Choroid plexus tumors: Antenatal diagnosis and follow-up

1990 ◽  
Vol 18 (7) ◽  
pp. 575-578 ◽  
Author(s):  
G. Body ◽  
E. Darnis ◽  
J. H. Soutoul ◽  
D. Pourcelot ◽  
J. J. Santini ◽  
...  
Keyword(s):  
Choroid Plexus ◽  
Antenatal Diagnosis ◽  
Choroid Plexus Tumors

scholarly journals Treatment of choroid plexus tumors: a 20-year single institutional experience

2012 ◽  
Vol 10 (5) ◽  
pp. 398-405 ◽  
Author(s):  
Chetan Bettegowda ◽  
Owoicho Adogwa ◽  
Vivek Mehta ◽  
Kaisorn L. Chaichana ◽  
Jon Weingart ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Choroid Plexus ◽  
Multivariate Regression ◽  
Tumor Recurrence ◽  
Multivariate Regression Analysis ◽  
Tumor Location ◽  
Choroid Plexus Tumors ◽  
Presenting Symptoms ◽  
Institutional Experience

Object Choroid plexus tumors (CPTs) are rare intracranial neoplasms that constitute approximately 2%–5% of all pediatric brain tumors. Most of these tumors present with severe hydrocephalus. The optimal perioperative management and oncological care remain a matter of debate. The authors present the epidemiological and clinical features of CPTs from a 20-year single-institutional experience. Methods A total of 39 consecutive patients with pathologically proven CPTs (31 choroid plexus papillomas [CPPs] and 8 choroid plexus carcinomas [CPCs]) were included in this series. Patient demographics, clinical presentation, comorbidities, indications for surgery, radiological studies, tumor location, and all operative variables were reviewed for each case. Multivariate regression analysis was performed to identify independent predictors of tumor recurrence and survival. Results The overall mean age (± SD) was 13.13 ± 19.59 years (15.27 ± 21.10 years in the CPP group and 3.66 ± 3.59 years in the CPC group). Hydrocephalus was noted at presentation in 34% of patients. The most common presenting symptoms were headache (32%) and nausea/vomiting (26%). Gross-total resection (GTR) was achieved in 86% of CPPs and in 71% of CPCs (p = 0.57). There was 100% survival in patients with CPPs observed at the 5- and 10-year follow-up and 71% survival in patients with CPCs at the 5-year follow-up. In a multivariate regression analysis, a diagnosis of papilloma, preoperative vision changes, or hydrocephalus; right ventricle tumor location; and GTR were all independently associated with a decreased likelihood of tumor recurrence at last follow-up. Conclusions The authors' study suggests that patients with CPCs are more likely to experience local recurrence and metastasis; hence, GTR with chemotherapy and radiotherapy, particularly for CPCs, is pivotal in preventing recurrence and prolonging survival. While GTR was important for local control following resection of CPPs, it had a minimal effect on prolonging survival in this patient cohort.

scholarly journals RARE-26. RETROSPECTIVE ANALYSIS OF PEDIATRIC CHOROID PLEXUS TUMORS

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii447-iii448
Author(s):  
Yoshiko Nakano ◽  
Atsufumi Kawamura ◽  
Yuko Watanabe ◽  
Ryuta Saito ◽  
Masayuki Kanemori ◽  
...  
Keyword(s):  
Choroid Plexus ◽  
Survival Rates ◽  
Choroid Plexus Papilloma ◽  
Clinical Information ◽  
Local Relapse ◽  
Current Status ◽  
Choroid Plexus Tumors ◽  
Li Fraumeni Syndrome ◽  
Plexus Papilloma

Abstract BACKGROUND Choroid plexus tumors (CPT) include choroid plexus papilloma (CPP), atypical choroid plexus papilloma (aCPP), and choroid plexus carcinoma (CPC). Because of their rarity, limited data are available on the current status of treatment and outcomes for pediatric CPTs. METHOD We retrospectively reviewed clinical information on patients with CPT patients aged between 0 and 30 years at diagnosis and were treated in 8 institutions in Japan. RESULTS Of forty-two cases initially diagnosed as CPT, 18 cases were reviewed by central pathologists. As a result, the diagnosis of CPC or aCPP in five cases were changed to other tumors including AT/RT and astroblastoma. The remaining 37 cases were subjected to analysis. Median age at diagnosis was two years (0 to 25) and the mean follow-up period was seven years. All 26 patients with CPP (n=20) or aCPP (n=6) underwent gross-total resection without adjuvant therapy. Of them 24 patients are alive without recurrence. Four patients of patients with CPC (n=11) died of cancer. Five patients including three patients experienced local relapse, achieved complete remission after resection of tumor plus chemoradiotherapy. All three patients with dissemination of CPC at diagnosis or relapse died of the disease. At least three patients were diagnosed with Li-Fraumeni syndrome: one died of medulloblastoma and one patient developed osteosarcoma. CONCLUSION Compared with the excellent prognosis of CPP, the survival rates for CPC, especially disseminated CPC are unsatisfactory. Our results also underline the importance of considering genetic testing of TP53 for patients with CPC.

scholarly journals Infratentorial choroid plexus tumors in children

2020 ◽  
Vol 36 (8) ◽  
pp. 1761-1766 ◽  
Author(s):  
S. Joy Trybula ◽  
Constantine Karras ◽  
Robin M. Bowman ◽  
Tord D. Alden ◽  
Arthur J. DiPatri ◽  
...  
Keyword(s):  
Adjuvant Therapy ◽  
Choroid Plexus ◽  
Surgical Resection ◽  
Fourth Ventricle ◽  
Gross Total Resection ◽  
Incomplete Resection ◽  
Total Resection ◽  
Who Grade ◽  
Choroid Plexus Tumors

Abstract Objective Choroid plexus tumors (CPTs) are rare pediatric intracranial neoplasms, and mostly occur in the lateral ventricle. CPTs located in the infratentorial location are considered to be rare in the pediatric population. We present a series of eight patients treated in the last decade at our institution focusing on clinical presentations and their outcome after excision. Methods We performed an institutional retrospective review of patients who underwent surgical resection of infratentorial CPTs during the period from 2008 to 2017. Patients’ charts were reviewed for demographic data, clinical presentation, surgical treatment, and follow-up. Results There were eight patients (6 females and 2 males), with mean age for the cohort at presentation was 9.0 years. They represent 75% of 12 CPTs of all locations treated at the same period in our institution. These 8 infratentorial CPTs were in the fourth ventricle in seven, and in the cerebellopontine angle (CPA) in one. Seven patients had choroid plexus papillomas (WHO grade I) and 1 had an atypical choroid plexus papilloma (WHO grade II). Gross total resection was attempted in all patients. However, two of 3 patients with fourth ventricle floor invasion had subtotal resection with a thin layer of tumor left on the floor. The remaining 6 had a gross total resection. Six patients with preoperative hydrocephalus had a perioperative external ventricular drainage but none required permanent shunting after tumor resection. None showed recurrence/tumor progression without adjuvant therapy during the follow-up period of 20 months to 11 years. Conclusion Infratentorial dominance among pediatric CPTs in this series contradicts previous reports. Infratentorial CPTs are amenable to surgical resection. Unresected small residuals due to invasion to the fourth ventricle floor showed no regrowth during 2 to 3 years follow-up without adjuvant therapy. However, these patients with incomplete resection need watchful observations.

scholarly journals HGG-27. CLINICAL ANALYSIS OF CHOROID PLEXUS TUMORS

2019 ◽  
Vol 21 (Supplement_2) ◽  
pp. ii92-ii92
Author(s):  
Yoshiko Nakano ◽  
Ryuta Saito ◽  
Masahiro Kanamori ◽  
Atsushi Kawamura ◽  
Taishi Nakamura ◽  
...  
Keyword(s):  
Choroid Plexus ◽  
Clinical Analysis ◽  
Choroid Plexus Tumors

scholarly journals Endoscopic monoportal removal of a choroid plexus papilloma in the posterior third ventricle in a child

2015 ◽  
Vol 16 (1) ◽  
pp. 107-111 ◽  
Author(s):  
Albert A. Sufianov ◽  
Saidi S. K. Gaibov ◽  
Rinat A. Sufianov
Keyword(s):  
Choroid Plexus ◽  
Tumor Recurrence ◽  
Third Ventricle ◽  
Brain Mri ◽  
Choroid Plexus Papilloma ◽  
Male Infant ◽  
Invasive Technique ◽  
Endoscopic Removal ◽  
Who Grade

Currently, only a few reports describe the minimally invasive removal of choroid plexus papillomas (CPPs) and, to the best of the authors' knowledge, no reports detail the resection of such a papilloma through an endoscopic approach in infants. The authors here describe the endoscopic removal of a third ventricle CPP in a child. A 5-month-old male infant presented with progressive macrocephaly, vomiting, and convulsions. A lesion in the posterior third ventricle was detected on brain MRI. Because of the patient's very young age, neuroendoscopy was used as the least invasive technique. The tumor was completely resected through a monoportal neuroendoscopic approach. Histologically, the tumor was classified as a WHO Grade I CPP. After surgery, the patient's condition improved, with no complications during his recovery. Ten-month follow-up neuroimaging revealed no evidence of tumor recurrence or progressive hydrocephaly. In view of the successful neuroendoscopic excision of this posterior third ventricle CPP, the authors believe that this method seems promising in the treatment of young children with intraventricular lesions.

Choroid Plexus Tumors and Meningiomas

2020 ◽  
pp. 326-352
Author(s):  
Kenneth K. Wong ◽  
Elwira Szychot ◽  
Jennifer A. Cotter ◽  
Mark Krieger
Keyword(s):  
Choroid Plexus ◽  
Choroid Plexus Tumors

scholarly journals Increased NG2 and SOX2 expression is associated with high-grade choroid plexus tumors

2017 ◽  
Vol 14 (2) ◽  
pp. 1802-1806 ◽  
Author(s):  
Peng Zhao ◽  
Zichao Feng ◽  
Qichao Qi ◽  
Bin Huang ◽  
Anjing Chen ◽  
...  
Keyword(s):  
Choroid Plexus ◽  
High Grade ◽  
Choroid Plexus Tumors ◽  
Sox2 Expression

Prenatal diagnosis of a giant fetal hepatic hemangioma: a case report

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Alain Daher ◽  
Marc Dommergues ◽  
Assaad Kesrouani ◽  
Claude Vibert-Guigue ◽  
Jacky Nizard
Keyword(s):  
Spontaneous Regression ◽  
Antenatal Diagnosis ◽  
Fetal Liver ◽  
Color Doppler ◽  
Hepatic Hemangioma ◽  
Vascular Pattern ◽  
Image Size ◽  
Fetal Protection ◽  
Cesarean Birth

AbstractWe report a case of uncomplicated giant fetal hepatic hemangioma with a good outcome. A 57×38 mm heterogeneous hepatic mass, mostly hypoechogenic was observed post prenatal ultrasound, at 33 weeks’ gestation (WG) and 5 days. Color Doppler confirmed the vascular pattern of the mass. The image size stayed stable, with no associated complications, and a cesarean birth at 37 WG was performed for fetal protection. Subsequent postnatal follow-up showed spontaneous regression of the tumor. Antenatal diagnosis and management of fetal liver masses are discussed in this paper. This case supports the hypothesis that complications of giant fetal hepatic hemangioma are not related only to its size. Prognostic factors and guidelines for follow-up need to be determined.

Sign in / Sign up

Export Citation Format

Share Document