YAP regulates periodontal ligament cell differentiation into myofibroblast interacted with RhoA/ROCK pathway

2018 ◽  
Vol 234 (4) ◽  
pp. 5086-5096 ◽  
Author(s):  
Yao He ◽  
Hui Xu ◽  
Zichao Xiang ◽  
Hongyou Yu ◽  
Li Xu ◽  
...  
2004 ◽  
Vol 75 (5) ◽  
pp. 709-716 ◽  
Author(s):  
Satoshi Ishikawa ◽  
Kengo Iwasaki ◽  
Motohiro Komaki ◽  
Isao Ishikawa

2009 ◽  
Vol 27 (5) ◽  
pp. 274-279 ◽  
Author(s):  
X. E. Dereka ◽  
C. E. Markopoulou ◽  
A. Mamalis ◽  
I. A. Vrotsos

1999 ◽  
Vol 70 (9) ◽  
pp. 1039-1045 ◽  
Author(s):  
Wen-Lang Lin ◽  
Hua-Hong Chien ◽  
Moon-Il Cho

2014 ◽  
Vol 103 (6) ◽  
pp. 1991-1998 ◽  
Author(s):  
Anders Skodje ◽  
Shaza Bushra M. Idris ◽  
Yang Sun ◽  
Sushma Bartaula ◽  
Kamal Mustafa ◽  
...  

2007 ◽  
Vol 86 (10) ◽  
pp. 980-985 ◽  
Author(s):  
S. Lossdörfer ◽  
M. Sun ◽  
W. Götz ◽  
M. Dard ◽  
A. Jäger

Enamel matrix derivative (EMD) has been used successfully to aid periodontal repair. We sought to elucidate the mechanism of action of EMD and hypothesized that combined exposure to EMD and parathyroid hormone (PTH), which acts anabolicly when administered intermittently, would enhance periodontal ligament cell proliferation, differentiation, and local factor production. Confluent human periodontal ligament cells were exposed to EMD continuously or to PTH(1-34) intermittently, or a combination of both. Cell number, alkaline phosphatase activity, osteocalcin, and osteoprotegerin production were determined. Continuous challenge with EMD resulted in an increase of the differentiation parameters and osteoprotegerin production, while simultaneously inhibiting proliferation. Intermittent PTH(1-34) administration exerted opposite effects. Combined administration of EMD and PTH(1-34) weakened or even nullified the effects seen for the agents alone. These results suggest that EMD promotes periodontal ligament cell differentiation and osteoprotegerin production, potentially resulting in a microenvironment supporting periodontal repair, whereas combining EMD and PTH(1-34) failed to prove beneficial in this respect.


Author(s):  
Taiga Ono ◽  
Atsushi Tomokiyo ◽  
Keita Ipposhi ◽  
Kozue Yamashita ◽  
M Anas Alhasan ◽  
...  

2001 ◽  
Vol 80 (3) ◽  
pp. 881-886 ◽  
Author(s):  
Y. Tsuboi ◽  
T. Nakanishi ◽  
T. Takano-Yamamoto ◽  
M. Miyamoto ◽  
T. Yamashiro ◽  
...  

2018 ◽  
Vol 154 (6) ◽  
pp. 788-796 ◽  
Author(s):  
Tadasu Sugimori ◽  
Masaru Yamaguchi ◽  
Mami Shimizu ◽  
Jun Kikuta ◽  
Takuji Hikida ◽  
...  

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