scholarly journals Increased risk of grade IV neutropenia after administration of 5-fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: High prevalence of the IVS14+1g>a mutation

2002 ◽  
Vol 101 (3) ◽  
pp. 253-258 ◽  
Author(s):  
André B.P. Van Kuilenburg ◽  
Rutger Meinsma ◽  
Lida Zoetekouw ◽  
Albert H. Van Gennip
Keyword(s):  
Dehydrogenase Deficiency ◽  
Dihydropyrimidine Dehydrogenase ◽  
Increased Risk ◽  
High Prevalence ◽  
Dihydropyrimidine Dehydrogenase Deficiency

5-Fluorouracil Neurotoxicity in the Absence of Dihydropyrimidine Dehydrogenase Deficiency Case Report

2022 ◽  
pp. 194187442110689
Author(s):  
Rebecca Jules ◽  
Arushi Thaper ◽  
Ryan Foster ◽  
Pouya Ameli ◽  
Christopher Robinson ◽  
...  
Keyword(s):  
Case Report ◽  
Adverse Reactions ◽  
Colorectal Adenocarcinoma ◽  
Dehydrogenase Deficiency ◽  
Dihydropyrimidine Dehydrogenase ◽  
Severe Complication ◽  
Diffusion Restriction ◽  
Increased Risk ◽  
Dihydropyrimidine Dehydrogenase Deficiency ◽  
Leucovorin Calcium

5 fluorouracil (5-FU)-related neurotoxicity is a rare and severe complication of 5-FU administration. Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with an increased risk of serious adverse reactions due to its role in 5-FU metabolism. We report a case of acute reversible neurotoxicity with global areas of diffusion restriction in a patient with colorectal adenocarcinoma being treated with leucovorin calcium, 5-fluorouracil, and oxaliplatin (FOLFOX) without DPD deficiency following uridine triacetate administration.

Dihydropyrimidine Dehydrogenase Deficiency Caused by a Novel Genomic Deletion c.505_513del ofDPYD

2010 ◽  
Vol 29 (4-6) ◽  
pp. 509-514 ◽  
Author(s):  
A. B. P. van Kuilenburg ◽  
J. Meijer ◽  
G. Gökcay ◽  
T. Baykal ◽  
M. E. Rubio-Gozalbo ◽  
...  
Keyword(s):  
Dehydrogenase Deficiency ◽  
Dihydropyrimidine Dehydrogenase ◽  
Genomic Deletion ◽  
Dihydropyrimidine Dehydrogenase Deficiency

Dihydropyrimidine Dehydrogenase Deficiency

2009 ◽  
pp. 534-535
Author(s):  
Dieter Metze ◽  
Tam Nguyen ◽  
Birgit Haack ◽  
Alexander K. C. Leung ◽  
Noriko Miyake ◽  
...  
Keyword(s):  
Dehydrogenase Deficiency ◽  
Dihydropyrimidine Dehydrogenase ◽  
Dihydropyrimidine Dehydrogenase Deficiency
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