Essential Fatty Acid Deficiency with SMOFlipid Reduction in an Infant with Intestinal Failure-Associated Liver Disease

2018 ◽  
Vol 43 (3) ◽  
pp. 438-441 ◽  
Author(s):  
Naureen Memon ◽  
Karen Hussein ◽  
Thomas Hegyi ◽  
Aimee Herdt ◽  
Ian J. Griffin
Keyword(s):  
Fatty Acid ◽  
Liver Disease ◽  
Essential Fatty Acid ◽  
Essential Fatty Acid Deficiency ◽  
Intestinal Failure ◽  
Acid Deficiency ◽  
Fatty Acid Deficiency

Intestinal absorption and postabsorptive metabolism of linoleic acid in rats with short-term bile duct ligation

2000 ◽  
Vol 279 (6) ◽  
pp. G1242-G1248 ◽  
Author(s):  
Deanna M. Minich ◽  
Rick Havinga ◽  
Frans Stellaard ◽  
Roel J. Vonk ◽  
Folkert Kuipers ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Liver Disease ◽  
Linoleic Acid ◽  
Bile Duct ◽  
Essential Fatty Acid ◽  
Essential Fatty Acid Deficiency ◽  
Cholestatic Liver Disease ◽  
Acid Deficiency ◽  
Fatty Acid Deficiency ◽  
Acid Administration

We investigated in bile duct-ligated (BDL) and sham-operated control rats whether the frequent presence of essential fatty acid deficiency in cholestatic liver disease could be related to linoleic acid malabsorption, altered linoleic acid metabolism, or both. In plasma of BDL rats, the triene-to-tetraene ratio, a biochemical marker for essential fatty acid deficiency, was increased compared with controls (0.024 ± 0.004 vs. 0.013 ± 0.001; P < 0.05). Net and percentage of dietary linoleic acid absorbed were decreased in BDL rats compared with control rats (1.50 ± 0.16 mmol/day and 81.3 ± 3.3% vs. 2.08 ± 0.07 mmol/day and 99.2 ± 0.1%, respectively; each P < 0.001). At 24 h after [13C]linoleic acid administration, BDL rats had a similar ratio of plasma [13C]arachidonic acid to plasma [13C]linoleic acid concentration compared with control rats. Δ6-Desaturase activity was not significantly different in hepatic microsomes from control or BDL rats. At 3 h after [13C]linoleic acid administration, plasma appearance of [13C]linoleic acid and cumulative expiration of 13CO2 were decreased in BDL rats, compared with controls (by 54% and 80%, respectively). The present data indicate that the impaired linoleic acid status in cholestatic liver disease is mainly due to decreased net absorption and not to quantitative alterations in postabsorptive metabolism.

Sites of Conditional Essential Fatty Acid Deficiency in End Stage Liver Disease

2001 ◽  
Vol 25 (4) ◽  
pp. 188-193 ◽  
Author(s):  
Peter A. Burke ◽  
Pei Ra. Ling ◽  
Robert A. Forse ◽  
David W. Lewis ◽  
Roger Jenkins ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Liver Disease ◽  
Essential Fatty Acid ◽  
Essential Fatty Acid Deficiency ◽  
End Stage Liver Disease ◽  
Acid Deficiency ◽  
Fatty Acid Deficiency ◽  
End Stage
Sign in / Sign up

Export Citation Format

Share Document