scholarly journals Role of Bisphosphonates as Adjuvants of Surgery in Giant Cell Tumor of Spine

10.14444/5087 ◽  
2018 ◽  
Vol 12 (6) ◽  
pp. 695-702
Author(s):  
CHAITANYA DEV PANNU ◽  
PANKAJ KANDHWAL ◽  
VIJAY RAGHAVAN ◽  
SHAH ALAM KHAN ◽  
SHISHIR RASTOGI ◽  
...  
1984 ◽  
Vol 12 (2) ◽  
pp. 79-89 ◽  
Author(s):  
E. Levine ◽  
A. A. De Smet ◽  
J. R. Neff

Orthopedics ◽  
1997 ◽  
Vol 20 (1) ◽  
pp. 67-69
Author(s):  
Barry J Waldman ◽  
Elias A Zerhouni ◽  
Frank J Frassica

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Shalini Singh ◽  
Isabella W. Y. Mak ◽  
Divya Handa ◽  
Michelle Ghert

Giant cell tumor of bone (GCT) is a bone tumor consisting of numerous multinucleated osteoclastic giant cells involved in bone resorption and neoplastic osteoblast-like stromal cells responsible for tumor growth. The tumor occasionally metastasizes to the lung; however, factors leading to metastasis in this tumor are unknown. The TWIST-1 protein (also referred to as TWIST) has been suggested to be involved in epithelial-mesenchymal transition (EMT) and tumor progression in some cancers. In this study we investigated the functional role of TWIST in GCT cell angiogenesis and migration. Overexpression of TWIST in neoplastic GCT stromal cells significantly increased mRNA and protein expression of VEGF and VEGFR1 in vitro, whereas knockdown of TWIST resulted in decreased VEGF and VEGFR1 expression. A stable cell line with TWIST overexpression resulted in features of EMT including increased cell migration and downregulation of E-cadherin. The results of our study indicate that TWIST may play an important role in angiogenesis and cell migration in GCT.


1993 ◽  
Vol 17 (2) ◽  
pp. 153-155 ◽  
Author(s):  
Edward H. Demouy ◽  
Kuniyuki Kaneko ◽  
Howard M. Bear ◽  
Raoul P. Rodriguez

2015 ◽  
Vol 33 (8) ◽  
pp. 1205-1211 ◽  
Author(s):  
Irene Quattrini ◽  
Serena Pollino ◽  
Laura Pazzaglia ◽  
Amalia Conti ◽  
Chiara Novello ◽  
...  

2010 ◽  
Vol 41 (9) ◽  
pp. 1320-1329 ◽  
Author(s):  
Isabella W.Y. Mak ◽  
Eric P. Seidlitz ◽  
Robert W. Cowan ◽  
Robert E. Turcotte ◽  
Snezana Popovic ◽  
...  

2019 ◽  
Vol 86 (11-12) ◽  
pp. 63-68
Author(s):  
Yu. O. Kostogryz ◽  
O.A. Kostogryz

Objective. To study and analyze the modern possibilities and role of magnet-resonance tomography in diagnosis of teno-synovial giant-cell tumor (pigmented villo-nodular synoviitis) of a knee joint. To improve diagnosis and monitoring of the disease, using the estimation scale elaborated. Materials and methods. In the investigation 77 patients with pathohistologically verified teno-synovial giant-cell tumor (pigmented villo-nodular synoviitis) of a knee joint were included. The patients were distributed into two groups: the main - 52 patients, who were operated and examined, using diagnostic-treatment algorithm, proposed by the authors, and a control one - 25 patients, who were examined and treated in accordance to standard procedures. Results. Magnet-resonance tomography constitutes a «gold standard» in diagnosis of a pigment villo-nodular synovitis of a knee joint. There was established, that a distance between the graphic plots data, obtained in accordance to Ogilvie-Harris and Ogilvie-Harris-Kostogryz scales, which equals 2 and more, trusts the absence of the disease recurrence. A number «2» was selected not incidentally, because the estimate in 2 points in accordance to the scale equals a criterion «good», and in a 3 points - a criterion «excellent». Conclusion. Application of a function-prognosis scale  of Ogilvie-Harris-Kostogryz is directly connected with magnet-resonance tomography. With the help of this scale it is possible to estimate the joint functional state, and, more than using the scale existing, to monitor the disease, as well as to mention about the operation radicalism and the risk of the recurrence occurrence.


2018 ◽  
Vol 51 (5) ◽  
pp. 2472-2483 ◽  
Author(s):  
Chenglong Zhao ◽  
Dongsheng Wang ◽  
Liang Tang ◽  
Zhichao Zhang ◽  
Song Li ◽  
...  

Background/Aims: Giant cell tumor of bone (GCTB), one of the most common primary bone tumors, leads to extensive bone destruction. However, the mechanisms underlying GCTB progression remain elusive and prognostic factors and treatment targets are required. In the current study, we explored the function of the chemokine family member CCL20 in GCTB progression. Methods: We explored the expression of CCL20 in stromal cells (GCTSCs) using microarray. Clinical analyses of the role of CCL20 in tumor progression were performed based on the patient cohort of our institution. The role of CCL20 in tumor proliferation was evaluated by MTS assay, migration ability was measured by a Transwell assay, and osteoclastogenesis was induced by CCL20 or GCTSC-conditioned medium. Quantitative PCR and western blot were used to measure the expression levels of mRNAs and proteins related to tumor progression. Results: CCL20 was upregulated in GCTSCs and correlated with tumor progression and prognosis. CCL20 induced GCTSC proliferation and migration in an autocrine manner. In addition, CCL20 recruited mononuclear cells and induced osteoclastogenesis by overactivating the AKT and NF-κB signaling pathways. Antibody blockade of CCL20 abolished the exacerbated osteoclastogenesis. Conclusion: Taken together, our data indicate that GCTSC secretion of CCL20 acts as a key modulator in the pathological progression of GCTB. It can promote GCTSC proliferation and migration in an autocrine manner and can recruit bone marrow monocytes to the tumor microenvironment and enhance osteoclastogenesis in a paracrine manner. These findings strongly indicate the potential prognostic and therapeutic value of CCL20 in GCTB.


1987 ◽  
Vol 16 (8) ◽  
pp. 635-643 ◽  
Author(s):  
Steven D. Herman ◽  
Mamed Mesgarzadeh ◽  
Akbar Bonakdarpour ◽  
Murray K. Dalinka

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