Evaluation of Aztreonam Dosing Regimens in Patients With Normal and Impaired Renal Function: A Population Pharmacokinetic Modeling and Monte Carlo Simulation Analysis

2016 ◽  
Vol 57 (3) ◽  
pp. 336-344 ◽  
Author(s):  
Hongmei Xu ◽  
Wangda Zhou ◽  
Diansong Zhou ◽  
Jianguo Li ◽  
Nidal Al-Huniti
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Renal Function ◽  
Impaired Renal Function ◽  
Simulation Analysis ◽  
Pharmacokinetic Modeling ◽  
Population Pharmacokinetic ◽  
Population Pharmacokinetic Modeling ◽  
Dosing Regimens

Simplifying Piperacillin/Tazobactam Dosing: Pharmacodynamics of Utilizing Only 4.5 or 3.375 g Doses for Patients With Normal and Impaired Renal Function

2016 ◽  
Vol 30 (6) ◽  
pp. 593-599 ◽  
Author(s):  
Abrar K. Thabit ◽  
Mordechai Grupper ◽  
David P. Nicolau ◽  
Joseph L. Kuti
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Renal Function ◽  
Impaired Renal Function ◽  
Inhibitory Concentration ◽  
Prolonged Infusion ◽  
Target Attainment ◽  
Dosing Regimens ◽  
Function Range ◽  
Prescribing Information

Objectives: To evaluate the pharmacodynamic exposure of piperacillin/tazobactam across the renal function range using 4.5 or 3.375 g dosing regimens. Methods: A 5000-patient Monte Carlo simulation was conducted to determine the probability of achieving 50% free time above the minimum inhibitory concentration ( fT > MIC) for piperacillin. Proposed regimens, using solely 4.5 or 3.375 g strengths, were compared with regimens listed in piperacillin/tazobactam prescribing information over creatinine clearance (CrCl) ranges of 120 mL/min to hemodialysis. The probability of target attainment (PTA) at MICs ≤ 16 μg/mL was compared between proposed and standard regimens. Results: At CrCl 41 to 120 mL/min, prolonged infusions of 4.5 g (3 hours) and 3.375 g (4 hours) every 6 hours resulted in ≥95% PTA versus ≥76% for standard regimens (0.5 hour). At CrCl 20 to 40 mL/min, 4.5 and 3.375 g every 8 hours as prolonged infusions achieved slightly higher PTA (≥98%) versus standard regimens (≥93%). Similarly, PTA achieved with prolonged infusions of 4.5 and 3.375 g every 12 hours (≥93%) was comparable with those of standard regimens (≥91%) at CrCl 1 to 19 mL/min. In hemodialysis, 100% PTA was achieved with prolonged infusion regimens. Conclusion: Piperacillin/tazobactam regimens designed around the 4.5 or 3.375 g dose and prolonged infusions provided similar or better PTA at MICs ≤ 16 μg/mL compared with standard regimens. These observations may support the stocking and use of a single piperacillin/tazobactam strength to simplify dosing.

Population pharmacokinetic modeling and Monte Carlo simulation of varying doses of intravenous metronidazole

2006 ◽  
Vol 55 (4) ◽  
pp. 303-309 ◽  
Author(s):  
Kelly A. Sprandel ◽  
George L. Drusano ◽  
David W. Hecht ◽  
John C. Rotschafer ◽  
Larry H. Danziger ◽  
...  
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Pharmacokinetic Modeling ◽  
Population Pharmacokinetic ◽  
Population Pharmacokinetic Modeling

scholarly journals Population Pharmacokinetic Modeling of Vancomycin in Thai Patients with Heterogeneous and Unstable Renal Function

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Siriluk Jaisue ◽  
Cholatip Pongsakul ◽  
David Z. D’Argenio ◽  
Pakawadee Sermsappasuk
Keyword(s):  
Renal Function ◽  
Pharmacokinetic Modeling ◽  
Population Pharmacokinetic ◽  
Population Pharmacokinetic Modeling

Simplified dosing regimens of teicoplanin for patient groups stratified by renal function and weight using Monte Carlo simulation

2012 ◽  
Vol 40 (4) ◽  
pp. 344-348 ◽  
Author(s):  
Takaaki Yamada ◽  
Toshiharu Nonaka ◽  
Takahisa Yano ◽  
Toshio Kubota ◽  
Nobuaki Egashira ◽  
...  
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Renal Function ◽  
Dosing Regimens ◽  
Patient Groups
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