigmentosa following the dermatophyte infection in a Sphynx cat.

Unusual Urticaria Pigmentosa in an Asian Man With Indolent Systemic Mastocytosis: A Case Report

Background: The diagnosis of mastocytosis remains challenging. Given that the disease has a low prevalence and its clinical presentations range from asymptomatic to severe life-threatening conditions, physicians’ lack of awareness of mastocytosis is the main barrier to its diagnosis. Skin involvement is common. In adults, skin lesions are highly suggestive of systemic mastocytosis; however, clinical demonstration of lesions is difficult if they are minimal in number. In Asian, who had dark brown skin color, urticaria pigmentosa was not easy to identify. Here we present the case of indolent systemic mastocytosis with an unusual urticaria pigmentosa. Case presentation: A 48-year-old man had had recurrent severe honeybee anaphylaxis since he was 23. He had small, subtle, brownish skin lesions on his chest and abdomen, which he and previous physicians had not recognized. The skin lesions were compatible with urticaria pigmentosa, also known as maculopapular cutaneous mastocytosis. His clinical findings and an elevated baseline tryptase level triggered a thorough systemic mastocytosis investigation. The skin and bone marrow were infiltrated by abnormal, spindle-shaped mast cells, and KIT and TET2 mutations were in the patient’s serum. The honeybee anaphylaxis mechanism in this patient was IgE mediated, supported by a positive result of specific IgE to honeybee. The final diagnosis was indolent systemic mastocytosis with IgE-mediated honeybee anaphylaxis. As venom immunotherapy is unavailable in Thailand, we prescribed treatment with a regular, oral, nonsedating H1-antihistamine and an epinephrine self-injector. At the 2-year follow-up, the patient had not progressed to advanced systemic mastocytosis nor experienced any anaphylactic episodes.Conclusion: Urticaria pigmentosa is a small, round, brown, or red maculopapular lesion. In the Asian population with dark brown skin color, physician should be exclusively careful examination, particularly in a hidden area and in anaphylaxis cases. Early recognition of urticaria pigmentosa in the adult patient might reduce the delay in diagnosis of indolent systemic mastocytosis.

Genotypic and phenotypic characteristics of Chinese neonates with cutaneous mastocytosis: a case report and literature review

Mastocytosis is an accumulation of clonal mast cells within tissues and it is most commonly caused by an activating mutation in the KIT gene. In this study, we report a neonatal case who presented with diffuse cutaneous mastocytosis (CM) at birth. In China, nine other cases of neonatal-onset CM have been reported in the literature since 2006. In those cases, diffuse CM and urticaria pigmentosa were the main symptoms, and mutations in exon 17 at codon 816 in KIT were identified.

Urticária pigmentosa no adulto: tratamento bem-sucedido em associação com fototerapia

Introdução: A urticária pigmentosa em adultos é uma forma de mastocitose rara e persistente, frequentemente com manifestações sistêmicas e acometimento da medula óssea, e manifestações cutâneas menos evidentes, ao contrário do que ocorre na infância. Objetivo: Relatar um caso de início na fase adulta, com lesões cutâneas leves, que evoluiu com sintomas de liberação histamínica, porém sem acometimento sistêmico. Metodologia: As informações foram obtidas através de revisão do prontuário, entrevista com o doente, registro fotográfico e revisão da literatura. Conclusão: O diagnóstico correto e a investigação precoce do acometimento de outros órgãos são importantes, bem como o tratamento adequado e prevenção de reações anafilactoides. A fototerapia é opção interessante de tratamento nos casos refratários.

Unique presentation of Urticaria Pigmentosa as a subcutaneous mass

No abstract available.

Infant Mastocytosis: Urticaria Pigmentosa an Entity to know

We are reporting a case of a 14 months year‑old boy with Fitzpatrick type 4 skin presented with multiple brownish skin lesions which started over the trunk and progressed to involve the face and limbs past six months Case report