scholarly journals Assessment of Bone Microarchitecture in Postmenopausal Women on Long-Term Bisphosphonate Therapy With Atypical Fractures of the Femur

2014 ◽  
Vol 29 (4) ◽  
pp. 999-1004 ◽  
Author(s):  
Maria Belen Zanchetta ◽  
Maria Diehl ◽  
Mirena Buttazzoni ◽  
Ana Galich ◽  
Fernando Silveira ◽  
...  
2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Shen Hwa Vun ◽  
Yahya Husami ◽  
Sajan Shareef ◽  
Diane Bramley

Cases of osteonecrosis of the jaw, insufficiency fractures and atypical low energy or atraumatic fractures of pelvis, femur (subtrochanteric/mid-shaft/distal-third), tibia, fibula, metatarsal, humerus, and ulna related to long-term bisphosphonate therapy have been reported in the literature. We present the case of an acute nontraumatic clavicle fracture, associated with long-term bisphosphonate therapy, which to our knowledge has not been reported previously. This case highlights the need of critical evaluation of patients with atypical fractures during long-term bisphosphonate therapy.


Author(s):  
Leena Palomo ◽  
Maria Clarinda A. Buencamino-Francisco ◽  
John J. Carey ◽  
Mala Sivanandy ◽  
Holly Thacker

2019 ◽  
Vol 12 (7) ◽  
pp. e229366 ◽  
Author(s):  
Juan Tan ◽  
Hiroshige Sano ◽  
Kenneth Poole

A 35-year-old man with juvenile idiopathic arthritis since childhood presented with bilateral atypical tibial fractures, followed by a later, single atypical fracture of the femur. The fractures were associated with 6 years of oral alendronate treatment immediately followed by subcutaneous denosumab therapy and later teriparatide therapy for osteoporosis. Atypical fractures are known to occur in the femur following bisphosphonate therapy; however, there are only a few documented cases of atypical fractures in the tibia. Our case highlights a rare but serious complication of a commonly prescribed antiresorptive agent. It also shows that teriparatide, while helpful in increasing bone mass, does not fully prevent the development of atypical fractures. Careful investigation should be considered in patients on long-term antiresorptive therapy presenting with bony tenderness to exclude an atypical fracture.


2011 ◽  
pp. P1-232-P1-232
Author(s):  
Francisco Antonio Padilla ◽  
Ansu Varughese Joy ◽  
Pamela Taxel ◽  
Faryal Mirza ◽  
Lisanne Cirullo

2021 ◽  
Vol 3 ◽  
pp. 45-53
Author(s):  
Sayed Hashim AlQarooni ◽  
Ugo Ruggiero ◽  
Sri Priya Suresh

Osteoporosis is a ubiquitous and chronic process that affects an increasing number of people each year. Various forms of treatment are currently used including bisphosphonates which have been linked to atypical fractures of the femur. We present a case series of eight osteoporosis patients who developed atypical femoral fractures, while on bisphosphonate therapy. This pictorial review aims to increase awareness of bisphosphonate-related atypical fractures, discuss the current literature recommendations, and provide clear learning points from each case-based discussion.


Bone Reports ◽  
2021 ◽  
pp. 101112
Author(s):  
Matthew D. Smith ◽  
Olen J. Haseman ◽  
Jorge A. Velez Garza ◽  
Jan M. Bruder

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