Depressedin vitro peripheral blood lymphocyte response to mitogens in cancer patients: The role of suppressor cells

1977 ◽  
Vol 19 (5) ◽  
pp. 605-613 ◽  
Author(s):  
Marek Zembala ◽  
Bozena Mytar ◽  
Tadeusz Popiela ◽  
Geoffrey L. Asherson
Keyword(s):  
Cancer Patients ◽  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Blood Lymphocyte ◽  
Suppressor Cells ◽  
Lymphocyte Response

scholarly journals Anti-inflammatory and immunomodulating effects of clarithromycin in patients with cystic fibrosis lung disease

2004 ◽  
Vol 13 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Alexander L. Pukhalsky ◽  
Galina V. Shmarina ◽  
Nikolai I. Kapranov ◽  
Svetlana N. Kokarovtseva ◽  
Daria Pukhalskaya ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Blood Lymphocyte ◽  
Drug Prescription ◽  
Neutrophil Infiltration ◽  
Interferon Γ ◽  
Interleukin 4 ◽  
Prolonged Treatment ◽  
Lymphocyte Response

BACKGROUND and aim: Macrolide antibiotics are widely used in the treatment of suppurative lung diseases including cystic fibrosis (CF), the most common inherited fatal disease in the Caucasian population. This condition is characterized by secondaryPseudomonasinfection resulting in neutrophil infiltration within the airways. The aim of the study was to investigate the evolution of inflammatory process in CF patients receiving long-term clarithromycin therapy.Methods: Twenty-seven CF patients (mean age, 12 years) were enrolled into the study. Beside the basic therapy the patients were treated with clarithromycin at a dose of 250 mg every other day orally. All patients were routinely examined every 3 months. Blood and sputum were collected before clarithromycin treatment and then again 3, 6 and 12 months after the drug prescription. Cytokine concentrations (tumor necrosis factor-α, interleukin-8, interleukin-4, interferon-γ) in the sputum and plasma were assayed. Peripheral blood lymphocyte response to phytohemagglutinin was also evaluated.Results: Clarithromycin treatment resulted in a marked reduction of the cytokine levels both in the sputum and plasma specimens. At the same time, the interferon-γ/interleukin-4 ratio has been significantly elevated. In addition, a sustained increase of peripheral blood lymphocyte response to phytohemagglutinin was demonstrated. These changes were associated with a significant improvement of the lung function.Conclusions: The beneficial effect of the prolonged treatment of CF patients with a 14-membered ring macrolide antibiotic clarithromycin seems to be associated not only with down-regulation of the inflammatory response, but also with immunological changes including the switch from Th2 to Th1 type response.

scholarly journals Peripheral blood lymphocyte response to acute infections in humans.

1977 ◽  
Vol 16 (1) ◽  
pp. 110-114 ◽  
Author(s):  
J D Thorley ◽  
J W Smith ◽  
J P Luby ◽  
J P Sanford
Keyword(s):  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Blood Lymphocyte ◽  
Lymphocyte Response ◽  
Acute Infections

Human splenic and peripheral blood lymphocyte response to lipopolysaccharide

1981 ◽  
Vol 57 (2) ◽  
pp. 400-407 ◽  
Author(s):  
D.N. Ilfeld ◽  
M.K. Cathcart ◽  
R.S. Krakauer ◽  
M. Blaese
Keyword(s):  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Blood Lymphocyte ◽  
Lymphocyte Response
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