scholarly journals Role of Bisphosphonates as Adjuvants of Surgery in Giant Cell Tumor of Spine

10.14444/5087 ◽  
2018 ◽  
Vol 12 (6) ◽  
pp. 695-702
Author(s):  
CHAITANYA DEV PANNU ◽  
PANKAJ KANDHWAL ◽  
VIJAY RAGHAVAN ◽  
SHAH ALAM KHAN ◽  
SHISHIR RASTOGI ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor

Role of radiologic imaging in management planning of giant cell tumor of bone

1984 ◽  
Vol 12 (2) ◽  
pp. 79-89 ◽  
Author(s):  
E. Levine ◽  
A. A. De Smet ◽  
J. R. Neff
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Management Planning ◽  
Radiologic Imaging

RECURRENCE OF GIANT CELL TUMOR OF BONE: THE ROLE OF MRI IN DIAGNOSIS

Orthopedics ◽  
1997 ◽  
Vol 20 (1) ◽  
pp. 67-69
Author(s):  
Barry J Waldman ◽  
Elias A Zerhouni ◽  
Frank J Frassica
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor

scholarly journals The Role of TWIST in Angiogenesis and Cell Migration in Giant Cell Tumor of Bone

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Shalini Singh ◽  
Isabella W. Y. Mak ◽  
Divya Handa ◽  
Michelle Ghert
Keyword(s):  
Cell Migration ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Stromal Cells ◽  
Epithelial Mesenchymal Transition ◽  
Cell Tumor ◽  
Stable Cell Line ◽  
Mesenchymal Transition

Giant cell tumor of bone (GCT) is a bone tumor consisting of numerous multinucleated osteoclastic giant cells involved in bone resorption and neoplastic osteoblast-like stromal cells responsible for tumor growth. The tumor occasionally metastasizes to the lung; however, factors leading to metastasis in this tumor are unknown. The TWIST-1 protein (also referred to as TWIST) has been suggested to be involved in epithelial-mesenchymal transition (EMT) and tumor progression in some cancers. In this study we investigated the functional role of TWIST in GCT cell angiogenesis and migration. Overexpression of TWIST in neoplastic GCT stromal cells significantly increased mRNA and protein expression of VEGF and VEGFR1 in vitro, whereas knockdown of TWIST resulted in decreased VEGF and VEGFR1 expression. A stable cell line with TWIST overexpression resulted in features of EMT including increased cell migration and downregulation of E-cadherin. The results of our study indicate that TWIST may play an important role in angiogenesis and cell migration in GCT.

Giant cell tumor of the plantar tendon sheath: Role of MR imaging in diagnosis case report

1993 ◽  
Vol 17 (2) ◽  
pp. 153-155 ◽  
Author(s):  
Edward H. Demouy ◽  
Kuniyuki Kaneko ◽  
Howard M. Bear ◽  
Raoul P. Rodriguez
Keyword(s):  
Case Report ◽  
Mr Imaging ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Cell Tumor

Role of adjuvant radiation therapy in unusually rare primary malignant osteoclast-like giant cell tumor of the kidney

2011 ◽  
Vol 48 (1) ◽  
pp. 123 ◽  
Author(s):  
MS Tiwana ◽  
S Kakkar ◽  
N Shirazi ◽  
P Upadhya ◽  
H Nautiyal
Keyword(s):  
Radiation Therapy ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Adjuvant Radiation ◽  
Adjuvant Radiation Therapy

Prognostic role of nuclear factor/IB and bone remodeling proteins in metastatic giant cell tumor of bone: A retrospective study

2015 ◽  
Vol 33 (8) ◽  
pp. 1205-1211 ◽  
Author(s):  
Irene Quattrini ◽  
Serena Pollino ◽  
Laura Pazzaglia ◽  
Amalia Conti ◽  
Chiara Novello ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Bone Remodeling ◽  
Cell Tumor ◽  
Nuclear Factor ◽  
Prognostic Role

Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone

2010 ◽  
Vol 41 (9) ◽  
pp. 1320-1329 ◽  
Author(s):  
Isabella W.Y. Mak ◽  
Eric P. Seidlitz ◽  
Robert W. Cowan ◽  
Robert E. Turcotte ◽  
Snezana Popovic ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Matrix Metalloproteinase ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Matrix Metalloproteinase 13

scholarly journals The role of a magnet-resonance tomography in diagnosis of a teno-synovial giant-cell tumor (the pigment villo-nodular synoviitis) of a knee joint

2019 ◽  
Vol 86 (11-12) ◽  
pp. 63-68
Author(s):  
Yu. O. Kostogryz ◽  
O.A. Kostogryz
Keyword(s):  
Knee Joint ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Gold Standard ◽  
Treatment Algorithm ◽  
Disease Recurrence ◽  
Cell Tumor ◽  
Standard Procedures ◽  
Magnet Resonance

Objective. To study and analyze the modern possibilities and role of magnet-resonance tomography in diagnosis of teno-synovial giant-cell tumor (pigmented villo-nodular synoviitis) of a knee joint. To improve diagnosis and monitoring of the disease, using the estimation scale elaborated. Materials and methods. In the investigation 77 patients with pathohistologically verified teno-synovial giant-cell tumor (pigmented villo-nodular synoviitis) of a knee joint were included. The patients were distributed into two groups: the main - 52 patients, who were operated and examined, using diagnostic-treatment algorithm, proposed by the authors, and a control one - 25 patients, who were examined and treated in accordance to standard procedures. Results. Magnet-resonance tomography constitutes a «gold standard» in diagnosis of a pigment villo-nodular synovitis of a knee joint. There was established, that a distance between the graphic plots data, obtained in accordance to Ogilvie-Harris and Ogilvie-Harris-Kostogryz scales, which equals 2 and more, trusts the absence of the disease recurrence. A number «2» was selected not incidentally, because the estimate in 2 points in accordance to the scale equals a criterion «good», and in a 3 points - a criterion «excellent». Conclusion. Application of a function-prognosis scale  of Ogilvie-Harris-Kostogryz is directly connected with magnet-resonance tomography. With the help of this scale it is possible to estimate the joint functional state, and, more than using the scale existing, to monitor the disease, as well as to mention about the operation radicalism and the risk of the recurrence occurrence.

scholarly journals Stromal Cell-Derived CCL20 Promotes Tumor Progression and Osteolysis in Giant Cell Tumor of Bone

2018 ◽  
Vol 51 (5) ◽  
pp. 2472-2483 ◽  
Author(s):  
Chenglong Zhao ◽  
Dongsheng Wang ◽  
Liang Tang ◽  
Zhichao Zhang ◽  
Song Li ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Mononuclear Cells ◽  
Bone Destruction ◽  
Cell Tumor ◽  
Migration Ability ◽  
And Migration ◽  
Proliferation And Migration

Background/Aims: Giant cell tumor of bone (GCTB), one of the most common primary bone tumors, leads to extensive bone destruction. However, the mechanisms underlying GCTB progression remain elusive and prognostic factors and treatment targets are required. In the current study, we explored the function of the chemokine family member CCL20 in GCTB progression. Methods: We explored the expression of CCL20 in stromal cells (GCTSCs) using microarray. Clinical analyses of the role of CCL20 in tumor progression were performed based on the patient cohort of our institution. The role of CCL20 in tumor proliferation was evaluated by MTS assay, migration ability was measured by a Transwell assay, and osteoclastogenesis was induced by CCL20 or GCTSC-conditioned medium. Quantitative PCR and western blot were used to measure the expression levels of mRNAs and proteins related to tumor progression. Results: CCL20 was upregulated in GCTSCs and correlated with tumor progression and prognosis. CCL20 induced GCTSC proliferation and migration in an autocrine manner. In addition, CCL20 recruited mononuclear cells and induced osteoclastogenesis by overactivating the AKT and NF-κB signaling pathways. Antibody blockade of CCL20 abolished the exacerbated osteoclastogenesis. Conclusion: Taken together, our data indicate that GCTSC secretion of CCL20 acts as a key modulator in the pathological progression of GCTB. It can promote GCTSC proliferation and migration in an autocrine manner and can recruit bone marrow monocytes to the tumor microenvironment and enhance osteoclastogenesis in a paracrine manner. These findings strongly indicate the potential prognostic and therapeutic value of CCL20 in GCTB.

The role of magnetic resonance imaging in giant cell tumor of bone

1987 ◽  
Vol 16 (8) ◽  
pp. 635-643 ◽  
Author(s):  
Steven D. Herman ◽  
Mamed Mesgarzadeh ◽  
Akbar Bonakdarpour ◽  
Murray K. Dalinka
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Resonance Imaging
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