Prognostic role of nuclear factor/IB and bone remodeling proteins in metastatic giant cell tumor of bone: A retrospective study

Giant cell tumor of bone (GCT) is a bone tumor consisting of numerous multinucleated osteoclastic giant cells involved in bone resorption and neoplastic osteoblast-like stromal cells responsible for tumor growth. The tumor occasionally metastasizes to the lung; however, factors leading to metastasis in this tumor are unknown. The TWIST-1 protein (also referred to as TWIST) has been suggested to be involved in epithelial-mesenchymal transition (EMT) and tumor progression in some cancers. In this study we investigated the functional role of TWIST in GCT cell angiogenesis and migration. Overexpression of TWIST in neoplastic GCT stromal cells significantly increased mRNA and protein expression of VEGF and VEGFR1 in vitro, whereas knockdown of TWIST resulted in decreased VEGF and VEGFR1 expression. A stable cell line with TWIST overexpression resulted in features of EMT including increased cell migration and downregulation of E-cadherin. The results of our study indicate that TWIST may play an important role in angiogenesis and cell migration in GCT.

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Giant cell tumor of the plantar tendon sheath: Role of MR imaging in diagnosis case report

Clinical Imaging ◽

10.1016/0899-7071(93)90058-u ◽

1993 ◽

Vol 17 (2) ◽

pp. 153-155 ◽

Cited By ~ 7

Author(s):

Edward H. Demouy ◽

Kuniyuki Kaneko ◽

Howard M. Bear ◽

Raoul P. Rodriguez

Keyword(s):

Case Report ◽

Mr Imaging ◽

Giant Cell Tumor ◽

Giant Cell ◽

Tendon Sheath ◽

Cell Tumor

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Role of adjuvant radiation therapy in unusually rare primary malignant osteoclast-like giant cell tumor of the kidney

Indian Journal of Cancer ◽

10.4103/0019-509x.76638 ◽

2011 ◽

Vol 48 (1) ◽

pp. 123 ◽

Cited By ~ 1

Author(s):

MS Tiwana ◽

S Kakkar ◽

N Shirazi ◽

P Upadhya ◽

H Nautiyal

Keyword(s):

Radiation Therapy ◽

Giant Cell Tumor ◽

Giant Cell ◽

Cell Tumor ◽

Adjuvant Radiation ◽

Adjuvant Radiation Therapy

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Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone

Human Pathology ◽

10.1016/j.humpath.2010.03.001 ◽

2010 ◽

Vol 41 (9) ◽

pp. 1320-1329 ◽

Cited By ~ 19

Author(s):

Isabella W.Y. Mak ◽

Eric P. Seidlitz ◽

Robert W. Cowan ◽

Robert E. Turcotte ◽

Snezana Popovic ◽

...

Keyword(s):

Bone Resorption ◽

Matrix Metalloproteinase ◽

Giant Cell Tumor ◽

Giant Cell ◽

Cell Tumor ◽

Matrix Metalloproteinase 13

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Giant Cell Tumor: A Rare Condition in the Immature Skeleton—A Retrospective Study of Symptoms, Treatment, and Outcome in 16 Children

Sarcoma ◽

10.1155/2016/3079835 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Thale M. Asp Strøm ◽

Anette Torød Skeie ◽

Ingvild Koren Lobmaier ◽

Olga Zaikova

Keyword(s):

Retrospective Study ◽

Giant Cell Tumor ◽

Giant Cell ◽

Rare Condition ◽

Functional Results ◽

Cell Tumor ◽

Initial Symptom ◽

Recurrence Rates ◽

Intralesional Curettage ◽

Immature Skeleton

Background. Pediatric giant cell tumor (GCT) of bone is rare and the course of the disease in the immature skeleton is sparsely described. We performed a retrospective study addressing symptoms, treatment, and outcome in children with GCT.Methods. Review of medical records and images of patients with GCT. Patients were detected from our hospital prospective database and those with open epiphyseal cartilages were included.Results. 16 children (75% girls) from 6 to 15 years old were identified. Eight lesions (50%) were in long bones and 4 (25%) in flat bones. One lesion appeared to be purely epiphyseal. All patients had pain as the initial symptom. Local recurrence developed in 2 patients. 14 of 16 patients returned to normal activity with no sequelae. One patient developed anisomelia after surgery.Conclusions. The biological tumor behavior in children does not seem to differ from what is reported in adults. Lesions in flat bones are very unusual, but our data alone do not provide enough evidence to conclude that this is more common in the immature skeleton. Literature review showed only one previous case report describing a purely epiphyseal GCT. Intralesional curettage is appropriate treatment and gives good functional results with acceptable recurrence rates.

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The role of a magnet-resonance tomography in diagnosis of a teno-synovial giant-cell tumor (the pigment villo-nodular synoviitis) of a knee joint

Klinicheskaia khirurgiia ◽

10.26779/2522-1396.2019.11-12.63 ◽

2019 ◽

Vol 86 (11-12) ◽

pp. 63-68

Author(s):

Yu. O. Kostogryz ◽

O.A. Kostogryz

Keyword(s):

Knee Joint ◽

Giant Cell Tumor ◽

Giant Cell ◽

Gold Standard ◽

Treatment Algorithm ◽

Disease Recurrence ◽

Cell Tumor ◽

Standard Procedures ◽

Magnet Resonance

Objective. To study and analyze the modern possibilities and role of magnet-resonance tomography in diagnosis of teno-synovial giant-cell tumor (pigmented villo-nodular synoviitis) of a knee joint. To improve diagnosis and monitoring of the disease, using the estimation scale elaborated. Materials and methods. In the investigation 77 patients with pathohistologically verified teno-synovial giant-cell tumor (pigmented villo-nodular synoviitis) of a knee joint were included. The patients were distributed into two groups: the main - 52 patients, who were operated and examined, using diagnostic-treatment algorithm, proposed by the authors, and a control one - 25 patients, who were examined and treated in accordance to standard procedures. Results. Magnet-resonance tomography constitutes a «gold standard» in diagnosis of a pigment villo-nodular synovitis of a knee joint. There was established, that a distance between the graphic plots data, obtained in accordance to Ogilvie-Harris and Ogilvie-Harris-Kostogryz scales, which equals 2 and more, trusts the absence of the disease recurrence. A number «2» was selected not incidentally, because the estimate in 2 points in accordance to the scale equals a criterion «good», and in a 3 points - a criterion «excellent». Conclusion. Application of a function-prognosis scale of Ogilvie-Harris-Kostogryz is directly connected with magnet-resonance tomography. With the help of this scale it is possible to estimate the joint functional state, and, more than using the scale existing, to monitor the disease, as well as to mention about the operation radicalism and the risk of the recurrence occurrence.

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