Long‐term arsenic exposure impairs differentiation in mouse embryonal stem cells

2020 ◽  
Author(s):  
Benjamin D. McMichael ◽  
M. Chiara Perego ◽  
Caitlin L. Darling ◽  
Rebekah L. Perry ◽  
Sarah C. Coleman ◽  
...  
Keyword(s):  
Stem Cells ◽  
Arsenic Exposure ◽  
Embryonal Stem Cells ◽  
Embryonal Stem

Expression of c-myb in embryonal carcinoma cells and embryonal stem cells

1989 ◽  
Vol 42 (1) ◽  
pp. 24-27 ◽  
Author(s):  
P. Julian Dyson ◽  
Francoise Poirier ◽  
Roger J. Watson
Keyword(s):  
Stem Cells ◽  
Embryonal Carcinoma ◽  
Carcinoma Cells ◽  
Embryonal Carcinoma Cells ◽  
Embryonal Stem Cells ◽  
Embryonal Stem

The gene for erythropoietin receptor is expressed in multipotential hematopoietic and embryonal stem cells: evidence for differentiation stage-specific regulation

1992 ◽  
Vol 12 (4) ◽  
pp. 1815-1826
Author(s):  
C Heberlein ◽  
K D Fischer ◽  
M Stoffel ◽  
J Nowock ◽  
A Ford ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hematopoietic Cells ◽  
Cell Surface Receptor ◽  
Erythroid Cell ◽  
Specific Cell ◽  
Erythroid Cells ◽  
Expression Levels ◽  
Embryonal Stem Cells ◽  
First Intron ◽  
Embryonal Stem

The principal regulator of erythropoiesis is the glycoprotein erythropoietin, which interacts with a specific cell surface receptor (EpoR). A study aimed at analyzing EpoR gene regulation has shown that both pluripotent embryonal stem cells and early multipotent hematopoietic cells express EpoR transcripts. Commitment to nonerythroid lineages (e.g., macrophage or lymphocytic) results in the shutdown of EpoR gene expression, whereas commitment to the erythroid lineage is concurrent with or followed by dramatic increases in EpoR transcription. To determine whether gene activity could be correlated with chromatin alterations, DNase-hypersensitive sites (HSS) were mapped. Two major HSS located in the promoter region and within the first intron of the EpoR gene are present in all embryonal stem and hematopoietic cells tested, the intensities of which correlate well with EpoR expression levels. In addition, a third major HSS also located within the first intron of the EpoR gene is uniquely present in erythroid cells that express high levels of EpoR. Transfection assays show that sequences surrounding this major HSS impart erythroid cell-specific enhancer activity to a heterologous promoter and that this activity is at least in part mediated by GATA-1. These data, together with concordant expression levels of GATA-1 and EpoR in both early multipotent hematopoietic and committed erythroid cells, support a regulatory role of the erythroid cell-specific transcription factor GATA-1 in EpoR transcription in these cells. However, the lack of significant levels of GATA-1 expression in embryonal stem cells implies an alternative regulatory mechanism of EpoR transcription in cells not committed to the hematopoietic lineage.

Hematopoietic Differentiation of Embryonal Stem Cells in vitro.

1996 ◽  
pp. 3-10
Author(s):  
Nicholas Hole ◽  
Roland Leung ◽  
Lobat Doostdar ◽  
Ursula Menzel ◽  
Kay Samuel ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hematopoietic Differentiation ◽  
Embryonal Stem Cells ◽  
Embryonal Stem

scholarly journals Human mini-chromosomes in mouse embryonal stem cells

1997 ◽  
Vol 6 (8) ◽  
pp. 1375-1382 ◽  
Author(s):  
M. Shen
Keyword(s):  
Stem Cells ◽  
Embryonal Stem Cells ◽  
Embryonal Stem

scholarly journals Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain.

1990 ◽  
Vol 9 (11) ◽  
pp. 3723-3732 ◽  
Author(s):  
N. Suzuki ◽  
H. Rohdewohld ◽  
T. Neuman ◽  
P. Gruss ◽  
H. R. Schöler
Keyword(s):  
Stem Cells ◽  
Transcription Factor ◽  
Developing Brain ◽  
Embryonal Stem Cells ◽  
Embryonal Stem

scholarly journals Dissecting the retinoid‐induced differentiation of F9 embryonal stem cells by integrative genomics

2011 ◽  
Vol 7 (1) ◽  
pp. 538 ◽  
Author(s):  
Marco A Mendoza‐Parra ◽  
Mannu Walia ◽  
Martial Sankar ◽  
Hinrich Gronemeyer
Keyword(s):  
Stem Cells ◽  
Integrative Genomics ◽  
Induced Differentiation ◽  
Embryonal Stem Cells ◽  
Embryonal Stem

scholarly journals Increased probability of expression from modified retroviral vectors in embryonal stem cells and embryonal carcinoma cells.

1997 ◽  
Vol 71 (12) ◽  
pp. 9466-9474 ◽  
Author(s):  
P B Robbins ◽  
X J Yu ◽  
D M Skelton ◽  
K A Pepper ◽  
R M Wasserman ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonal Carcinoma ◽  
Retroviral Vectors ◽  
Carcinoma Cells ◽  
Embryonal Carcinoma Cells ◽  
Embryonal Stem Cells ◽  
Embryonal Stem
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