Tetracyclic benzodiazepines. 4. Synthesis of the novel benzo[c]pyrrolo[1,2,3-ef][1,5]benzodiazepine ring system, and derivatives with potential antipsychotic activity

1987 ◽  
Vol 24 (6) ◽  
pp. 1599-1604 ◽  
Author(s):  
Edward J. Glamkowski ◽  
Yulin Chiang
Keyword(s):  
Ring System ◽  
The Novel ◽  
Antipsychotic Activity

scholarly journals Synthesis and Evaluation of the Tetracyclic Ring-System of Isocryptolepine and Regioiso-Mers for Antimalarial, Antiproliferative and Antimicrobial Activities

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3268
Author(s):  
Katja S. Håheim ◽  
Emil Lindbäck ◽  
Kah Ni Tan ◽  
Marte Albrigtsen ◽  
Ida T. Urdal Helgeland ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antimicrobial Activities ◽  
Ring System ◽  
Human Prostate ◽  
The Novel ◽  
Human Prostate Cancer ◽  
Biofilm Inhibition

A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the most promising antiplasmodial inhibition, with compound 10 displaying higher selectivity than the employed standards. The antiproliferative assay revealed novel pyridophenanthridine 4b to be significantly more active against human prostate cancer (IC50 = 24 nM) than Puromycin (IC50 = 270 nM) and Doxorubicin (IC50 = 830 nM), which are used for clinical treatment. Pyridocarbazoles 9 was also moderately effective against all the employed cancer cell lines and moreover showed excellent biofilm inhibition (9a: MBIC = 100 µM; 9b: MBIC = 100 µM).

Iminophosphorane-mediated synthesis of fused [1,2,4]triazines: preparation of the novel [1,2,4]triazino[4,3-b][1,2,4,5]tetrazine ring system

Tetrahedron ◽  
1988 ◽  
Vol 44 (8) ◽  
pp. 2249-2259 ◽  
Author(s):  
Pedro Molina ◽  
Mateo Alajarin ◽  
Angel Vidal ◽  
J. Elguero ◽  
R.M. Claramunt
Keyword(s):  
Ring System ◽  
The Novel

The squalestatins: Cleavage of the bicyclic core via the novel 2,8,9-trioxabicyclo[3.3.1]nonane ring system

1994 ◽  
Vol 35 (11) ◽  
pp. 1789-1792 ◽  
Author(s):  
Daniele Andreotti ◽  
Panayiotis A. Procopiou ◽  
Nigel S. Watson
Keyword(s):  
Ring System ◽  
The Novel

ChemInform Abstract: The Chemistry of Bis-spiroactals. Synthesis of the Novel 1,7,9-Trioxadispiro(5.1.5.3)hexadecane Ring System.

ChemInform ◽  
1990 ◽  
Vol 21 (19) ◽  
Author(s):  
M. A. BRIMBLE ◽  
C. J. RUSH ◽  
G. M. WILLIAMS ◽  
E. N. BAKER
Keyword(s):  
Ring System ◽  
The Novel

Concise Syntheses of the Novel 1H-Pyrrolo[3,2-g]quinazoline Ring System and its [2,3-f] Angular Isomer

1996 ◽  
Vol 61 (3) ◽  
pp. 1155-1158 ◽  
Author(s):  
H. D. Hollis Showalter ◽  
Li Sun ◽  
Anthony D. Sercel ◽  
R. Thomas Winters ◽  
William A. Denny ◽  
...  
Keyword(s):  
Ring System ◽  
The Novel
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