Influence of P-glycoprotein inhibition on the distribution of the tricyclic antidepressant nortriptyline over the blood-brain barrier

2005 ◽  
Vol 20 (2) ◽  
pp. 149-153 ◽  
Author(s):  
Thomas B. Ejsing ◽  
Kristian Linnet
Keyword(s):  
Blood Brain Barrier ◽  
Tricyclic Antidepressant ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Glycoprotein Inhibition

Quantitative Investigation of the Impact of P-Glycoprotein Inhibition on Drug Transport across Blood-Brain Barrier in Rats

2010 ◽  
Vol 39 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Hiroshi Sugimoto ◽  
Hideki Hirabayashi ◽  
Yoshiaki Kimura ◽  
Atsutoshi Furuta ◽  
Nobuyuki Amano ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Drug Transport ◽  
Brain Barrier ◽  
Quantitative Investigation ◽  
P Glycoprotein ◽  
Blood Brain ◽  
The Impact ◽  
Glycoprotein Inhibition

P.4.004 P-glycoprotein inhibition enhances transport of the antidepressant imipramine across the blood-brain barrier

2012 ◽  
Vol 22 ◽  
pp. S86-S87
Author(s):  
F.E. O'Brien ◽  
G. Clarke ◽  
P. Fitzgerald ◽  
T.G. Dinan ◽  
B.T. Griffin ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Antidepressant Imipramine ◽  
Glycoprotein Inhibition

scholarly journals P-Glycoprotein inhibition at the blood-brain barrier visualized with (R)-[11C]verapamil μPET

2007 ◽  
Vol 7 (Suppl 2) ◽  
pp. A24
Author(s):  
Claudia Kuntner ◽  
Jens Bankstahl ◽  
Aiman Abrahim ◽  
Rudolf Karch ◽  
Johann Stanek ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Glycoprotein Inhibition

scholarly journals Influence of P-Glycoprotein Inhibition or Deficiency at the Blood–Brain Barrier on 18F-2-Fluoro-2-Deoxy-d-glucose (18F-FDG) Brain Kinetics

2015 ◽  
Vol 17 (3) ◽  
pp. 652-659 ◽  
Author(s):  
Nicolas Tournier ◽  
Wadad Saba ◽  
Sébastien Goutal ◽  
Philippe Gervais ◽  
Héric Valette ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
18F Fdg ◽  
Glycoprotein Inhibition

Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood–brain barrier can be studied with PET

NeuroImage ◽  
2006 ◽  
Vol 32 (3) ◽  
pp. 1134-1141 ◽  
Author(s):  
Stina Syvänen ◽  
Gunnar Blomquist ◽  
Margareta Sprycha ◽  
A. Urban Höglund ◽  
Magnus Roman ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Rat Blood ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Glycoprotein Inhibition

scholarly journals Lysophosphatidic acid and amitriptyline signal through LPA1R to reduce P-glycoprotein transport at the blood–brain barrier

2017 ◽  
Vol 38 (5) ◽  
pp. 857-868 ◽  
Author(s):  
David B Banks ◽  
Gary NY Chan ◽  
Rebecca A Evans ◽  
David S Miller ◽  
Ronald E Cannon
Keyword(s):  
Blood Brain Barrier ◽  
Lysophosphatidic Acid ◽  
Brain Parenchyma ◽  
Tricyclic Antidepressant ◽  
Brain Barrier ◽  
Transgenic Rat ◽  
Transport Activity ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Glycoprotein Transport

The blood–brain barrier is a microvascular network that (1) provides neuroprotection from metabolic and environmental toxins and (2) limits the delivery of therapeutics to the central nervous system (CNS). The ATP-binding cassette transporter P-glycoprotein contributes to the latter by actively pumping clinical substrates back into circulation before they can reach the brain parenchyma. Targeting P-glycoprotein has proven effective in increasing the delivery of therapeutics to their cerebral targets. We provide a novel mechanism to achieve this end in functioning, intact rat brain capillaries, whereby the bioactive phospholipid lysophosphatidic acid (LPA) and tricyclic antidepressant (TCA) amitriptyline reduce basal P-glycoprotein transport activity through a distinct lysophosphatidic acid 1 receptor-mediated signaling cascade that requires G-protein coupling, Src kinase, and ERK 1/2. Furthermore, we demonstrate the ability of LPA and TCA amitriptyline to decrease induced P-glycoprotein transport activity in a human SOD1 transgenic rat model of amyotrophic lateral sclerosis. This work may translate to new clinical strategies for increasing the cerebral penetration of therapeutics in patients suffering from CNS diseases marked by exacerbated pharmacoresistance.

scholarly journals Effect of P-glycoprotein inhibition at the blood-brain barrier on brain distribution of (R)-[11C]verapamil in elderlyvs.young subjects

2017 ◽  
Vol 83 (9) ◽  
pp. 1991-1999 ◽  
Author(s):  
Martin Bauer ◽  
Beatrix Wulkersdorfer ◽  
Rudolf Karch ◽  
Cécile Philippe ◽  
Walter Jäger ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Brain Distribution ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Glycoprotein Inhibition

scholarly journals P-glycoprotein inhibition increases the transport of dauricine across the blood-brain barrier

2013 ◽  
Vol 9 (3) ◽  
pp. 985-988 ◽  
Author(s):  
PEI-LIANG DONG ◽  
HUA HAN ◽  
TIAN-YU ZHANG ◽  
BINGYOU YANG ◽  
QIU-HONG WANG ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Glycoprotein Inhibition
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