Regioselective alkylation reaction of purines under microwave Irradiation

AbstractDuring solventless alkylation of phenol with 4-hydroxy-2-butanone under microwave irradiation, paratoluenesulfonic acid (pTSA)-modified montmorillonite clays gave, regioselectively, 4-(4′-hydroxyphenyl)-2-butanone (raspberry ketone). The duration for this reaction under microwave irradiation is much shorter than that of the conventional method. A comparative study of the alkylation reaction over a montmorillonite clay sample treated with 0.5 M-pTSA (0.5 M-pTSA clay) with that of Al-exchanged montmorillonite (Al3+-Mont) and beta-zeolite (HB) was carried out. The results show that the reaction time to reach equilibrium and the product distribution pattern for the reaction over 0.5 M-pTSA clay were similar to those values for the HB. Micropores formed on the clay surface during the pTSA treatment were found to enhance the rate of formation of C-alkylation. Micropores appear to enable better access to the active sites during the course of reaction.

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Synthesis and characterization of nickel(II) complexes of di-N-alkylated 14-membered tetraaza macrocycles containing cyclohexane rings via regioselective alkylation reaction

Inorganica Chimica Acta ◽

10.1016/s0020-1693(98)00123-6 ◽

1998 ◽

Vol 279 (2) ◽

pp. 238-242 ◽

Cited By ~ 14

Author(s):

Shin-Geol Kang ◽

Mi-Seon Kim ◽

Dongmok Whang ◽

Kimoon Kim

Keyword(s):

Synthesis And Characterization ◽

Alkylation Reaction ◽

Regioselective Alkylation ◽

Tetraaza Macrocycles

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Regioselective alkylation reaction of the 2′-deoxyctidine with 9-aminomethyl derivatives of SN38

Journal of Molecular Structure ◽

10.1016/j.molstruc.2018.08.096 ◽

2019 ◽

Vol 1176 ◽

pp. 298-302 ◽

Cited By ~ 1

Author(s):

Beata Naumczuk ◽

Robert Kawęcki ◽

Wojciech Bocian ◽

Elżbieta Bednarek ◽

Jerzy Sitkowski ◽

...

Keyword(s):

Alkylation Reaction ◽

Regioselective Alkylation ◽

Aminomethyl Derivatives ◽

Derivatives Of

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Synthesis of 1, 1'-(1, 4- butanediyl)bis(imidazole) under microwave irradiation

10.3390/ecsoc-12-01261 ◽

2008 ◽

Author(s):

Azadeh Tadjarodi ◽

Sharareh Ilka

Keyword(s):

Microwave Irradiation

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Potential of microwave irradiation on the postharvest control of cowpea weevil and the proximate composition of cowpea seeds

10.1603/ice.2016.108832 ◽

2016 ◽

Author(s):

Christopher Ogbuji Echereobia

Keyword(s):

Microwave Irradiation ◽

Proximate Composition ◽

Cowpea Weevil ◽

Cowpea Seeds ◽

Postharvest Control

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Effect of Microwave Irradiation on Biological Objects

Telecommunications and Radio Engineering ◽

10.1615/telecomradeng.v57.i2-3.160 ◽

2002 ◽

Vol 57 (2-3) ◽

pp. 10

Author(s):

Yu. G. Shkorbatov

Keyword(s):

Microwave Irradiation ◽

Biological Objects

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Eco-Friendly Synthesis of Pyrazoline Derivatives

International Journal of Pharmaceutical and Clinical Research ◽

10.25258/ijpcr.v9i04.8538 ◽

2017 ◽

Vol 9 (04) ◽

Cited By ~ 1

Author(s):

Mahesh G. Kharatmol ◽

Deepali Jagdale

Keyword(s):

Ionic Liquids ◽

Microwave Irradiation ◽

Organic Synthesis ◽

Ultrasonic Irradiation ◽

Minimal Energy ◽

Anticancer Activities ◽

Conventional Methods

Pyrazoline class of compounds serve as better moieties for an array of treatments, they have antibacterial, antifungal, antiinflammatory, antipyretic, diuretic, cardiovascular activities. Apart from these they also have anticancer activities. So, pertaining to its importance, many attempts are made to synthesize pyrazolines. Since conventional methods of organic synthesis are energy and time consuming. There are elaborate pathways for green and eco-friendly synthesis of pyrazoline derivatives including microwave irradiation, ultrasonic irradiation, grinding and use of ionic liquids which assures the synthesis of the same within much lesser time and by use of minimal energy

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