scholarly journals The Effect of Additives on the Behavior of Phase Sensitive In Situ Forming Implants

2015 ◽  
Vol 104 (10) ◽  
pp. 3471-3480 ◽  
Author(s):  
Luis solorio ◽  
Divya Sundarapandiyan ◽  
Alex Olear ◽  
Agata A. Exner
Keyword(s):  
In Situ Forming ◽  
Effect Of Additives ◽  
Phase Sensitive ◽  
In Situ Forming Implants

In situ forming implants — an attractive formulation principle for parenteral depot formulations

2012 ◽  
Vol 161 (2) ◽  
pp. 668-679 ◽  
Author(s):  
Sabine Kempe ◽  
Karsten Mäder
Keyword(s):  
In Situ Forming ◽  
In Situ Forming Implants

First report on the efficacy of l-alanine-based in situ-forming implants for the long-term parenteral delivery of drugs

2005 ◽  
Vol 108 (2-3) ◽  
pp. 433-441 ◽  
Author(s):  
François Plourde ◽  
Aude Motulsky ◽  
Anne-Claude Couffin-Hoarau ◽  
Didier Hoarau ◽  
Huy Ong ◽  
...  
Keyword(s):  
First Report ◽  
Parenteral Delivery ◽  
In Situ Forming ◽  
In Situ Forming Implants

Isosorbide-based polysebacates as polymeric components for development of in situ forming implants

2019 ◽  
Vol 30 (4) ◽  
pp. 1072-1082
Author(s):  
Monika Śmiga-Matuszowicz ◽  
Anna Korytkowska-Wałach ◽  
Bożena Nowak
Keyword(s):  
In Situ Forming ◽  
In Situ Forming Implants

scholarly journals One-week in vivo sustained release of a peptide formulated into in situ forming implants

2017 ◽  
Vol 521 (1-2) ◽  
pp. 357-360 ◽  
Author(s):  
Marianne Parent ◽  
Igor Clarot ◽  
Sébastien Gibot ◽  
Marc Derive ◽  
Philippe Maincent ◽  
...  
Keyword(s):  
Sustained Release ◽  
In Situ Forming ◽  
In Situ Forming Implants

In-situ forming implants for the treatment of periodontal diseases: Simultaneous controlled release of an antiseptic and an anti-inflammatory drug

2019 ◽  
Vol 572 ◽  
pp. 118833 ◽  
Author(s):  
M. Lizambard ◽  
T. Menu ◽  
M. Fossart ◽  
C. Bassand ◽  
K. Agossa ◽  
...  
Keyword(s):  
Controlled Release ◽  
Periodontal Diseases ◽  
Inflammatory Drug ◽  
In Situ Forming ◽  
Anti Inflammatory ◽  
In Situ Forming Implants

scholarly journals Macroporous acrylamide phantoms improve prediction of in vivo performance of in situ forming implants

2016 ◽  
Vol 243 ◽  
pp. 225-231 ◽  
Author(s):  
Christopher Hernandez ◽  
Natalia Gawlik ◽  
Monika Goss ◽  
Haoyan Zhou ◽  
Selva Jeganathan ◽  
...  
Keyword(s):  
In Situ Forming ◽  
In Situ Forming Implants

scholarly journals Effect of Polymer Permeability and Solvent Removal Rate on In Situ Forming Implants: Drug Burst Release and Microstructure

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 520 ◽  
Author(s):  
Xiaowei Zhang ◽  
Liqun Yang ◽  
Chong Zhang ◽  
Danhua Liu ◽  
Shu Meng ◽  
...  
Keyword(s):  
Drug Release ◽  
Organic Solvent ◽  
Removal Rate ◽  
Solubility Parameters ◽  
Burst Release ◽  
Trimethylene Carbonate ◽  
Solvent Removal ◽  
In Situ Forming ◽  
In Situ Forming Implants

To explore the mechanism of drug release and depot formation of in situ forming implants (ISFIs), osthole-loaded ISFIs were prepared by dissolving polylactide, poly(lactide-co-glycolide), polycaprolactone, or poly(trimethylene carbonate) in different organic solvents, including N-methyl-2-pyrrolidone (NMP), dimethyl sulfoxide (DMSO), and triacetin (TA). Drug release, polymer degradation, solvent removal rate and depot microstructure were examined. The burst release effect could be reduced by using solvents exhibit slow forming phase inversion and less permeable polymers. Both the drug burst release and polymer depot microstructure were closely related to the removal rate of organic solvent. Polymers with higher permeability often displayed faster drug and solvent diffusion rates. Due to high polymer-solvent affinity, some of the organic solvent remained in the depot even after the implant was completely formed. The residual of organic solvent could be predicted by solubility parameters. The ISFI showed a lower initial release in vivo than that in vitro. In summary, the effects of different polymers and solvents on drug release and depot formation in ISFI systems were extensively investigated and discussed in this article. The two main factors, polymer permeability and solvent removal rate, were involved in different stages of drug release and depot formation in ISFI systems.

scholarly journals In-situ forming implants loaded with chlorhexidine and ibuprofen for periodontal treatment: Proof of concept study in vivo

2019 ◽  
Vol 569 ◽  
pp. 118564 ◽  
Author(s):  
Fareeha Batool ◽  
Kevimy Agossa ◽  
Martin Lizambard ◽  
Catherine Petit ◽  
Isaac Maximiliano Bugueno ◽  
...  
Keyword(s):  
Periodontal Treatment ◽  
Proof Of Concept ◽  
Concept Study ◽  
In Situ Forming ◽  
In Situ Forming Implants

scholarly journals Improving Treatment Efficacy of In Situ Forming Implants via Concurrent Delivery of Chemotherapeutic and Chemosensitizer

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Selva Jeganathan ◽  
Emily Budziszewski ◽  
Christopher Hernandez ◽  
Anshul Dhingra ◽  
Agata A. Exner
Keyword(s):  
Treatment Efficacy ◽  
In Situ Forming ◽  
In Situ Forming Implants
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