scholarly journals Adjunctive use of enamel matrix derivatives to porcine‐derived xenograft for the treatment of one‐wall intrabony defects: Two‐year longitudinal results of a randomized controlled clinical trial

2019 ◽  
Vol 91 (7) ◽  
pp. 880-889
Author(s):  
Jae‐Hong Lee ◽  
Do‐Hyung Kim ◽  
Seong‐Nyum Jeong
Keyword(s):  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Enamel Matrix ◽  
Randomized Controlled Clinical Trial ◽  
Intrabony Defects ◽  
Randomized Controlled ◽  
Enamel Matrix Derivatives ◽  
Matrix Derivatives

scholarly journals Healing of intrabony defects following regenerative surgery by means of single-flap approach in conjunction with either hyaluronic acid or an enamel matrix derivative: a 24-month randomized controlled clinical trial

2021 ◽  
Author(s):  
Andrea Pilloni ◽  
Mariana A. Rojas ◽  
Lorenzo Marini ◽  
Paola Russo ◽  
Yoshinori Shirakata ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Test Group ◽  
Enamel Matrix Derivative ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Enamel Matrix ◽  
Randomized Controlled Clinical Trial ◽  
Intrabony Defects ◽  
Randomized Controlled ◽  
Matrix Derivative

Abstract Objectives The aim of this randomized controlled clinical trial was to compare the clinical outcomes obtained in intrabony defects following regenerative periodontal surgery using the single-flap approach (SFA) in conjunction with either hyaluronic acid (HA) or enamel matrix derivative (EMD). Materials and methods Thirty-two intrabony defects in 32 healthy subjects were randomly assigned: HA (test group) or EMD (control group). Clinical attachment level (CAL), probing depth (PD), gingival recession (REC), and bleeding on probing (BOP) were recorded at baseline,12, 18, and 24 months after surgery. Results At 24 months, both treatments resulted in statistically significant clinical improvements evidenced by PD-reduction and CAL-gain (p<0.001). The mean CAL-gain was 2.19±1.11 mm in the test and 2.94±1.12 mm in the control sites (p=0.067). PD-reduction was statistically significantly higher for the control group (4.5±0.97 mm) than the test group (3.31±0.70 mm), (p=0.001). CAL-gain ≤ 3 mm was observed in 87.5% and in 62.5% of the test and control sites, respectively. Test sites showed slightly lower REC values than the control sites. No statistically significant differences were found for BOP between treatments. Conclusions The present findings indicate that both treatments led to statistically significant clinical improvements compared to baseline, although the application of EMD resulted in statistically significantly higher PD-reduction compared to the use of HA. Clinical relevance The use of HA in conjunction with a SFA resulted in significant PD-reduction and CAL-gain, pointing to the potential clinical relevance of this material in regenerative periodontal surgery.

Treatment of deep and shallow intrabony defects A multicenter randomized controlled clinical trial

1998 ◽  
Vol 25 (12) ◽  
pp. 981-987 ◽  
Author(s):  
Pierpaolo Cortellini ◽  
Gianfranco Carnevale ◽  
Mariano Sanz ◽  
Maurizio S. Tonetti
Keyword(s):  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Intrabony Defects ◽  
Randomized Controlled
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